Thomas Elbenhardt Jensen
Associate Professor
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The role of NADPH oxidase 2 in regulating IL-15 and PGC-1α gene expressions following a period of high intensity interval training: [The original title and the article is written in Persian!]
Baghersad Renani, L., Ravasi, A. A., Shabkhiz, F. & Jensen, Thomas Elbenhardt, 2019, In: Iranian Journal of Endocrinology and Metabolism. 20, 5, p. 263-272 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function
Blazev, R., Carl, C. S., Ng, Y-K., Molendijk, J., Voldstedlund, C. T., Zhao, Y., Xiao, D., Kueh, A. J., Miotto, P. M., Haynes, V. R., Hardee, J. P., Chung, J. D., McNamara, J. W., Qian, H., Gregorevic, P., Oakhill, J. S., Herold, M. J., Jensen, T. E., Lisowski, L., Lynch, G. S. & 6 others, , 2022, In: Cell Metabolism. 34, 10, p. 1561-1577.e9 27 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Skeletal muscle-specific activation of Gq signaling maintains glucose homeostasis
Bone, D. B. J., Meister, J., Knudsen, Jonas Roland, Dattaroy, D., Cohen, A., Lee, R., Lu, H., Metzger, D., Jensen, Thomas Elbenhardt & Wess, J., 2019, In: Diabetes. 68, 6, p. 1341-1352 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle
Bultot, L., Jensen, Thomas Elbenhardt, Lai, Y., Madsen, A. L. B., Collodet, C., Kviklyte, S., Deak, M., Yavari, A., Foretz, M., Ghaffari, S., Bellahcene, M., Ashrafian, H., Rider, M. H., Richter, Erik A. & Sakamoto, Kei, 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 4, p. E706-E719 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lactate administration activates the ERK1/2, mTORC1, and AMPK pathways differentially according to skeletal muscle type in mouse
Cerda-Kohler, H., Henriquez-Olguín, Carlos, Casas, M., Jensen, Thomas Elbenhardt, Llanos, P. & Jaimovich, E., 2018, In: Physiological Reports. 6, 18, 9 p., e13800.Research output: Contribution to journal › Journal article › Research › peer-review
The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes
Chang, Y., Pownall, S., Jensen, Thomas Elbenhardt, Mouaaz, S., Foltz, W., Zhou, L., Liadis, N., Woo, M., Hao, Z., Dutt, P., Bilan, P. J., Klip, A., Mak, T. & Stambolic, V., 2015, In: eLife. 4, 24 p., e06011.Research output: Contribution to journal › Journal article › Research › peer-review
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Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle
Chiu, T. T., Jensen, Thomas Elbenhardt, Sylow, Lykke, Richter, Erik A. & Klip, A., 2011, In: Cellular Signalling. 23, 10, p. 1546-1554 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Improved glucose homeostatis and enhanced insulin signalling in Grb14-deficient mice
Cooney, G. J., Lyons, R. J., Crew, A. J., Jensen, Thomas Elbenhardt, Molero, J. C., Mitchell, C. J., Biden, T. J., Ormandy, C. J., James, D. E. & Daly, R. J., 2004, In: EMBO Journal. 23, 3, p. 582-593 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TLR2 controls intestinal carcinogen detoxication by CYP1A1
Do, K. N., Fink, L. N., Jensen, Thomas Elbenhardt, Gautier, L. & Parlesak, Alexandr, 2012, In: P L o S One. 7, 3, 7 p., e32309.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates
Ducommun, S., Deak, M., Zeigerer, A., Göransson, O., Seitz, S., Collodet, C., Madsen, A. B., Jensen, Thomas Elbenhardt, Viollet, B., Foretz, M., Gut, P., Sumpton, D. & Sakamoto, Kei, 2019, In: Cellular Signalling. 57, p. 45-57 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans
Fink, L. N., Costford, S. R., Lee, Y. S., Jensen, Thomas Elbenhardt, Bilan, P. J., Oberbach, A., Blüher, M., Olefsky, J. M., Sams, A. & Klip, A., 2014, In: Obesity. 22, 3, p. 747-757 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reducing the mitochondrial oxidative burden alleviates lipid-induced insulin resistance in human skeletal muscle
Fiorenza, Matteo, Onslev, J., Henriquez-Olguín, Carlos, Jensen, Thomas Elbenhardt, Wojtaszewski, Jørgen F P, Hostrup, Morten & Bangsbo, Jens, 12 Apr 2023, bioRxiv, p. 1-39, 39 p.Research output: Working paper › Preprint › Research
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Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle
Fritzen, Andreas Mæchel, Frøsig, C., Jeppesen, J. F., Jensen, Thomas Elbenhardt, Lundsgaard, Anne-Marie, Serup, A. K. L., Schjerling, Peter, Proud, C. G., Richter, Erik A. & Kiens, Bente, 2016, In: Cellular Signalling. 28, 6, p. 663-674 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation
