Jesper M. Mathiesen

Jesper M. Mathiesen

Associate Professor


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  1. Published

    1,2,3-triazolyl amino acids as AMPA receptor ligands

    Stanley, N. J., Pedersen, D. S., Nielsen, Birgitte, Kvist, T., Mathiesen, Jesper M., Bräuner, Hans, Taylor, D. K. & Abell, A. D., 15 Dec 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 24, p. 7512-7515

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists

    Ulven, Trond, Little, P. B., Receveur, J., Frimurer, Thomas Michael, Rist, Ø., Nørregaard, P. K., Mathiesen, Jesper M. & Högberg, T., 2006, In: Bioorganic & Medicinal Chemistry Letters. 16, 4, p. 1070-1075 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    A cAMP Biosensor-Based High-Throughput Screening Assay for Identification of Gs-Coupled GPCR Ligands and Phosphodiesterase Inhibitors

    Vedel, L., Bräuner, Hans & Mathiesen, Jesper M., 2015, In: Journal of Biomolecular Screening. 20, p. 849-857 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity

    Stanley, N. J., Hutchinson, M. R., Kvist, T., Nielsen, Birgitte, Mathiesen, Jesper M., Bräuner, Hans, Avery, T. D., Tiekink, E. R. T., Pedersen, D. S., Irvine, R. J., Abell, A. D. & Taylor, D. K., 2010, In: Bioorganic & Medicinal Chemistry. 18, 16, p. 6089-6098

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor

    He, F., Wu, C. G., Gao, Y., Rahman, Sabrina Nalini, Zaoralová, M., Papasergi-Scott, M. M., Gu, T. J., Robertson, M. J., Seven, A. B., Li, L., Mathiesen, Jesper M. & Skiniotis, G., 2024, In: Nature. 626, p. 1141–1148

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Allosteric modulators of group III metabotropic glutamate receptors as novel therapeutics

    Mathiesen, Jesper M. & Teresa Ramirez, M., 19 Apr 2016, Allosteric Receptor Modulation in Drug Targeting. CRC Press, p. 207-234 28 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  7. Published

    Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

    Uller, L., Mathiesen, Jesper M., Alenmyr, L., Korsgren, M., Ulven, Trond, Högberg, T., Andersson, G., Persson, C. G. A. & Kostenis, E., 1 Feb 2007, In: Respiratory Research. 8, 16

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Asymmetric activation of the calcium-sensing receptor homodimer

    Gao, Y., Robertson, M. J., Rahman, Sabrina Nalini, Seven, A. B., Zhang, C., Meyerowitz, J. G., Panova, O., Hannan, F. M., Thakker, R. V., Bräuner, Hans, Mathiesen, Jesper M. & Skiniotis, G., 2021, In: Nature. 595, p. 455-459

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene

    Molck, C., Harpsøe, Kasper, Gloriam, David E., Kaae, B. H., Jimenez, H. N., Uberti, M. A., Topiol, S., Clausen, Rasmus Prætorius, Madsen, Ulf, Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, Sep 2011, In: Current Neuropharmacology. 9, p. 43-43

    Research output: Contribution to journal › Conference abstract in journal › Research

  10. Published

    Crystal structure of the β2 adrenergic receptor-Gs protein complex

    Rasmussen, Søren Gøgsig Faarup, DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., Mathiesen, Jesper M., Shah, S. T. A., Lyons, J. A., Caffrey, M., Gellman, S. H., Steyaert, J., Skiniotis, G., Weis, W. I., Sunahara, R. K. & Kobilka, B. K., 29 Sep 2011, In: Nature. 477, 7366, p. 549-55 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Crystal structure of the μ-opioid receptor bound to a morphinan antagonist

    Manglik, A., Kruse, A. C., Kobilka, T. S., Thian, F. S., Mathiesen, Jesper M., Sunahara, R. K., Pardo, L., Weis, W. I., Kobilka, B. K. & Granier, S., 17 May 2012, In: Nature. 485, 7398, p. 321-326 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs

    Boesgaard, M. W., Harpsøe, Kasper, Malmberg, M., Underwood, C. R., Inoue, A., Mathiesen, Jesper M., König, G. M., Kostenis, E., Gloriam, David E. & Bräuner, Hans, 2020, In: Journal of Biological Chemistry. 295, 40, p. 13850-13861

