Simon Holst Bekker-Jensen
Professor
Molecular Aging Program
Blegdamsvej 3, 2200 København N.
Member of:
Web Track 1: Modifiable pathways of damage and repair in aging
Web: Center for Healthy Aging
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SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling
Airik, R., Schueler, M., Airik, M., Cho, J., Ulanowicz, K. A., Porath, J. D., Hurd, T. W., Bekker-Jensen, Simon Holst, Schrøder, J. M., Andersen, J. S. & Hildebrandt, F., 2016, In: P L o S One. 11, 5, 19 p., e0156081.Research output: Contribution to journal › Journal article › Research › peer-review
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Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response Signaling
Airik, R., Slaats, G. G., Guo, Z., Weiss, A., Khan, N., Ghosh, A., Hurd, T. W., Bekker-Jensen, Simon Holst, Schrøder, J. M., Elledge, S. J., Andersen, J. S., Kispert, A., Castelli, M., Boletta, A., Giles, R. H. & Hildebrandt, F., Nov 2014, In: Journal of the American Society of Nephrology:JASN. 25, 11, p. 2573-83 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein aggregation capture on microparticles enables multi-purpose proteomics sample preparation
Batth, Tanveer Singh, Tollenaere, M. A. X., Rüther, P. L., Gonzalez-Franquesa, A., Prabhakar, B. S., Bekker-Jensen, Simon Holst, Deshmukh, Atul Shahaji & Olsen, Jesper Velgaard, 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 1027-1035Research output: Contribution to journal › Journal article › Research › peer-review
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RNF138 joins the HR team
Bekker-Jensen, Simon Holst & Mailand, Niels, Oct 2015, In: Nature Cell Biology. 17, 11, p. 1375-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks
Bekker-Jensen, Simon Holst, Fugger, K., Danielsen, J. R., Gromova, I., Sehested, M., Celis, J., Bartek, J., Lukas, Jiri & Mailand, Niels, 6 Jul 2007, In: Journal of Biological Chemistry. 282, 27, p. 19638-43 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ubiquitin and the DNA damage response: a new handle on histones
Bekker-Jensen, Simon Holst & Mailand, Niels, 1 Sep 2012, In: Cell Cycle. 11, 17, p. 3153 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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ICLs: a chicken without an egg
Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Reviews. Molecular Cell Biology. 13, 6, p. 342Research output: Contribution to journal › Review › Research › peer-review
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The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks
Bekker-Jensen, Simon Holst & Mailand, Niels, 12 Jun 2011, In: FEBS Letters. 585, p. 2914-2919 6 p.Research output: Contribution to journal › Review › Research › peer-review
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
Bekker-Jensen, Simon Holst, Danielsen, J. M. R., Fugger, K., Gromova, I., Nerstedt, A., Bartek, J., Lukas, Jiri & Mailand, Niels, 2010, In: Nature Cell Biology. 12, 1, p. 80-6; sup pp 1-12Research output: Contribution to journal › Letter › Research › peer-review
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Assembly and function of DNA double-strand break repair foci in mammalian cells
Bekker-Jensen, Simon Holst & Mailand, Niels, 10 Dec 2010, In: D N A Repair. 9, 12, p. 1219-28 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
Borisova, M. E., Voigt, A., Tollenaere, M. A. X., Sahu, S. K., Juretschke, T., Kreim, N., Mailand, Niels, Choudhary, Chunaram, Bekker-Jensen, Simon Holst, Akutsu, M., Wagner, S. A. & Beli, P., 1 Dec 2018, In: Nature Communications. 9, p. 1-16 16 p., 1017.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
Bursomanno, S., Beli, P., Khan, A. M., Minocherhomji, S., Wagner, S. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Hickson, Ian David & Liu, Ying, Jan 2015, In: DNA Repair. 25, p. 84-96 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection
Carson, C. T., Orazio, N. I., Lee, D. V., Suh, J., Bekker-Jensen, Simon Holst, Araujo, F. D., Lakdawala, S. S., Lilley, C. E., Bartek, J., Lukas, Jiri & Weitzman, M. D., 2009, In: EMBO Journal. 28, 6, p. 652-62 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PRMT5-mediated regulatory arginine methylation of RIPK3
Chauhan, C., Martinez Del Val, Ana, Niedenthal, R., Olsen, Jesper Velgaard, Kotlyarov, A., Bekker-Jensen, Simon Holst, Gaestel, M. & Menon, M. B., 2023, In: Cell Death Discovery. 9, 9 p., 14.Research output: Contribution to journal › Journal article › Research › peer-review
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The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity
Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W., Fiil, Berthe Katrine, Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, Simon Holst, Mailand, Niels, Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, Mads, 2012, In: Molecular Cell. 46, 6, p. 746-58 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling
Damgaard, R. B., Fiil, Berthe Katrine, Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, Simon Holst, Jost, P. J., Ehl, S., Mailand, Niels & Gyrd-Hansen, Mads, 1 Jul 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level
Danielsen, J. M. R., Sylvestersen, K. B., Bekker-Jensen, Simon Holst, Szklarczyk, D., Poulsen, J. W., Horn, H., Jensen, Lars Juhl, Mailand, Niels & Nielsen, Michael Lund, 1 Mar 2011, In: Molecular and Cellular Proteomics. 10, 3, p. M110.003590Research output: Contribution to journal › Journal article › Research › peer-review
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DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger
Danielsen, J. M. R., Povlsen, L. K., Villumsen, B. H., Streicher, W., Nilsson, Jakob, Wikström, M., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Journal of Cell Biology. 197, 2, p. 179-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO
Diehl, C., Akke, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Streicher, W. & Wikström, M., 10 Jun 2016, In: Journal of Biological Chemistry. 291, 24, p. 12658-12672 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Histone displacement during nucleotide excision repair
Dinant, C., Bartek, J. & Bekker-Jensen, Simon Holst, 17 Oct 2012, In: International Journal of Molecular Sciences (Online). 13, 10, p. 13322-13337 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
Doil, C., Mailand, Niels, Bekker-Jensen, Simon Holst, Ménard, Patrice, Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 2009, In: Cell. 136, 3, p. 435-46 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin
Faustrup, H., Bekker-Jensen, Simon Holst, Bartek, J., Lukas, Jiri & Mailand, Niels, 2009, In: Journal of Cell Biology. 184, 1, p. 13-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling
Fiil, Berthe Katrine, Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Komander, D. & Gyrd-Hansen, Mads, 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage
Gibbs-Seymour, I., Oka, Y., Rajendra, E., Weinert, B. T., Passmore, L. A., Patel, K. J., Olsen, Jesper Velgaard, Choudhary, Chunaram, Bekker-Jensen, Simon Holst & Mailand, Niels, Jan 2015, In: Molecular Cell. 57, 1, p. 150-64 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage
Gibbs-Seymour, I., Markiewicz, E., Bekker-Jensen, Simon Holst, Mailand, Niels & Hutchison, C. J., Apr 2015, In: Aging Cell. 14, 2, p. 162-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 14470936
Most downloads
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2010
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Research output: Contribution to journal › Journal article › Research › peer-review
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902
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Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage
Research output: Contribution to journal › Letter › Research › peer-review
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464
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TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
Research output: Contribution to journal › Journal article › Research › peer-review
Published