TY - JOUR

T1 - The association between alcohol consumption and contact sensitization in Danish adults: the Glostrup Allergy Study

AU - Thyssen, Jacob Pontoppidan

AU - Nielsen, N.H.

AU - Linneberg, A.

N1 - Times Cited: 0ArticleEnglishThyssen, J. PGentofte Univ Hosp, Dept Dermatol, Natl Allergy Res Ctr, Ledreborg Alle 10 1, DK-2820 Gentofte, DenmarkCited References Count: 52253BZBLACKWELL PUBLISHING9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLANDOXFORD

PY - 2008

Y1 - 2008

N2 - Background Population-based epidemiological studies have indicated that alcohol consumption is associated with IgE-mediated immune diseases (i.e. allergic rhinitis, asthma and urticaria). These studies have been strongly supported by several immunological studies. Furthermore, an inhibitory effect of alcohol consumption on the development of delayed-type hypersensitivity has been shown in healthy controls. However, a possible association between contact sensitization and alcohol consumption in a general population has never been reported. Objectives To investigate whether alcohol consumption is associated with contact sensitization in a general population. Methods In 1990, self-reported consumption of alcohol and patch testing results were assessed in 1112 subjects, aged 15-69 years, participating in a population-based cross-sectional study in Glostrup, Denmark. In 1998, they were invited to a follow-up and 734 were re-examined (participation rate 69.0%). Adjustment for potential confounders was performed by using logistic regression analyses. Results Women who reported no consumption of alcoholic drinks per week were more likely to develop contact sensitization (adjusted odds ratio 2.12, 95% confidence interval 0.98-4.61) during a 8-year follow-up period. A positive trend among women was detected (P = 0.045). Conclusions These data support the hypothesis that alcohol consumption leads to IgE-mediated immune responses rather than delayed-type hypersensitivity reactions. It is probable that alcohol consumption prevents the development of contact sensitization. Further epidemiological studies are warranted Udgivelsesdato: 2008/2

AB - Background Population-based epidemiological studies have indicated that alcohol consumption is associated with IgE-mediated immune diseases (i.e. allergic rhinitis, asthma and urticaria). These studies have been strongly supported by several immunological studies. Furthermore, an inhibitory effect of alcohol consumption on the development of delayed-type hypersensitivity has been shown in healthy controls. However, a possible association between contact sensitization and alcohol consumption in a general population has never been reported. Objectives To investigate whether alcohol consumption is associated with contact sensitization in a general population. Methods In 1990, self-reported consumption of alcohol and patch testing results were assessed in 1112 subjects, aged 15-69 years, participating in a population-based cross-sectional study in Glostrup, Denmark. In 1998, they were invited to a follow-up and 734 were re-examined (participation rate 69.0%). Adjustment for potential confounders was performed by using logistic regression analyses. Results Women who reported no consumption of alcoholic drinks per week were more likely to develop contact sensitization (adjusted odds ratio 2.12, 95% confidence interval 0.98-4.61) during a 8-year follow-up period. A positive trend among women was detected (P = 0.045). Conclusions These data support the hypothesis that alcohol consumption leads to IgE-mediated immune responses rather than delayed-type hypersensitivity reactions. It is probable that alcohol consumption prevents the development of contact sensitization. Further epidemiological studies are warranted Udgivelsesdato: 2008/2

U2 - 10.1111/j.1365-2133.2007.08336.x

DO - 10.1111/j.1365-2133.2007.08336.x

M3 - Journal article

C2 - 18067484

VL - 158

SP - 306

EP - 312

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 2

ER -