Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases
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Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases. / Lim, Hooi Ching; Couchman, John Robert.
In: BBA General Subjects, Vol. 1840, No. 8, 18.01.2014, p. 2482–2490.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases
AU - Lim, Hooi Ching
AU - Couchman, John Robert
N1 - Copyright © 2014 Elsevier B.V. All rights reserved.
PY - 2014/1/18
Y1 - 2014/1/18
N2 - While syndecan-2 is usually considered a mesenchymal transmembrane proteoglycan, it can be upregulated in some tumour cells, such as the malignant breast carcinoma cell line, MDA-MB231. Depletion of this syndecan by siRNA, but not other syndecans, has a marked effect on cell morphology, increasing spreading, microfilament bundle and focal adhesion formation, with reduced cell migration.
AB - While syndecan-2 is usually considered a mesenchymal transmembrane proteoglycan, it can be upregulated in some tumour cells, such as the malignant breast carcinoma cell line, MDA-MB231. Depletion of this syndecan by siRNA, but not other syndecans, has a marked effect on cell morphology, increasing spreading, microfilament bundle and focal adhesion formation, with reduced cell migration.
U2 - 10.1016/j.bbagen.2014.01.018
DO - 10.1016/j.bbagen.2014.01.018
M3 - Journal article
C2 - 24447566
VL - 1840
SP - 2482
EP - 2490
JO - B B A - General Subjects
JF - B B A - General Subjects
SN - 0304-4165
IS - 8
ER -
ID: 109872808