Fritzen, Andreas Mæchel, Madsen, A. L. B., Kleinert, Maximilian, Treebak, Jonas Thue, Lundsgaard, Anne-Marie, Jensen, Thomas Elbenhardt, Richter, Erik A., Wojtaszewski, Jørgen F P, Kiens, Bente & Frøsig, C., 2016, In: Journal of Physiology. 594, 3, p. 745-761 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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AMPK and insulin action: Responses to ageing and high fat diet
Frøsig, C., Jensen, Thomas Elbenhardt, Jeppesen, J., Pehmøller, C., Treebak, Jonas Thue, Maarbjerg, S. J., Kristensen, Jonas Møller, Sylow, L., Alsted, T. J., Schjerling, Peter, Kiens, Bente, Wojtaszewski, Jørgen F P & Richter, Erik A., 2013, In: P L o S One. 8, 5, p. e62338 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes
Gormand, A., Henriksson, E., Ström, K., Jensen, Thomas Elbenhardt, Sakamoto, Kei & Göransson, O., 2011, In: Journal of Cellular Biochemistry. 112, 5, p. 1364-1375 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes
Habets, D. D. J., Coumans, W. A., El Hasnaoui, M., Zarrinpashneh, E., Bertrand, L., Viollet, B., Kiens, Bente, Jensen, Thomas Elbenhardt, Richter, Erik A., Bonen, A., Glatz, J. F. C. & Luiken, J. J. F. P., 2009, In: BBA General Subjects. 1791, 3, p. 212-219 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion
Han, X., Raun, Steffen Henning, Carlsson, Michala, Sjøberg, K. A., Henriquez-Olguín, Carlos, Ali, Mona Sadek, Lundsgaard, Anne-Marie, Fritzen, Andreas Mæchel, Møller, Lisbeth L V, Li, Z., Li, J., Jensen, Thomas Elbenhardt, Kiens, Bente & Sylow, Lykke, 2020, In: Metabolism - Clinical and Experimental. 105, 14 p., 154169.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle
Han, X., Møller, Lisbeth L V, De Groote, E., Bojsen-Møller, K. N., Davey, J., Henriquez-Olguín, Carlos, Li, Z., Knudsen, Jonas Roland, Jensen, Thomas Elbenhardt, Madsbad, Sten, Gregorevic, P., Richter, Erik A. & Sylow, Lykke, 2019, In: Journal of Cachexia, Sarcopenia and Muscle. 10, 6, p. 1241-1257 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms underlying absent training-induced improvement in insulin action in lean, hyperandrogenic women with polycystic ovary syndrome
Hansen, S. L., Bojsen-Møller, K. N., Lundsgaard, Anne-Marie, Hendrich, F. L., Nilas, L., Sjøberg, K. A., Hingst, J. R., Serup, A. K., Henriquez-Olguín, Carlos, Carl, Christian Strini, Wernblad, L. F., Henneberg, M., Lustrup, K. M., Hansen, C., Jensen, Thomas Elbenhardt, Madsbad, Sten, Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2020, In: Diabetes. 69, 11, p. 2267-2280 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NOX2 deficiency exacerbates diet-induced obesity and impairs molecular training adaptations in skeletal muscle
Henriquez-Olguín, Carlos, Meneses Valdés, Roberto Andrés, Raun, Steffen Henning, Gallero, S., Knudsen, Jonas Roland, Li, Z., Li, J., Sylow, Lykke, Jaimovich, E. & Jensen, Thomas Elbenhardt, 2023, In: Redox Biology. 65, 12 p., 102842.Research output: Contribution to journal › Journal article › Research › peer-review
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Compartmentalized muscle redox signals controlling exercise metabolism - Current state, future challenges
Henriquez-Olguín, Carlos, Meneses Valdés, Roberto Andrés & Jensen, Thomas Elbenhardt, 2020, In: Redox Biology. 35, 7 p., 101473.Research output: Contribution to journal › Review › Research › peer-review
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Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
Henriquez-Olguín, Carlos, Knudsen, Jonas Roland, Raun, Steffen Henning, Li, Z., Kellezi, Emilie Dalbram, Treebak, Jonas Thue, Sylow, Lykke, Holmdahl, R., Richter, Erik A., Jaimovich, E. & Jensen, Thomas Elbenhardt, 2019, In: Nature Communications. 10, 11 p., 4623.Research output: Contribution to journal › Journal article › Research › peer-review
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The emerging roles of nicotinamide adenine dinucleotide phosphate oxidase 2 in skeletal muscle redox signaling and metabolism
Henriquez-Olguín, Carlos, Boronat, S., Cabello-Verrugio, C., Jaimovich, E., Hidalgo, E. & Jensen, Thomas Elbenhardt, 2019, In: Antioxidants & Redox Signaling. 31, 8, p. 1371-1410 40 p.Research output: Contribution to journal › Review › Research › peer-review
