Phenazines and natural products; novel synthesis of saphenic acid

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Phenazines and natural products; novel synthesis of saphenic acid. / Petersen, Lars; Jensen, Knud J.; Nielsen, John.

In: Synthesis, No. 10, 01.01.1999, p. 1763-1766.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Petersen, L, Jensen, KJ & Nielsen, J 1999, 'Phenazines and natural products; novel synthesis of saphenic acid', Synthesis, no. 10, pp. 1763-1766. <http://www.scopus.com/inward/record.url?scp=0032877132&partnerID=8YFLogxK>

APA

Petersen, L., Jensen, K. J., & Nielsen, J. (1999). Phenazines and natural products; novel synthesis of saphenic acid. Synthesis, (10), 1763-1766. http://www.scopus.com/inward/record.url?scp=0032877132&partnerID=8YFLogxK

Vancouver

Petersen L, Jensen KJ, Nielsen J. Phenazines and natural products; novel synthesis of saphenic acid. Synthesis. 1999 Jan 1;(10):1763-1766.

Author

Petersen, Lars ; Jensen, Knud J. ; Nielsen, John. / Phenazines and natural products; novel synthesis of saphenic acid. In: Synthesis. 1999 ; No. 10. pp. 1763-1766.

Bibtex

@article{038690deccb048908642106c86dac4a6,
title = "Phenazines and natural products; novel synthesis of saphenic acid",
abstract = "The natural product saphenic acid (6-(1-hydroxyethyl)1- phenazinecarboxylic acid) was synthesized from readily accessible starting materials. The desired product was obtained in an overall yield of 22% for four steps with the key steps being formation of a diphenylamine, followed by cyclization under alkaline and reducing conditions. Assignments of 1H NMR spectra were achieved by homo- and heteronuclear 1D and 2D correlations. Double pulsed field gradient spin-echo one-dimensional NOESY proved especially valuable for assignment of aromatic protons.",
keywords = "Antibiotics, DPFGSE-NOE, Heterocycles, Natural products, Phenazine",
author = "Lars Petersen and Jensen, {Knud J.} and John Nielsen",
year = "1999",
month = jan,
day = "1",
language = "English",
pages = "1763--1766",
journal = "Synthesis",
issn = "0039-7881",
publisher = "GeorgThieme Verlag",
number = "10",

}

RIS

TY - JOUR

T1 - Phenazines and natural products; novel synthesis of saphenic acid

AU - Petersen, Lars

AU - Jensen, Knud J.

AU - Nielsen, John

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The natural product saphenic acid (6-(1-hydroxyethyl)1- phenazinecarboxylic acid) was synthesized from readily accessible starting materials. The desired product was obtained in an overall yield of 22% for four steps with the key steps being formation of a diphenylamine, followed by cyclization under alkaline and reducing conditions. Assignments of 1H NMR spectra were achieved by homo- and heteronuclear 1D and 2D correlations. Double pulsed field gradient spin-echo one-dimensional NOESY proved especially valuable for assignment of aromatic protons.

AB - The natural product saphenic acid (6-(1-hydroxyethyl)1- phenazinecarboxylic acid) was synthesized from readily accessible starting materials. The desired product was obtained in an overall yield of 22% for four steps with the key steps being formation of a diphenylamine, followed by cyclization under alkaline and reducing conditions. Assignments of 1H NMR spectra were achieved by homo- and heteronuclear 1D and 2D correlations. Double pulsed field gradient spin-echo one-dimensional NOESY proved especially valuable for assignment of aromatic protons.

KW - Antibiotics

KW - DPFGSE-NOE

KW - Heterocycles

KW - Natural products

KW - Phenazine

M3 - Journal article

AN - SCOPUS:0032877132

SP - 1763

EP - 1766

JO - Synthesis

JF - Synthesis

SN - 0039-7881

IS - 10

ER -

ID: 131118581