Phenazines and natural products; novel synthesis of saphenic acid

Research output: Contribution to journalJournal articleResearchpeer-review

The natural product saphenic acid (6-(1-hydroxyethyl)1- phenazinecarboxylic acid) was synthesized from readily accessible starting materials. The desired product was obtained in an overall yield of 22% for four steps with the key steps being formation of a diphenylamine, followed by cyclization under alkaline and reducing conditions. Assignments of 1H NMR spectra were achieved by homo- and heteronuclear 1D and 2D correlations. Double pulsed field gradient spin-echo one-dimensional NOESY proved especially valuable for assignment of aromatic protons.

Original languageEnglish
Issue number10
Pages (from-to)1763-1766
Number of pages4
Publication statusPublished - 1 Jan 1999

    Research areas

  • Antibiotics, DPFGSE-NOE, Heterocycles, Natural products, Phenazine

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