Hans Bräuner
Prodekan for forskning
Faculty Service
Blegdamsvej 3
2200 København N.
- 2007
- Published
Synthesis of conformationally constrained glutamic acid homologues and investigation of their pharmacological profiles
Conti, P., Pinto, A., Tamborini, L., Grazioso, G., De Sarro, G., Bräuner, Hans, Szabo, G., Hársing, L. G. & De Micheli, C., 2007, In: ChemMedChem. 2, 11, p. 1639-1647 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The rat GPRC6A: cloning and characterization
Wellendorph, Petrine, Burhenne, N., Christiansen, B., Walter, B., Schmale, H. & Bräuner, Hans, 15 Jul 2007, In: Gene. 396, 2, p. 257-267 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
3B but which 3B? And that's just one of the questions: the heterogeneity of human 5-HT3 receptors
Jensen, Anders A., Davies, P. A., Bräuner, Hans & Krzywkowski, K., 2008, In: TIPS - Trends in Pharmacological Sciences. 29, 9, p. 437-444Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of GPRC6A: a 7TM receptor activated by L-alpha-amino acids and positively modulated by divalent cations
Wellendorph, Petrine, Hansen, K. B., Christiansen, B., Burhenne, N., Balsgaard, A., Greenwood, J. R., Walter, B., Schmale, H., Egebjerg, J. & Bräuner, Hans, 2008, In: Fundamental and Clinical Pharmacology. Suppl. 2, p. 19Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling
Krzywkowski, K. M., Davies, P. A., Irving, A. J., Bräuner, Hans & Jensen, Anders A., 2008, In: Pharmacogenetics and Genomics (Print Edition). 18, 12, p. 1027-1040Research output: Contribution to journal › Journal article › Research › peer-review
- Published
En genetisk variation i en serotonin–receptor – et muligt link til depression?
Krzywkowski, K. M., Feinberg-Zadek, P., Davies, P. A., Jensen, Anders A. & Bräuner, Hans, 2008, In: Dansk Kemi 83. 89, 6/7Research output: Contribution to journal › Journal article › Communication
- Published
High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor
Krzywkowski, K. M., Davies, P. A., Feinberg-Zadek, P. L., Bräuner, Hans & Jensen, Anders A., 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 2, p. 722-727Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands
Clausen, Rasmus Prætorius, Christensen, C., Hansen, K. B., Greenwood, J. R., Jørgensen, L., Micale, N., Madsen, J. C., Nielsen, Birgitte, Egebjerg, J., Bräuner, Hans, Traynelis, S. F. & Kristensen, Jesper Langgaard, 2008, In: Journal of Medicinal Chemistry. 51, 14, p. 4179-87Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel high-affinity and selective biaromatic 4-substituted ¿-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies
Høg, S., Wellendorph, Petrine, Nielsen, Birgitte, Frydenvang, Karla Andrea, Dahl, I. F., Bräuner, Hans, Brehm, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2008, In: Journal of Medicinal Chemistry. 51, 24, p. 8088-8095Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ny human GABA-transportør: et muligt mål for behandling af epilepsi
Christiansen, B., Kvist, T., Jensen, Anders A. & Bräuner, Hans, 2008, In: Lægemiddelforskning. p. 25-27Research output: Contribution to journal › Journal article › Communication
- Published
Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements
Hansen, K. B., Bräuner, Hans & Egebjerg, J., 2008, In: Combinatorial Chemistry & High Throughput Screening. 11, 4, p. 304-315Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of GABAB receptors by extracellular proteins and phosphorylation
Tiao, J. Y., Bradaia, A., Jensen, A. A., Biermann, B., Bräuner, Hans, Müller, M., Kaupmann, K., Gassmann, M. & Bettler, B., 2008, In: Neuropharmacology. 4, p. 626Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid