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Adaptations to high-intensity interval training in skeletal muscle require NADPH oxidase 2
Henriquez-Olguín, Carlos, Baghersad Renani, L., Arab-Ceschia, L., Raun, Steffen Henning, Bhatia, A., Li, Z., Knudsen, Jonas Roland, Holmdahl, R. & Jensen, Thomas Elbenhardt, 2019, In: Redox Biology. 24, 12 p., 101188.Research output: Contribution to journal › Journal article › Research › peer-review
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Global phosphoproteomic analysis of human skeletal muscle reveals a network of exercise-regulated kinases and AMPK substrates
Hoffman, N. J., Parker, B. L., Chaudhuri, R., Fisher-Wellman, K. H., Kleinert, Maximilian, Humphrey, S. J., Yang, P., Holliday, M., Trefely, S., Fazakerley, D. J., Stöckli, J., Burchfield, J. G., Jensen, Thomas Elbenhardt, Jothi, R., Kiens, Bente, Wojtaszewski, Jørgen F P, Richter, Erik A. & James, D. E., 2015, In: Cell Metabolism. 22, 5, p. 922-935 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lipid induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling
Høeg, L. D., Sjøberg, K. A., Jeppesen, J., Jensen, Thomas Elbenhardt, Frøsig, C., Birk, Jesper Bratz, Bisiani, B., Hiscock, N., Pilegaard, Henriette, Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2011, In: Diabetes. 60, 1, p. 64-73 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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AMP-activated protein kinase α2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids
Jelenik, T., Rossmeisl, M., Kuda, O., Jilkova, Z. M., Medrikova, D., Kus, V., Hensler, M., Janovska, P., Miksik, I., Baranowski, M., Gorski, J., Hébrard, S., Jensen, Thomas Elbenhardt, Flachs, P., Hawley, S., Viollet, B. & Kopecky, J., 2010, In: Diabetes. 59, 11, p. 2737-2746 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Large-scale spontaneous self-organization and maturation of skeletal muscle tissues on ultra-compliant gelatin hydrogel substrates
Jensen, J. H., Cakal, S. D., Li, J., Pless, C. J., Radeke, C., Jepsen, M. L., Jensen, Thomas Elbenhardt, Dufva, M. & Lind, J. U., 2020, In: Scientific Reports. 10, 10 p., 13305.Research output: Contribution to journal › Journal article › Research › peer-review
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EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle
Jensen, Thomas Elbenhardt, Leutert, R., Rasmussen, S. T., Mouatt, J. R., Christiansen, M. L. B., Jensen, B. R. & Richter, Erik A., 2012, In: P L o S One. 7, 2, p. e31054 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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When less is more: a simple Western blotting amendment allowing data acquisition on human single fibers
Jensen, Thomas Elbenhardt & Richter, Erik A., 2011, In: Journal of Applied Physiology. 110, 3, p. 583-584 2 p.Research output: Contribution to journal › Editorial › Research
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AMPK alpha1 activation is required for stimulation of glucose uptake by twitch contraction, but not by H2O2, in mouse skeletal muscle
Jensen, Thomas Elbenhardt, Schjerling, Peter, Viollet, B., Wojtaszewski, Jørgen F P & Richter, Erik A., 2008, In: PLoS ONE. 3, 5, 9 p., e2102.Research output: Contribution to journal › Journal article › Research › peer-review
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AMP-activated protein kinase in contraction regulation of skeletal muscle metabolism: necessary and/or sufficient?
Jensen, Thomas Elbenhardt, Wojtaszewski, Jørgen F P & Richter, Erik A., 2009, In: Acta Physiologica (Print Edition). 196, 1, p. 155-174 20 p.Research output: Contribution to journal › Review › Research › peer-review
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Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake
Jensen, Thomas Elbenhardt, Maarbjerg, S. J., Rose, A. J., Leitges, M. & Richter, Erik A., 2009, In: American Journal of Physiology: Endocrinology and Metabolism. 297, 2, p. E340-E348 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain
Jensen, Thomas Elbenhardt, Ross, F. A., Kleinert, Maximilian, Sylow, Lykke, Knudsen, Jonas Roland, Gowans, G. J., Hardie, D. G. & Richter, Erik A., 2015, In: Biochemical Journal. 467, 3, p. 461-472 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Is contraction-stimulated glucose transport feedforward regulated by Ca2+?
