Vilhelm Bohr
Affiliate professor, Affiliate Professor
Molecular Aging Program
Panum Instituttet, Blegdamsvej 3, 2200 København N, 07 Bygning 7, Building: 07-3-13
Member of:
- Published
DNA repair deficiency in neurodegeneration
Jeppesen, D. K., Bohr, Vilhelm & Stevnsner, T. V., 30 Apr 2011, In: Progress in Neurobiology. 94, 2, p. 166-200 35 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients
Jensen, M. B., Dunn, C. A., Keijzers, G., Kulikowicz, T., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2012, In: Aging. 4, 11, p. 790-802 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitochondrial OGG1 expression reduces age-associated neuroinflammation by regulating cytosolic mitochondrial DNA
Hussain, M., Chu, X., Duan Sahbaz, B., Gray, S., Pekhale, K., Park, J. H., Croteau, D. L. & Bohr, Vilhelm, 2023, In: Free Radical Biology and Medicine. 203, p. 34-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING
Hou, Y., Wei, Y., Lautrup, S., Yang, B., Wang, Y., Cordonnier, S., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 37, e2011226118.Research output: Contribution to journal › Journal article › Research › peer-review
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Ageing as a risk factor for neurodegenerative disease
Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, Steen, Croteau, D. L. & Bohr, Vilhelm, 2019, In: Nature Reviews. Neurology. 15, 10, p. 565-581 17 p.Research output: Contribution to journal › Review › Research › peer-review
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NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., Stevnsner, T. V., Mattson, M. P. & Bohr, Vilhelm, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. E1876-E1885Research output: Contribution to journal › Journal article › Research › peer-review
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RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice
Hou, Y., Park, J. H., Dan, X., Chu, X., Yang, B., Hussain, M., Croteau, D. L. & Bohr, Vilhelm, 2023, In: Neurobiology of Disease. 180, 11 p., 106092.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome instability in Alzheimer disease
Hou, Y., Song, H., Croteau, D. L., Akbari, M. & Bohr, Vilhelm, Jan 2017, In: Mechanisms of Ageing and Development. 161, part A, p. 83-94 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function
Hey-Mogensen, M., Gram, M., Jensen, M. B., Lund, M. T., Hansen, C. N., Scheibye-Knudsen, Morten, Bohr, Vilhelm & Dela, Flemming, 1 Sep 2015, In: The Journal of Physiology. 593, 17, p. 3991-4010 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuropsychological Sequelae in 91 Cases of Pneumococcal Meningitis
Gade, A., Bohr, Vilhelm, Bohr, Vilhelm, Bjerrum, J., Udesen, H. & Mortensen, Erik Lykke, 1 Jan 1992, In: Developmental Neuropsychology. 8, 4, p. 447-457 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitophagy in neurodegeneration and aging
Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, Morten, Stevnsner, T., Nilsen, H., Bohr, Vilhelm & Fang, E. F., 2017, In: Neurochemistry International. 109, p. 202-209Research output: Contribution to journal › Review › Research › peer-review
Emerging Antitumor Activities of the Bitter Melon (Momordica charantia)
Fang, E. F., Froetscher, L., Scheibye-Knudsen, Morten, Bohr, Vilhelm, Wong, J. H. & Ng, T. B., 2019, In: Current Protein and Peptide Science. 20, 3, p. 296-301 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Nuclear DNA damage signalling to mitochondria in ageing
Fang, E. F., Scheibye-Knudsen, Morten, Chua, K. F., Mattson, M. P., Croteau, D. L. & Bohr, Vilhelm, May 2016, In: Nature Reviews. Molecular Cell Biology. 17, 5, p. 308-321 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., Iser, W. B., Eckley, D. M., Zhang, Y., Lehrmann, E., Goldberg, I. G., Scheibye-Knudsen, Morten, Mattson, M. P., Nilsen, H., Bohr, Vilhelm & Becker, K. G., 2017, In: Scientific Reports. 7, 46208.Research output: Contribution to journal › Journal article › Research › peer-review
A research agenda for aging in China in the 21st century
Fang, E. F., Scheibye-Knudsen, Morten, Jahn, H. J., Li, J., Ling, L., Guo, H., Zhu, X., Preedy, V., Lu, H., Bohr, Vilhelm, Chan, W. Y., Liu, Y. & Ng, T. B., Nov 2015, In: Ageing Research Reviews. 24, Pt B, p. 197-205 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction
Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L. & Bohr, Vilhelm, 8 May 2014, In: Cell. 157, 4, p. 882-96 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., Iser, W. B., Wollman, B. N., Morevati, M., Li, J., Kerr, J. S., Lu, Q., Waltz, T. B., Tian, J., Sinclair, D. A., Mattson, M. P. & 2 others, , 11 Oct 2016, In: Cell Metabolism. 24, 4, p. 566-581 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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NAD+ in Aging: Molecular Mechanisms and Translational Implications
Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P. & Bohr, Vilhelm, 2017, In: Trends in Molecular Medicine. 23, 10, p. 899-916 18 p.Research output: Contribution to journal › Review › Research › peer-review
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In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice
Fang, E. F., Palikaras, K., Sun, N., Fivenson, E. M., Spangler, R. D., Kerr, J. S., Cordonnier, S. A., Hou, Y., Dombi, E., Kassahun, H., Tavernarakis, N., Poulton, J., Nilsen, H. & Bohr, Vilhelm, 2017, In: Journal of Visualized Experiments. 129, e56301.Research output: Contribution to journal › Journal article › Research › peer-review
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NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., Figueroa, D., Morevati, M., Lee, H-J., Kato, H., Kassahun, H., Lee, J-H., Filippelli, D., Okur, M. N., Mangerich, A., Croteau, D. L. & 9 others, , 2019, In: Nature Communications. 10, 1, 18 p., 5284.Research output: Contribution to journal › Journal article › Research › peer-review
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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., Rocktäschel, P., Croteau, D. L., Akbari, M., Greig, N. H., Fladby, T., Nilsen, H., Cader, M. Z., Mattson, M. P., Tavernarakis, N. & Bohr, Vilhelm, 2019, In: Nature Neuroscience. 22, p. 401-412Research output: Contribution to journal › Journal article › Research › peer-review
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Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis
Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Desler, Claus, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, L. H. & Rasmussen, Lene Juel, 2017, In: Scientific Reports. 7, 14 p., 12480.Research output: Contribution to journal › Journal article › Research › peer-review
Toward understanding genomic instability, mitochondrial dysfunction and aging
Fakouri, N. B., Hou, Y., Demarest, T. G., Christiansen, L. S., Okur, M. N., Mohanty, J. G., Croteau, D. L. & Bohr, Vilhelm, 2019, In: F E B S Journal. 286, 6, p. 1058-1073 16 p.Research output: Contribution to journal › Review › Research › peer-review
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Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase
Duan, S., Han, X., Akbari, M., Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 2020, In: Nucleic Acids Research. 48, 12, p. 6530–6546Research output: Contribution to journal › Journal article › Research › peer-review
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Mitochondrial DNA repair and association with aging--an update
Diaz, R. G., Bohr, Vilhelm & Stevnsner, T. V., 1 Aug 2010, In: Experimental Gerontology. 45, 7-8, p. 478-88 11 p.Research output: Contribution to journal › Review › Research › peer-review
ID: 4975983
Most downloads
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298
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Mitochondria in the signaling pathways that control longevity and health span
Research output: Contribution to journal › Review › Research › peer-review
Published -
281
downloads
Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
251
downloads
Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis
Research output: Contribution to journal › Journal article › Research › peer-review
Published