Pinto, A., Conti, P., De Amici, M., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte, Christesen, T., Bräuner, Hans & De Micheli, C., 2008, In: Journal of Medicinal Chemistry. 51, 7, p. 2311-2315Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The human GABA transporter GAT-2: From cloning to high throughput screening
Christiansen, B., Kvist, T., Jensen, Anders A. & Bräuner, Hans, 2008, Innovative drug development for headache disorders. Olesen, J. & Ramadan, N. (eds.). Oxford, Storbritannien: Oxford University Press, Vol. 16. p. 3-15 (Frontiers in headache research series, Vol. 16).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
The human γ-aminobutyric acid transporter GAT-2: from cloning to high throughput screening
Christiansen, B., Kvist, T., Jensen, Anders A. & Bräuner, Hans, 2008, Innovative Drug Development for Headache Disorders. Frontiers in Headache Research. Olesen, J. & Ramadan, N. (eds.). Oxford, UK: Oxford University Press, Vol. 16. p. 3-15Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2009
- Published
(R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action
Lehmann, A., Antonsson, M., Holmberg, A. A., Blackshaw, L. A., Brändén, L., Bräuner, Hans, Christiansen, B., Dent, J., Elebring, T., Jacobson, B., Jensen, J., Mattsson, J. P., Nilsson, K., Oja, S. S., Page, A. J., Saransaari, P. & von Unge, S., 2009, In: Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 504-512Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FLIPR assays of intracellular calcium in GPCR drug discovery
Hansen, K. B. & Bräuner, Hans, 2009, G protein-coupled receptors in drug discovery. Leifert, W. R. (ed.). United States: Humana Press, Vol. 552. p. 269-278 (Methods in Molecular Biology, Vol. 552).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Molecular basis for amino acid sensing by family C G-protein-coupled receptors
Wellendorph, Petrine & Bräuner, Hans, 2009, In: British Journal of Pharmacology. 156, 6, p. 869-884Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor
Faure, H., Gorojankina, T., Rice, N., Dauban, P., Dodd, R. H., Bräuner, Hans, Rognan, D. & Ruat, M., 2009, In: Cell Calcium. 46, 5-6, p. 323-332Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients
Wellendorph, Petrine, Johansen, L. D. & Bräuner, Hans, 2009, In: Molecular Pharmacology. 76, 3, p. 453-465Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions
Wellendorph, Petrine, Johansen, L. D., Jensen, Anders A., Casanova, E., Gassmann, M., Deprez, P., Clément-Lacroix, P., Bettler, B. & Bräuner, Hans, 2009, In: Journal of Molecular Endocrinology. 42, 3, p. 215-223Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain
Wellendorph, Petrine, Høg, S., Skonberg, C. & Bräuner, Hans, 2009, In: Fundamental and Clinical Pharmacology. 23, 2, p. 207-213 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Receptorer i historisk og nutidig belysning
Bräuner, Hans, 2009, In: Carlsbergfondet. Aarsskrift. p. 30-35Research output: Contribution to journal › Journal article › Communication
- Published
The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses
Guetg, N., Seddik, R., Vigot, R., Turecek, R., Gassmann, M., Vogt, K. E., Bräuner, Hans, Shigemoto, R., Kretz, O., Frotscher, M., Kulik, Á. & Bettler, B., 2009, In: Journal of Neuroscience. 29, 5, p. 1414-1423Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The four human ¿-aminobutyric acid (GABA) transporters: pharmacological characterization and validation of a highly efficient screening assay
Kvist, T., Christiansen, B., Jensen, Anders A. & Bräuner, Hans, 2009, In: Combinatorial Chemistry & High Throughput Screening. 12, 3, p. 241-249Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization
Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Xenopus oocyte electrophysiology in GPCR drug discovery
Hansen, K. B. & Bräuner, Hans, 2009, G protein-coupled receptors in drug discovery. Leifert, W. R. (ed.). United States: Humana Press, Vol. 552. p. 343-357 (Methods in Molecular Biology, Vol. 552).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- 2010
