A role for interleukin-33 in T(H)2-polarized intestinal inflammation?
Research output: Contribution to journal › Review › Research › peer-review
Interleukin 33 (IL-33) is a recently discovered cytokine member of the IL-1 superfamily that is widely expressed in fixed tissue cells, including endothelial and epithelial cells. IL-33 induces helper T cells, mast cells, eosinophils, and basophils to produce type-2 cytokines through binding to the ST2/IL-1 receptor accessory protein complex. Recent studies have shown IL-33 to be upregulated in intestinal parasite infection and in epithelial cells and myofibroblasts in ulcerative colitis (UC). The findings point to a role for IL-33 in directing the T(H)2-type immune responses in these types of mucosal inflammation. As the IL-33/ST2 receptor axis can be manipulated by various blocking antibodies, this could be a potential therapeutic target in the future treatment of UC.
Original language | English |
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Journal | Mucosal Immunology |
Volume | 4 |
Issue number | 5 |
Pages (from-to) | 496-502 |
Number of pages | 7 |
ISSN | 1933-0219 |
DOIs | |
Publication status | Published - Sep 2011 |
- Animals, Colitis, Ulcerative/genetics, Gene Expression Regulation/immunology, Humans, Inflammatory Bowel Diseases/genetics, Interleukin-33, Interleukins/genetics, Intestinal Mucosa/immunology, Receptors, Interleukin-1/metabolism, Signal Transduction/genetics, Th2 Cells/immunology
Research areas
ID: 260306498