Jensen, Thomas Elbenhardt, Angin, Y., Sylow, Lykke & Richter, Erik A., 2014, In: Experimental Physiology. 99, 12, p. 1562-1568 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Caffeine-induced Ca2+ release increases AMPK-dependent glucose uptake in rodent soleus muscle
Jensen, Thomas Elbenhardt, Rose, A. J., Hellsten, Ylva, Wojtaszewski, Jørgen F P & Richter, Erik A., 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 293, 1, p. E286-E292 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of glucose and glycogen metabolism during and after exercise
Jensen, Thomas Elbenhardt & Richter, Erik A., 2012, In: Journal of Physiology. 590, 5, p. 1069-1076 8 p.Research output: Contribution to journal › Review › Research › peer-review
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Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction
Jensen, Thomas Elbenhardt, Rose, A. J., Jørgensen, S. B., Brandt, N., Schjerling, P., Wojtaszewski, Jørgen F P & Richter, Erik A., 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 292, 5, p. E1308-E1317 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca2+ release
Jensen, Thomas Elbenhardt, Sylow, Lykke, Rose, A. J., Madsen, A. L. B., Angin, Y., Maarbjerg, S. J. & Richter, Erik A., 2014, In: Molecular Metabolism. 3, 7, p. 742-753 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Importance of candidate signalling proteins to contraction-stimulated glucose uptake
Jensen, Thomas Elbenhardt, 2008, Copenhagen: Department of Exercise and Sport Sciences, University of Copenhagen. 170 p.Research output: Book/Report › Ph.D. thesis › Research
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Role of AMPK in skeletal muscle gene adaptation in relation to exercise
Jørgensen, S. B., Jensen, Thomas Elbenhardt & Richter, Erik A., 2007, In: Applied Physiology, Nutrition and Metabolism. 32, 5, p. 904-911 8 p.Research output: Contribution to journal › Review › Research › peer-review
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AMPKγ3 Controls Muscle Glucose Uptake in Recovery From Exercise to Recapture Energy Stores
Kido, K., Eskesen, N. O., Henriksen, Nicolai Stevns, Onslev, Johan Dejgaard, Kristensen, Jonas Møller, Larsen, Magnus Romme, Hingst, J. R., Knudsen, Jonas Roland, Birk, Jesper Bratz, Andersen, Nicoline Resen, Jensen, Thomas Elbenhardt, Pehmoller, C., Wojtaszewski, Jørgen F P & Kjøbsted, Rasmus, 2023, In: Diabetes. 72, 10, p. 1397-1408 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise
Klein, D. K., Pilegaard, Henriette, Treebak, Jonas Thue, Jensen, Thomas Elbenhardt, Viollet, B., Schjerling, Peter & Wojtaszewski, Jørgen F P, 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 293, 5, p. E1242-E1249 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training
Kleinert, Maximilian, Parker, B. L., Jensen, Thomas Elbenhardt, Raun, Steffen Henning, Pham, P., Han, X., James, D. E., Richter, Erik A. & Sylow, Lykke, 2018, In: Scientific Reports. 8, 11 p., 10723.Research output: Contribution to journal › Journal article › Research › peer-review
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Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice
Kleinert, Maximilian, Parker, B. L., Fritzen, Andreas Mæchel, Knudsen, Jonas Roland, Jensen, Thomas Elbenhardt, Kjøbsted, Rasmus, Sylow, Lykke, Ruegg, M. A., James, D. E. & Richter, Erik A., 2017, In: Journal of Physiology. 595, 14, p. 4845-4855 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo
Kleinert, Maximilian, Sylow, Lykke, Fazakerley, D. J., Krycer, J. R., Thomas, K. C., Oxbøll, A., Jordy, A. B., Jensen, Thomas Elbenhardt, Yang, G., Schjerling, P., Kiens, Bente, James, D. E., Ruegg, M. A. & Richter, Erik A., 2014, In: Molecular Metabolism. 3, 6, p. 630-641 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., Adamopoulos, I. E., Adeli, K., Adolph, T. E., Adornetto, A., Aflaki, E., Agam, G., Agarwal, A., Aggarwal, B. B., Agnello, M., Agostinis, P. & 2,908 others, , 2021, In: Autophagy. 17, p. 1-382 382 p.Research output: Contribution to journal › Review › Research › peer-review
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Contraction-regulated mTORC1 and protein synthesis: Influence of AMPK and glycogen
Knudsen, Jonas Roland, Li, Z., Persson, K. W., Li, J., Henriquez-Olguín, Carlos & Jensen, Thomas Elbenhardt, 2020, In: Journal of Physiology. 598, 13, p. 2637-2649 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gene deletion of γ-actin impairs insulin-stimulated skeletal muscle glucose uptake in growing mice but not in mature adult mice
