Protein-Protein Interaction Databases

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Years of meticulous curation of scientific literature and increasingly reliable computational predictions have resulted in creation of vast databases of protein interaction data. Over the years, these repositories have become a basic framework in which experiments are analyzed and new directions of research are explored. Here we present an overview of the most widely used protein-protein interaction databases and the methods they employ to gather, combine, and predict interactions. We also point out the trade-off between comprehensiveness and accuracy and the main pitfall scientists have to be aware before adopting protein interaction databases in any single-gene or genome-wide analysis.

Original languageEnglish
Title of host publicationProtein-Protein Interactions : Methods and Applications
EditorsCheryl L. Meyerkord, Haian Fu
Number of pages18
Place of PublicationNew York
PublisherSpringer Publishing Company
Publication date2015
ISBN (Print)978-1-4939-2424-0
ISBN (Electronic)978-1-4939-2425-7
Publication statusPublished - 2015
SeriesMethods in Molecular Biology

ID: 141012425