Possible misinterpretation of penicillin susceptibility in Staphylococcus aureus blood isolate due to in vitro loss of the blaZ gene
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We describe a case of recurrent catheter-related blood stream infections (BSI) with Staphylococcusaureus, in which the first isolate tested susceptible to penicillin, while subsequent isolates were resistant. Phenotypic susceptibility correlated with the absence/presence of the blaZ gene. The in vitro stability of penicillin resistance was investigated by subculturing single colonies. In two out of five colonies, phenotypical resistance was lost after a single subculture, which correlated with loss of the blaZ gene. This in vitro phenomenon probably resulted in a very major error in the microbiology report of the first BSI, where penicillin had been recommended as treatment.
|Journal||European Journal of Clinical Microbiology and Infectious Diseases|
|Number of pages||5|
|Publication status||Published - 2022|
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
- blaZ, In vitro susceptibility testing, PSSA PRSA, Staphylococcus aureus