Knudsen, Jonas Roland, Madsen, A. B., Li, Z., Andersen, Nicoline Resen, Schjerling, Peter & Jensen, Thomas Elbenhardt, 2022, In: Physiological Reports. 10, 4, 11 p., e15183.Research output: Contribution to journal › Journal article › Research › peer-review
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Growth factor-dependent and -independent activation of mTORC2
Knudsen, Jonas Roland, Fritzen, Andreas Mæchel, James, D. E., Jensen, Thomas Elbenhardt, Kleinert, Maximilian & Richter, Erik A., 2020, In: Trends in Endocrinology and Metabolism. 31, 1, p. 13-24 12 p.Research output: Contribution to journal › Review › Research › peer-review
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The ULK1/2 and AMPK inhibitor SBI-0206965 blocks AICAR and insulin-stimulated glucose transport
Knudsen, Jonas Roland, Madsen, A. B., Persson, K. W., Henriquez-Olguín, Carlos, Li, Z. & Jensen, Thomas Elbenhardt, 2020, In: International Journal of Molecular Sciences . 21, 7, 10 p., 2344.Research output: Contribution to journal › Journal article › Research › peer-review
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Microtubule-mediated GLUT4 trafficking is disrupted in insulin resistant skeletal muscle
Knudsen, Jonas Roland, Persson, K. W., Henriquez-Olguín, Carlos, Li, Z., Di Leo, N., Hesselager, S. A., Raun, Steffen Henning, Hingst, J. R., Trouillon, R., Wohlwend, M., Wojtaszewski, Jørgen F P, Gijs, M. A. M. & Jensen, Thomas Elbenhardt, 2023, In: eLife. 12, 24 p., e83338.Research output: Contribution to journal › Journal article › Research › peer-review
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Exercise increases phosphorylation of the putative mTORC2 activity readout NDRG1 in human skeletal muscle
Knudsen, Jonas Roland, Persson, Kaspar Wredstrøm, Meister, J., Carl, Christian Strini, Raun, Steffen Henning, Andersen, Nicoline Resen, Sylow, Lykke, Kiens, Bente, Jensen, Thomas Elbenhardt, Richter, Erik A. & Kleinert, Maximilian, 2022, In: American Journal of Physiology: Endocrinology and Metabolism. 322, 1, p. E63-E73 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Prior exercise in humans redistributes intramuscular GLUT4 and enhances insulin-stimulated sarcolemmal and endosomal GLUT4 translocation
Knudsen, Jonas Roland, Steenberg, D. E., Hingst, J. R., Hodgson, L. R., Henriquez-Olguín, Carlos, Li, Z., Kiens, Bente, Richter, Erik A., Wojtaszewski, Jørgen F P, Verkade, P. & Jensen, Thomas Elbenhardt, 2020, In: Molecular Metabolism. 39, 9 p., 100998.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microtubule-mediated GLUT4 trafficking is disrupted in insulin resistant skeletal muscle
Knudsen, Jonas Roland, Persson, Kaspar Wredstrøm, Henriquez-Olguín, Carlos, Li, Z., Di Leo, N., Raun, Steffen Henning, Hingst, J. R., Trouillon, R., Wohlwend, M., Wojtaszewski, Jørgen F P, Gijs, M. A. M. & Jensen, Thomas Elbenhardt, 22 Sep 2022, bioRxiv, p. 1-55, 55 p.Research output: Working paper › Preprint › Research
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Electroporated GLUT4-7myc-GFP detects in vivo glucose transporter 4 translocation in skeletal muscle without discernible changes in GFP patterns
Knudsen, Jonas Roland, Henriquez-Olguín, Carlos, Li, Z. & Jensen, Thomas Elbenhardt, 2019, In: Experimental Physiology. 104, 5, p. 704-714 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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AXIN1 knockout does not alter AMPK/mTORC1 regulation and glucose metabolism in mouse skeletal muscle
Li, J., Knudsen, Jonas Roland, Henriquez-Olguín, Carlos, Li, Z., Birk, Jesper Bratz, Persson, Kaspar Wredstrøm, Hellsten, Ylva, Offergeld, A., Jarassier, W., Grand, F. L., Schjerling, P., Wojtaszewski, Jørgen F P & Jensen, Thomas Elbenhardt, 2021, In: Journal of Physiology. 599, 12, p. 3081-3100 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The gut microbiome on a periodized low-protein diet is associated with improved metabolic health
Li, Z., Rasmussen, Torben Sølbeck, Rasmussen, M. L., Li, J., Henriquez-Olguín, Carlos, Kot, W., Nielsen, Dennis Sandris & Jensen, Thomas Elbenhardt, 2019, In: Frontiers in Microbiology. 10, 10 p., 709.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphoproteomic identification of Xin as a novel requirement for skeletal muscle disuse atrophy
Li, Z., Jensen, P., Abrigo, J., Henriquez-Olguín, Carlos, Gingrich, M., Rytter, N., Gliemann, Lasse, Richter, Erik A., Hawke, T., Cabello-Verrugio, C., Larsen, M. R. & Jensen, Thomas Elbenhardt, 28 May 2019, (bioRxiv).Research output: Working paper › Preprint › Research
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Low- and high-protein diets do not alter ex vivo insulin action in skeletal muscle