- Published
A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity
Stanley, N. J., Hutchinson, M. R., Kvist, T., Nielsen, Birgitte, Mathiesen, Jesper M., Bräuner, Hans, Avery, T. D., Tiekink, E. R. T., Pedersen, D. S., Irvine, R. J., Abell, A. D. & Taylor, D. K., 2010, In: Bioorganic & Medicinal Chemistry. 18, 16, p. 6089-6098Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites
Sabbatini, P., Wellendorph, Petrine, Høg, S., Pedersen, M. H. F., Bräuner, Hans, Martiny, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2010, In: Journal of Medicinal Chemistry. 53, 17, p. 6506-6510Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Homology modelling of the GABA transporter and analysis of tiagabine binding
Skovstrup, S., Taboureau, O., Bräuner, Hans & Jørgensen, Flemming Steen, 2010, In: ChemMedChem. 5, 7, p. 986-1000Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists
Hansen, K. B., Mullasseril, P., Dawit, S., Kurtkaya, N. L., Yuan, H., Vance, K. M., Orr, A. G., Kvist, T., Ogden, K. K., Le, P., Vellano, K. M., Lewis, I., Kurtkaya, S., Du, Y., Qui, M., Murphy, T. J., Snyder, J. P., Bräuner, Hans & Traynelis, S. F., 2010, In: Journal of Pharmacology and Experimental Therapeutics. 333, 3, p. 650-662Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: Design, synthesis, and pharmacological characterization
Conti, P., Pinto, A., Tamborini, L., Madsen, Ulf, Nielsen, Birgitte, Bräuner, Hans, Hansen, K. B., Landucci, E., Pellegrini-Giampietro, D. E., De Sarro, G., Donato Di Paola, E. & De Micheli, C., 2010, In: ChemMedChem. 5, 9, p. 1465-1475Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel radioiodinated γ-hydroxybutyric acid analogues for radiolabeling and photolinking of high-affinity γ-hydroxybutyric acid binding sites
Wellendorph, Petrine, Høg, S., Sabbatini, P., Pedersen, M. H. F., Martiny, L., Knudsen, Gitte Moos, Frølund, Bente, Clausen, Rasmus Prætorius & Bräuner, Hans, 2010, In: Journal of Pharmacology and Experimental Therapeutics. 335, 2, p. 458-464Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists
Mosley, C. A., Acker, T. M., Hansen, K. B., Mullasseril, P., Andersen, K. T., Le, P., Vellano, K. M., Bräuner, Hans, Liotta, D. C. & Traynelis, S. F., 2010, In: Journal of Medicinal Chemistry. 53, 15, p. 5476-5490Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Receptors: Structure, function, and pharmacology
Bräuner, Hans, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 189-205Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
- Published
The emerging role of promiscuous 7TM receptors as chemosensors for food intake
Wellendorph, Petrine, Johansen, L. D. & Bräuner, Hans, 1 Jan 2010, Incretins and insulin secretion. Litwack, G. (ed.). Amsterdam: Elsevier Editora, Vol. 84. p. 151-184 (Vitamins & hormones, Vol. 84).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Kemogenomik: receptoren set fra lægemiddelstoffets synspunkt
Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Pedersen, D. S. & Bräuner, Hans, Dec 2010, In: Lægemiddelforskning. 2010, p. 28-30Research output: Contribution to journal › Journal article › Communication
- Published
Biologiens låsesmed
Bräuner, Hans, 2 Dec 2010, In: Universitetsavisen. 2010, 9, p. 22-23Research output: Contribution to journal › Journal article › Communication
- Published
1,2,3-triazolyl amino acids as AMPA receptor ligands
Stanley, N. J., Pedersen, D. S., Nielsen, Birgitte, Kvist, T., Mathiesen, Jesper M., Bräuner, Hans, Taylor, D. K. & Abell, A. D., 15 Dec 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 24, p. 7512-7515Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Kemogenomik: Receptoren set fra lægemiddelstoffets synspunkt
