Protein-Protein Interaction Databases
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Protein-Protein Interaction Databases. / Szklarczyk, Damian; Jensen, Lars Juhl.
Protein-Protein Interactions: Methods and Applications. ed. / Cheryl L. Meyerkord; Haian Fu. Vol. 1278 2. ed. New York : Springer Publishing Company, 2015. p. 39-56 (Methods in Molecular Biology, Vol. 1278).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Protein-Protein Interaction Databases
AU - Szklarczyk, Damian
AU - Jensen, Lars Juhl
PY - 2015
Y1 - 2015
N2 - Years of meticulous curation of scientific literature and increasingly reliable computational predictions have resulted in creation of vast databases of protein interaction data. Over the years, these repositories have become a basic framework in which experiments are analyzed and new directions of research are explored. Here we present an overview of the most widely used protein-protein interaction databases and the methods they employ to gather, combine, and predict interactions. We also point out the trade-off between comprehensiveness and accuracy and the main pitfall scientists have to be aware before adopting protein interaction databases in any single-gene or genome-wide analysis.
AB - Years of meticulous curation of scientific literature and increasingly reliable computational predictions have resulted in creation of vast databases of protein interaction data. Over the years, these repositories have become a basic framework in which experiments are analyzed and new directions of research are explored. Here we present an overview of the most widely used protein-protein interaction databases and the methods they employ to gather, combine, and predict interactions. We also point out the trade-off between comprehensiveness and accuracy and the main pitfall scientists have to be aware before adopting protein interaction databases in any single-gene or genome-wide analysis.
U2 - 10.1007/978-1-4939-2425-7_3
DO - 10.1007/978-1-4939-2425-7_3
M3 - Book chapter
C2 - 25859942
SN - 978-1-4939-2424-0
VL - 1278
T3 - Methods in Molecular Biology
SP - 39
EP - 56
BT - Protein-Protein Interactions
A2 - Meyerkord, Cheryl L.
A2 - Fu, Haian
PB - Springer Publishing Company
CY - New York
ER -
ID: 141012425