Li, Z., Rasmussen, M. L., Li, J., Henriquez-Olguín, Carlos, Knudsen, Jonas Roland, Søgaard, O., Madsen, A. L. B. & Jensen, Thomas Elbenhardt, 2018, In: Physiological Reports. 6, 13, 12 p., e13798.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Periodized low protein-high carbohydrate diet confers potent, but transient, metabolic improvements
Li, Z., Rasmussen, M. L., Li, J., Henriquez-Olguín, Carlos, Knudsen, Jonas Roland, Madsen, A. B., Sanchez-Quant, E., Kleinert, Maximilian & Jensen, Thomas Elbenhardt, 2018, In: Molecular Metabolism. 17, p. 112-121 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemical denervation using botulinum toxin increases Akt expression and reduces submaximal insulin-stimulated glucose transport in mouse muscle
Li, Z., Näslund-Koch, L., Henriquez-Olguín, Carlos, Knudsen, Jonas Roland, Li, J., Madsen, A. L. B., Ato, S., Wienecke, Jacob, Ogasawara, R., Nielsen, Jens Bo & Jensen, Thomas Elbenhardt, Jan 2019, In: Cellular Signalling. 53, p. 224-233 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic impairment of AMPK{alpha}2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice
Maarbjerg, S. J., Jørgensen, S. B., Rose, A. J., Jeppesen, J., Jensen, Thomas Elbenhardt, Treebak, Jonas Thue, Birk, Jesper Bratz, Schjerling, Peter, Wojtaszewski, Jørgen F P & Richter, Erik A., 2009, In: American Journal of Physiology: Endocrinology and Metabolism. 297, 4, p. E924-E934 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
β-actin shows limited mobility and is only required for supraphysiological insulin-stimulated glucose transport in young adult soleus muscle
Madsen, A. L. B., Knudsen, Jonas Roland, Henriquez-Olguín, Carlos, Angin, Y., Zaal, K. J., Sylow, Lykke, Schjerling, P., Ralston, E. & Jensen, Thomas Elbenhardt, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 1, p. E110-E125 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo metabolic effects after acute activation of skeletal muscle Gs signaling
Meister, J., Bone, D. B. J., Knudsen, Jonas Roland, Barella, L. F., Liu, L., Lee, R., Gavrilova, O., Chen, M., Weinstein, L. S., Kleinert, Maximilian, Jensen, Thomas Elbenhardt & Wess, J., 2022, In: Molecular Metabolism. 55, 9 p., 101415.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
Meister, J., Bone, D. B. J., Knudsen, Jonas Roland, Barella, L. F., Velenosi, T. J., Akhmedov, D., Lee, R. J., Cohen, A. H., Gavrilova, O., Cui, Y., Karsenty, G., Chen, M., Weinstein, L. S., Kleinert, Maximilian, Berdeaux, R., Jensen, Thomas Elbenhardt, Richter, Erik A. & Wess, J., 2022, In: Nature Communications. 13, 14 p., 22.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action
Molero, J. C., Jensen, Thomas Elbenhardt, Withers, P. C., Couzens, M., Herzog, H., Thien, C. B. F., Langdon, W. Y., Walder, K., Murphy, M. A., Bowtell, D. D. L., James, D. E. & Cooney, G. J., 2004, In: Journal of Clinical Investigation. 114, 9, p. 1326-1333 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
c-Myc overexpression increases ribosome biogenesis and protein synthesis independent of mTORC1 activation in mouse skeletal muscle
Mori, T., Ato, S., Knudsen, Jonas Roland, Henriquez-Olguín, Carlos, Li, Z., Wakabayashi, K., Suginohara, T., Higashida, K., Tamura, Y., Nakazato, K., Jensen, Thomas Elbenhardt & Ogasawara, R., 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 321, 4, p. E551-E559 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle
Murgia, M., Jensen, Thomas Elbenhardt, Cusinato, M., Garcia, M., Richter, Erik A. & Schiaffino, S., 2009, In: Journal of Physiology. 587, 17, p. 4319-4327 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
α-MSH stimulates glucose uptake in mouse muscle and phosphorylates Rab-GTPase-activating protein TBC1D1 independently of AMPK
Møller, C. L., Kjøbsted, Rasmus, Enriori, P. J., Jensen, Thomas Elbenhardt, Garcia-Rudaz, C., Litwak, S. A., Raun, K., Wojtaszewski, Jørgen F P, Wulff, B. S. & Cowley, M. A., 2016, In: P L o S One. 11, 7, 18 p., e0157027.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Rho guanine dissociation inhibitor α inhibits skeletal muscle Rac1 activity and insulin action
Møller, Lisbeth L V, Ali, Mona Sadek, Davey, J., Raun, Steffen Henning, Andersen, Nicoline Resen, Long, J. Z., Qian, H., Jeppesen, J. F., Henriquez-Olguín, Carlos, Frank, E., Jensen, Thomas Elbenhardt, Højlund, K., Wojtaszewski, Jørgen F P, Nielsen, J., Chiu, T. T., Jedrychowski, M. P., Gregorevic, P., Klip, A., Richter, Erik A. & Sylow, Lykke, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 27, 12 p., e2211041120.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The p21-activated kinase 2 (PAK2), but not PAK1, regulates contraction-stimulated skeletal muscle glucose transport
