Risk factors for potential drug interactions in general practice
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Risk factors for potential drug interactions in general practice. / Bjerrum, Lars; Lopez-Valcarcel, Beatriz Gonzalez.
In: European Journal of General Practice, 2007, p. 1-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Risk factors for potential drug interactions in general practice
AU - Bjerrum, Lars
AU - Lopez-Valcarcel, Beatriz Gonzalez
PY - 2007
Y1 - 2007
N2 - Objective: To identify patient- and practice-related factors associated with potential drug interactions. Methods: A registeranalysis study in general practices in the county of Funen, Denmark. Prescription data were retrieved from a populationbasedprescription database (Odense University Pharmacoepidemiologic Database, OPED) covering prescriptions to allinhabitants in the county of Funen, Denmark. All individuals exposed to concurrent use of two or more drugs(polypharmacy) were identified. Combinations of drugs with potential interactions were registered and classified as major,moderate, or minor, depending on the severity of outcome and the quality of documentation. A two-level random coefficientlogistic regression model was used to investigate factors related to potential drug interactions. Results: One-third of thepopulation was exposed to polypharmacy, and 6% were exposed to potential drug interactions during 1 year. Patient factorsassociated with increased risk of potential drug interactions were high age, a high number of concurrently used drugs, and ahigh number of prescribers. Practice factors associated with potential drug interactions were a high percentage of elderlypatients and a low percentage of female patients listed.Conclusion: Prescription data may be useful in quality-improvement programmes to identify groups of patients andpractices at increased risk of drug interactions.
AB - Objective: To identify patient- and practice-related factors associated with potential drug interactions. Methods: A registeranalysis study in general practices in the county of Funen, Denmark. Prescription data were retrieved from a populationbasedprescription database (Odense University Pharmacoepidemiologic Database, OPED) covering prescriptions to allinhabitants in the county of Funen, Denmark. All individuals exposed to concurrent use of two or more drugs(polypharmacy) were identified. Combinations of drugs with potential interactions were registered and classified as major,moderate, or minor, depending on the severity of outcome and the quality of documentation. A two-level random coefficientlogistic regression model was used to investigate factors related to potential drug interactions. Results: One-third of thepopulation was exposed to polypharmacy, and 6% were exposed to potential drug interactions during 1 year. Patient factorsassociated with increased risk of potential drug interactions were high age, a high number of concurrently used drugs, and ahigh number of prescribers. Practice factors associated with potential drug interactions were a high percentage of elderlypatients and a low percentage of female patients listed.Conclusion: Prescription data may be useful in quality-improvement programmes to identify groups of patients andpractices at increased risk of drug interactions.
U2 - 10.1080/13814780701815116
DO - 10.1080/13814780701815116
M3 - Journal article
C2 - 18464169
SP - 1
EP - 7
JO - European Journal of General Practice
JF - European Journal of General Practice
SN - 1381-4788
ER -
ID: 18686071