The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition. / Zonderland, Gijs; Vanzo, Riccardo; Amitash, Sampath; Martín-Doncel, Elena; Coscia, Fabian; Mund, Andreas; Lerdrup, Mads; Benada, Jan; Boos, Dominik; Toledo, Luis.

In: Molecular Cell, Vol. 82, No. 18, 2022, p. 3350-3365.e7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zonderland, G, Vanzo, R, Amitash, S, Martín-Doncel, E, Coscia, F, Mund, A, Lerdrup, M, Benada, J, Boos, D & Toledo, L 2022, 'The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition', Molecular Cell, vol. 82, no. 18, pp. 3350-3365.e7. https://doi.org/10.1016/j.molcel.2022.08.006

APA

Zonderland, G., Vanzo, R., Amitash, S., Martín-Doncel, E., Coscia, F., Mund, A., Lerdrup, M., Benada, J., Boos, D., & Toledo, L. (2022). The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition. Molecular Cell, 82(18), 3350-3365.e7. https://doi.org/10.1016/j.molcel.2022.08.006

Vancouver

Zonderland G, Vanzo R, Amitash S, Martín-Doncel E, Coscia F, Mund A et al. The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition. Molecular Cell. 2022;82(18):3350-3365.e7. https://doi.org/10.1016/j.molcel.2022.08.006

Author

Zonderland, Gijs ; Vanzo, Riccardo ; Amitash, Sampath ; Martín-Doncel, Elena ; Coscia, Fabian ; Mund, Andreas ; Lerdrup, Mads ; Benada, Jan ; Boos, Dominik ; Toledo, Luis. / The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition. In: Molecular Cell. 2022 ; Vol. 82, No. 18. pp. 3350-3365.e7.

Bibtex

@article{7e1b446f4e8f4627ba9880015cd525e2,

title = "The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition",

abstract = "It has been proposed that ATR kinase senses the completion of DNA replication to initiate the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex prevents a premature entry into G2 from early S-phase independently of ATR/CHK1 kinases. TRESLIN-MTBP acts transiently at pre-replication complexes (preRCs) to initiate origin firing and is released after the subsequent recruitment of CDC45. This dynamic behavior of TRESLIN-MTBP implements a monitoring system that checks the activation of replication forks and senses the rate of origin firing to prevent the entry into G2. This system detects the decline in the number of origins of replication that naturally occurs in very late S, which is the signature that cells use to determine the completion of DNA replication and permit the S/G2 transition. Our work introduces TRESLIN-MTBP as a key player in cell-cycle control independent of canonical checkpoints.",

keywords = "ATR, cell cycle, checkpoint, CHK1, DNA replication, MTBP, origin firing, S/G2 transition, TRESLIN",

author = "Gijs Zonderland and Riccardo Vanzo and Sampath Amitash and Elena Mart{\'i}n-Doncel and Fabian Coscia and Andreas Mund and Mads Lerdrup and Jan Benada and Dominik Boos and Luis Toledo",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

doi = "10.1016/j.molcel.2022.08.006",

language = "English",

volume = "82",

pages = "3350--3365.e7",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "18",

}

RIS

TY - JOUR

T1 - The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition

AU - Zonderland, Gijs

AU - Vanzo, Riccardo

AU - Amitash, Sampath

AU - Martín-Doncel, Elena

AU - Coscia, Fabian

AU - Mund, Andreas

AU - Lerdrup, Mads

AU - Benada, Jan

AU - Boos, Dominik

AU - Toledo, Luis

PY - 2022

Y1 - 2022

N2 - It has been proposed that ATR kinase senses the completion of DNA replication to initiate the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex prevents a premature entry into G2 from early S-phase independently of ATR/CHK1 kinases. TRESLIN-MTBP acts transiently at pre-replication complexes (preRCs) to initiate origin firing and is released after the subsequent recruitment of CDC45. This dynamic behavior of TRESLIN-MTBP implements a monitoring system that checks the activation of replication forks and senses the rate of origin firing to prevent the entry into G2. This system detects the decline in the number of origins of replication that naturally occurs in very late S, which is the signature that cells use to determine the completion of DNA replication and permit the S/G2 transition. Our work introduces TRESLIN-MTBP as a key player in cell-cycle control independent of canonical checkpoints.

AB - It has been proposed that ATR kinase senses the completion of DNA replication to initiate the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex prevents a premature entry into G2 from early S-phase independently of ATR/CHK1 kinases. TRESLIN-MTBP acts transiently at pre-replication complexes (preRCs) to initiate origin firing and is released after the subsequent recruitment of CDC45. This dynamic behavior of TRESLIN-MTBP implements a monitoring system that checks the activation of replication forks and senses the rate of origin firing to prevent the entry into G2. This system detects the decline in the number of origins of replication that naturally occurs in very late S, which is the signature that cells use to determine the completion of DNA replication and permit the S/G2 transition. Our work introduces TRESLIN-MTBP as a key player in cell-cycle control independent of canonical checkpoints.

KW - ATR

KW - cell cycle

KW - checkpoint

KW - CHK1

KW - DNA replication

KW - MTBP

KW - origin firing

KW - S/G2 transition

KW - TRESLIN

U2 - 10.1016/j.molcel.2022.08.006

DO - 10.1016/j.molcel.2022.08.006

M3 - Journal article

C2 - 36049481

AN - SCOPUS:85138058778

VL - 82

SP - 3350-3365.e7

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 18

ER -

ID: 321473826