Møller, Lisbeth L V, Nielsen, I. L., Knudsen, Jonas Roland, Andersen, Nicoline Resen, Jensen, Thomas Elbenhardt, Sylow, Lykke & Richter, Erik A., 2020, In: Physiological Reports. 8, 12, 13 p., e14460.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin-stimulated glucose uptake partly relies on p21-activated kinase (PAK)2, but not PAK1, in mouse skeletal muscle
Møller, Lisbeth L V, Jaurji, M., Kjøbsted, Rasmus, Joseph, G. A., Madsen, A. B., Knudsen, Jonas Roland, Lundsgaard, Anne-Marie, Andersen, Nicoline Resen, Schjerling, P., Jensen, Thomas Elbenhardt, Krauss, R. S., Richter, Erik A. & Sylow, Lykke, 2020, In: Journal of Physiology. 598, 23, p. 5351-5377 27 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Resistance exercise-induced hypertrophy: A potential role for rapamycin-insensitive mTOR
Ogasawara, R., Jensen, Thomas Elbenhardt, Goodman, C. A. & Hornberger, T. A., 2019, In: Exercise and Sport Sciences Reviews. 47, 3, p. 188-194Research output: Contribution to journal › Review › Research › peer-review
- Published
Rapamycin and mTORC2 inhibition synergistically reduce contraction-stimulated muscle protein synthesis
Ogasawara, R., Knudsen, Jonas Roland, Li, J., Ato, S. & Jensen, Thomas Elbenhardt, 2020, In: Journal of Physiology. 598, 23, p. 5453-5466 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates
Pérez-Schindler, J., Kohl, B., Schneider-Heieck, K., Leuchtmann, A. B., Henriquez-Olguín, Carlos, Adak, V., Maier, G., Delezie, J., Sakoparnig, T., Vargas-Fernández, E., Karrer-Cardel, B., Ritz, D., Schmidt, A., Hondele, M., Jensen, Thomas Elbenhardt, Hiller, S. & Handschin, C., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 36, 11 p., e2105951118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transparent and cell-guiding cellulose nanofiber 3D printing bioinks
Radeke, C., Pons, R., Mihajlovic, M., Knudsen, Jonas Roland, Butdayev, S., Kempen, Paul Joseph, Segeritz, C., Andresen, T. L., Pehmøller, C. K., Jensen, Thomas Elbenhardt & Lind, J. U., 2023, In: ACS Applied Materials and Interfaces. 15, 2, p. 2564-2577 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adenosine monophosphate-activated protein kinase is elevated in human cachectic muscle and prevents cancer-induced metabolic dysfunction in mice
Raun, Steffen Henning, Ali, Mona Sadek, Han, X., Henriquez-Olguín, Carlos, Pham, Tang Cam Phung, Meneses Valdés, Roberto Andrés, Knudsen, Jonas Roland, Willemsen, A. C. H., Larsen, Steen, Jensen, Thomas Elbenhardt, Langen, R. & Sylow, Lykke, 2023, In: Journal of Cachexia, Sarcopenia and Muscle. 14, 4, p. 1631-1647Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AMPK is elevated in human cachectic muscle and prevents cancer-induced metabolic dysfunction in mice
Raun, Steffen Henning, Ali, Mona Sadek, Han, X., Henriquez-Olguín, Carlos, Pham, Tang Cam Phung, Knudsen, Jonas Roland, Willemsen, A. C. H., Larsen, S., Jensen, Thomas Elbenhardt, Langen, R. & Sylow, Lykke, 7 Jun 2022, bioRxiv, 37 p.Research output: Working paper › Preprint › Research
- Published
Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt
Raun, Steffen Henning, Ali, Mona Sadek, Kjøbsted, Rasmus, Møller, Lisbeth L V, Federspiel, M. A., Richter, Erik A., Jensen, Thomas Elbenhardt & Sylow, Lykke, 2018, In: Journal of Physiology. 596, 12, p. 2283-2299 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cancer causes dysfunctional insulin signaling and glucose transport in a muscle-type-specific manner
Raun, Steffen Henning, Knudsen, Jonas Roland, Han, X., Jensen, Thomas Elbenhardt & Sylow, Lykke, 2022, In: F A S E B Journal. 36, 3, 16 p., e22211.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Ca2+-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions
Rose, A. J., Alsted, T. J., Jensen, Thomas Elbenhardt, Kobberø, J. B., Maarbjerg, S. J., Jensen, J. & Richter, Erik A., 2009, In: Journal of Physiology. 587, 7, p. 1547-1563 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential regulation by AMP and ADP of AMPK complexes containing different γ subunit isoforms
Ross, F. A., Jensen, Thomas Elbenhardt & Hardie, D. G., 2016, In: Biochemical Journal. 473, 2, p. 189-199 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
5'-AMP activated protein kinase is involved in the regulation of myocardial ß-oxidative capacity in mice
Stride, N., Larsen, S., Treebak, Jonas Thue, Hansen, C. N., Hey-Mogensen, M., Speerschneider, T., Jensen, Thomas Elbenhardt, Jeppesen, J., Wojtaszewski, Jørgen F P, Richter, Erik A., Køber, Lars Valeur & Dela, Flemming, 22 Feb 2012, In: Frontiers in Physiology. 3, 7 p., 00033.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1- a novel regulator of contraction-stimulated glucose uptake in skeletal muscle