Johansson, H., Jørgensen, T. B., Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Pedersen, D. S. & Bräuner, Hans, 2011, In: Dansk Kemi. 92, 11, p. 22-26Research output: Contribution to journal › Journal article › Research
- Published
The use of Xenopus oocytes in drug screening
Kvist, T., Hansen, K. B. & Bräuner, Hans, 2011, In: Expert Opinion on Drug Discovery. 6, 2, p. 141-153Research output: Contribution to journal › Review › Research › peer-review
- Published
Transmembrane a-helix 2 and 7 are important for small molecule-mediated activation of the GLP-1 receptor
Underwood, C. R., Knudsen, S. M., Wulff, B. S., Bräuner, Hans, Lau, J., Knudsen, L. B., Peters, G. H. J. & Reedtz-Runge, S., 2011, In: Pharmacology. 88, 5-6, p. 340-348 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Binding Mode of a Novel MPEP-Derived Metabotropic Glutamate Receptor Subtype 5 (mGluR5) NAM, 1,3-Bis(pyridin-2-ylethynyl)Benzene
Molck, C., Harpsøe, Kasper, Gloriam, David E., Kaae, B. H., Jimenez, H. N., Uberti, M. A., Topiol, S., Clausen, Rasmus Prætorius, Madsen, Ulf, Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, Sep 2011, In: Current Neuropharmacology. 9, p. 43-43Research output: Contribution to journal › Conference abstract in journal › Research
- Published
A highly selective agonist for the metabotropic glutamate receptor mGluR2
Nielsen, S. D., Fulco, M., Serpi, M., Nielsen, Birgitte, Hansen, M. B., Hansen, K. L., Thomsen, C., Brodbeck, R., Bräuner, Hans, Pellicciari, R., Norrby, P., Greenwood, J. R. & Clausen, Rasmus Prætorius, 23 Sep 2011, In: MedChemComm. 2, 11, p. 1120-1124Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor
Gloriam, David E., Wellendorph, Petrine, Johansen, L. D., Thomsen, A. R. B., Phonekeo, K., Pedersen, D. S. & Bräuner, Hans, 23 Nov 2011, In: Chemistry & Biology. 18, 11, p. 1489-1498Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
Rossol, M., Pierer, M., Raulien, N., Quandt, D., Meusch, U., Rothe, K., Schubert, K., Schöneberg, T., Schaefer, M., Krügel, U., Smajilovic, S., Bräuner, Hans, Baerwald, C. & Wagner, U., 2012, In: Nature Communications. 3, p. 1329Research output: Contribution to journal › Journal article › Research › peer-review
- Published
L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances
Clemmensen, Christoffer, Madsen, A. N., Smajilovic, S., Holst, Birgitte & Bräuner, Hans, 2012, In: Amino Acids. 43, 3, p. 1265-1275Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators
Mølck, C., Harpsøe, Kasper, Gloriam, David E., Clausen, Rasmus Prætorius, Madsen, Ulf, Pedersen, L., Jimenez, H. N., Nielsen, S. M., Mathiesen, Jesper M. & Bräuner, Hans, 2012, In: Molecular Pharmacology. 82, 5, p. 929-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-activity relationships for negative allosteric mGluR5 modulators
Kaae, B. H., Harpsøe, Kasper, Kvist, T., Mathiesen, Jesper M., Mølck, C., Gloriam, David E., Jimenez, H. N., Uberti, M. A., Nielsen, S. M., Nielsen, Birgitte, Bräuner, Hans, Sauerberg, P., Clausen, Rasmus Prætorius & Madsen, Ulf, 2012, In: ChemMedChem. 7, 3, p. 440-451Research output: Contribution to journal › Journal article › Research › peer-review
- Published
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent gamma-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction
Pan, Y., Gerasimov, M. R., Kvist, T., Wellendorph, Petrine, Madsen, K. K., Pera, E., Lee, H., Schousboe, Arne, Chebib, M., Bräuner, Hans, Craft, C. M., Brodie, J. D., Schiffer, W. K., Dewey, S. L., Miller, S. R. & Silverman, R. B., 1 Jan 2012, In: Journal of Medicinal Chemistry. 55, 1, p. 357-366Research output: Contribution to journal › Journal article › Research › peer-review
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Kemogenomik: Receptoren set fra lægemiddelstoffets synspunkt
Research output: Contribution to journal › Journal article › Research
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