Risk factors for potential drug interactions in general practice

Research output: Contribution to journalJournal articleResearchpeer-review

Objective: To identify patient- and practice-related factors associated with potential drug interactions. Methods: A register
analysis study in general practices in the county of Funen, Denmark. Prescription data were retrieved from a populationbased
prescription database (Odense University Pharmacoepidemiologic Database, OPED) covering prescriptions to all
inhabitants in the county of Funen, Denmark. All individuals exposed to concurrent use of two or more drugs
(polypharmacy) were identified. Combinations of drugs with potential interactions were registered and classified as major,
moderate, or minor, depending on the severity of outcome and the quality of documentation. A two-level random coefficient
logistic regression model was used to investigate factors related to potential drug interactions. Results: One-third of the
population was exposed to polypharmacy, and 6% were exposed to potential drug interactions during 1 year. Patient factors
associated with increased risk of potential drug interactions were high age, a high number of concurrently used drugs, and a
high number of prescribers. Practice factors associated with potential drug interactions were a high percentage of elderly
patients and a low percentage of female patients listed.
Conclusion: Prescription data may be useful in quality-improvement programmes to identify groups of patients and
practices at increased risk of drug interactions.
Original languageEnglish
JournalEuropean Journal of General Practice
Pages (from-to)1-7
Number of pages7
Publication statusPublished - 2007
Externally publishedYes

ID: 18686071