Pathophysiology and management of diabetic gastroenteropathy
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Pathophysiology and management of diabetic gastroenteropathy. / Meldgaard, Theresa; Keller, Jutta; Olesen, Anne Estrup; Olesen, Søren Schou; Krogh, Klaus; Borre, Mette; Farmer, Adam; Brock, Birgitte; Brock, Christina; Drewes, Asbjørn Mohr.
In: Therapeutic Advances in Gastroenterology, Vol. 12, 06.2019, p. 1-17.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Pathophysiology and management of diabetic gastroenteropathy
AU - Meldgaard, Theresa
AU - Keller, Jutta
AU - Olesen, Anne Estrup
AU - Olesen, Søren Schou
AU - Krogh, Klaus
AU - Borre, Mette
AU - Farmer, Adam
AU - Brock, Birgitte
AU - Brock, Christina
AU - Drewes, Asbjørn Mohr
PY - 2019/6
Y1 - 2019/6
N2 - Polyneuropathy is a common complication to diabetes. Neuropathies within the enteric nervous system are associated with gastroenteropathy and marked symptoms that severely reduce quality of life. Symptoms are pleomorphic but include nausea, vomiting, dysphagia, dyspepsia, pain, bloating, diarrhoea, constipation and faecal incontinence. The aims of this review are fourfold. First, to provide a summary of the pathophysiology underlying diabetic gastroenteropathy. Secondly to give an overview of the diagnostic methods. Thirdly, to provide clinicians with a focussed overview of current and future methods for pharmacological and nonpharmacological treatment modalities. Pharmacological management is categorised according to symptoms arising from the upper or lower gut as well as sensory dysfunctions. Dietary management is central to improvement of symptoms and is discussed in detail, and neuromodulatory treatment modalities and other emerging management strategies for diabetic gastroenteropathy are discussed. Finally, we propose a diagnostic/investigation algorithm that can be used to support multidisciplinary management.
AB - Polyneuropathy is a common complication to diabetes. Neuropathies within the enteric nervous system are associated with gastroenteropathy and marked symptoms that severely reduce quality of life. Symptoms are pleomorphic but include nausea, vomiting, dysphagia, dyspepsia, pain, bloating, diarrhoea, constipation and faecal incontinence. The aims of this review are fourfold. First, to provide a summary of the pathophysiology underlying diabetic gastroenteropathy. Secondly to give an overview of the diagnostic methods. Thirdly, to provide clinicians with a focussed overview of current and future methods for pharmacological and nonpharmacological treatment modalities. Pharmacological management is categorised according to symptoms arising from the upper or lower gut as well as sensory dysfunctions. Dietary management is central to improvement of symptoms and is discussed in detail, and neuromodulatory treatment modalities and other emerging management strategies for diabetic gastroenteropathy are discussed. Finally, we propose a diagnostic/investigation algorithm that can be used to support multidisciplinary management.
KW - complications
KW - diabetes mellitus
KW - diabetic neuropathies
KW - enteric nervous system
KW - enteropathy
KW - gastrointestinal motility
KW - gastrointestinal transit
KW - pharmacology
U2 - 10.1177/1756284819852047
DO - 10.1177/1756284819852047
M3 - Review
C2 - 31244895
AN - SCOPUS:85067631490
VL - 12
SP - 1
EP - 17
JO - Therapeutic Advances in Gastroenterology
JF - Therapeutic Advances in Gastroenterology
SN - 1756-283X
ER -
ID: 241104014