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Delineation of the GPR15 receptor-mediated Gα protein signalling profile in recombinant mammalian cells

    Deng, Y., Moo, Ee Von, Almería, C. V. P., Gentry, P. R., Vedel, L., Mathiesen, Jesper M. & Bräuner, Hans, 2022, In: Basic and Clinical Pharmacology and Toxicology. 131, 2, p. 104-113

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

    Møller, T. C., Pedersen, M. F., van Senten, Jeffrey Roy, Seiersen, S. D., Mathiesen, Jesper M., Bouvier, M. & Bräuner, Hans, 2020, In: Scientific Reports. 10, 1, 13 p., 17395.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists

    Grimstrup, M., Receveur, J. M., Rist, Ø., Frimurer, Thomas Michael, Nielsen, P. A., Mathiesen, Jesper M. & Högberg, T., 1 Mar 2010, In: Bioorganic and Medicinal Chemistry Letters. 20, 5, p. 1638-1641 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    G-protein activation by a metabotropic glutamate receptor

    Seven, A. B., Barros-Álvarez, X., de Lapeyrière, M., Papasergi-Scott, M. M., Robertson, M. J., Zhang, C., Nwokonko, R. M., Gao, Y., Meyerowitz, J. G., Rocher, J. P., Schelshorn, D., Kobilka, B. K., Mathiesen, Jesper M. & Skiniotis, G., 2021, In: Nature. 595, p. 450-454

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Gs protein peptidomimetics as allosteric modulators of the β2-adrenergic receptor

    Boyhus, L. E., Danielsen, Mia, Bengtson, N. S., Kunze, M. B. A., Kubiak, X., Sminia, T. J., Løper, J. H., Tran, P. T., Lindorff-Larsen, Kresten, Rasmussen, Søren Gøgsig Faarup, Mathiesen, Jesper M. & Pedersen, D. S., 2018, In: RSC Advances. 8, 4, p. 2219-2228 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Glycine: a long-sought novel ligand for GPR158

    Rosenkilde, Mette & Mathiesen, Jesper M., 2023, In: Trends in Pharmacological Sciences. 44, 8, p. 489-491

    Research output: Contribution to journal › Letter › Research › peer-review

  19. Published

    Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2

    Mathiesen, Jesper M., Ulven, Trond, Martin, L., Gerlach, L., Heinemann, A. & Kostenis, E., 2005, In: Molecular Pharmacology. 68, 2, p. 393-402 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators

    Ritzén, A., Mathiesen, Jesper M. & Thomsen, C., 1 Oct 2005, In: Basic and Clinical Pharmacology and Toxicology. 97, 4, p. 202-213 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits

    Ulven, Trond, Receveur, J., Grimstrup, M., Rist, Ø., Frimurer, Thomas Michael, Gerlach, L., Mathiesen, Jesper M., Kostenis, E., Uller, L. & Högberg, T., 2006, In: Journal of Medicinal Chemistry. 49, 23, p. 6638-6641 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2

    Grimstrup, M., Rist, Ø., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Mathiesen, Jesper M., Kostenis, E. & Högberg, T., 1 Feb 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1181-1185 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    On the mechanism of interaction of potent, surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

    Mathiesen, Jesper M., Christopoulos, A., Ulven, Trond, Royer, J. F., Campillo, M., Heinemann, A., Pardo, L. & Kostenis, E., 2006, In: Molecular Pharmacology. 69, 4, p. 1441-1453 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators

    Mølck, C., Harpsøe, Kasper, Gloriam, David E., Clausen, Rasmus Prætorius, Madsen, Ulf, Pedersen, L., Jimenez, H. N., Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, 2012, In: Molecular Pharmacology. 82, 5, p. 929-37 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

    Mathiesen, Jesper M., Svendsen, N., Bräuner, Hans, Thomsen, C. & Ramirez, M. T., Mar 2003, In: British Journal of Pharmacology. 138, 6, p. 1026-30

    Research output: Contribution to journal › Journal article › Research › peer-review

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