Possible misinterpretation of penicillin susceptibility in Staphylococcus aureus blood isolate due to in vitro loss of the blaZ gene
Research output: Contribution to journal › Journal article › Research › peer-review
We describe a case of recurrent catheter-related blood stream infections (BSI) with Staphylococcusaureus, in which the first isolate tested susceptible to penicillin, while subsequent isolates were resistant. Phenotypic susceptibility correlated with the absence/presence of the blaZ gene. The in vitro stability of penicillin resistance was investigated by subculturing single colonies. In two out of five colonies, phenotypical resistance was lost after a single subculture, which correlated with loss of the blaZ gene. This in vitro phenomenon probably resulted in a very major error in the microbiology report of the first BSI, where penicillin had been recommended as treatment.
Original language | English |
---|---|
Journal | European Journal of Clinical Microbiology and Infectious Diseases |
Volume | 41 |
Issue number | 1 |
Pages (from-to) | 163-167 |
Number of pages | 5 |
ISSN | 0934-9723 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
- blaZ, In vitro susceptibility testing, PSSA PRSA, Staphylococcus aureus
Research areas
ID: 313705552