Phenazines and natural products; novel synthesis of saphenic acid
Research output: Contribution to journal › Journal article › Research › peer-review
The natural product saphenic acid (6-(1-hydroxyethyl)1- phenazinecarboxylic acid) was synthesized from readily accessible starting materials. The desired product was obtained in an overall yield of 22% for four steps with the key steps being formation of a diphenylamine, followed by cyclization under alkaline and reducing conditions. Assignments of 1H NMR spectra were achieved by homo- and heteronuclear 1D and 2D correlations. Double pulsed field gradient spin-echo one-dimensional NOESY proved especially valuable for assignment of aromatic protons.
|Number of pages||4|
|Publication status||Published - 1 Jan 1999|
- Antibiotics, DPFGSE-NOE, Heterocycles, Natural products, Phenazine