Sylow, Lykke, Møller, L. L. V., Kleinert, Maximilian, Richter, Erik A. & Jensen, Thomas Elbenhardt, 2014, In: Experimental Physiology. 99, 12, p. 1574-1580 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1 in muscle is dispensable for improved insulin action after exercise in mice
Sylow, Lykke, Møller, Lisbeth L V, D'Hulst, G., Schjerling, P., Jensen, Thomas Elbenhardt & Richter, Erik A., 2016, In: Endocrinology. 157, 8, p. 3009-3015 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reply from Lykke Sylow, Lisbeth L. V. Møller, Maximilian Kleinert, Erik A. Richter and Thomas E. Jensen
Sylow, Lykke, Møller, Lisbeth L V, Kleinert, Maximilian, Richter, Erik A. & Jensen, Thomas Elbenhardt, 2015, In: Journal of Physiology. 593, 9, p. 2239-2240 2 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Rac1 and AMPK account for the majority of muscle glucose uptake stimulated by ex vivo contraction but not in vivo exercise
Sylow, Lykke, Møller, Lisbeth L V, Kleinert, Maximilian, D'Hulst, G., De Groote, E., Schjerling, P., Steinberg, G. R., Jensen, Thomas Elbenhardt & Richter, Erik A., 2017, In: Diabetes. 66, 6, p. 1548-1559 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Akt and Rac1 signalling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance
Sylow, Lykke, Kleinert, Maximilian, Pehmøller, C., Prats Gavalda, Clara, Chiu, T. T., Klip, A., Richter, Erik A. & Jensen, Thomas Elbenhardt, 2014, In: Cellular Signalling. 26, 2, p. 323-331 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle
Sylow, Lykke, Jensen, Thomas Elbenhardt, Kleinert, Maximilian, Højlund, K., Kiens, Bente, Wojtaszewski, Jørgen F P, Prats Gavalda, Clara, Schjerling, P. & Richter, Erik A., 2013, In: Diabetes. 62, 6, p. 1865-1875 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice
Sylow, Lykke, Laurent, I., Kleinert, Maximilian, Møller, Lisbeth L V, Ploug, Thorkil, Schjerling, Peter, Bilan, P. J., Klip, A., Jensen, Thomas Elbenhardt & Richter, Erik A., 2016, In: Journal of Physiology. 594, 17, p. 4997-5008 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle
Sylow, Lykke, Jensen, Thomas Elbenhardt, Kleinert, Maximilian, Mouatt, J. R., Maarbjerg, S. J., Jeppesen, J. F., Prats Gavalda, Clara, Chiu, T. T., Boguslavsky, S., Klip, A., Schjerling, Peter & Richter, Erik A., 2013, In: Diabetes. 62, 4, p. 1139-1151 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stretch-stimulated glucose transport in skeletal muscle is regulated by Rac1
Sylow, Lykke, Møller, L. L. V., Kleinert, Maximilian, Richter, Erik A. & Jensen, Thomas Elbenhardt, 2015, In: Journal of Physiology. 593, 3, p. 645-656 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exercise-stimulated glucose uptake - regulation and implications for glycaemic control
Sylow, Lykke, Kleinert, Maximilian, Richter, Erik A. & Jensen, Thomas Elbenhardt, 2017, In: Nature Reviews Endocrinology. 13, 3, p. 133-148 16 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Protein kinase C {alpha} activity is important for contraction-induced FXYD1 phosphorylation in skeletal muscle
Thomassen, Martin, Rose, A. J., Jensen, Thomas Elbenhardt, Maarbjerg, S. J., Bune, L. T., Leitges, M., Richter, Erik A., Bangsbo, Jens & Nordsborg, Nikolai Baastrup, 2011, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 301, 6, p. R1808-R1814 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits.
Treebak, Jonas Thue, Glund, S., Deshmukh, Atul Shahaji, Klein, D. K., Long, Y. C., Jensen, Thomas Elbenhardt, Jørgensen, S. B., Viollet, B., Andersson, L., Neumann, D., Wallimann, T., Richter, Erik A., Chibalin, A. V., Zierath, J. R. & Wojtaszewski, Jørgen F P, 2006, In: Diabetes. 55, 7, p. 2051-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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AMPK and insulin action: Responses to ageing and high fat diet
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259
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α-MSH stimulates glucose uptake in mouse muscle and phosphorylates Rab-GTPase-activating protein TBC1D1 independently of AMPK
Research output: Contribution to journal › Journal article › Research › peer-review
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258
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The gut microbiome on a periodized low-protein diet is associated with improved metabolic health
Research output: Contribution to journal › Journal article › Research › peer-review
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