Omega-3 fatty acid nanocarriers: Characterization and potential applications

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Lyotropic non-lamellar liquid crystalline (LLC) nano-self-assemblies (including cubosomes and hexosomes) are attractive versatile platforms for the encapsulation and delivery of drugs and nutritional molecules. This is due to their unique structural features and architectural arrangements that afford loading of small molecules and macromolecules having different physicochemical properties with high efficiency. Considering the reported health-promoting effects of long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and their precursors ω-3 PUFA monoacylglycerols; here, we focus on physicochemical and biological properties of a new family of non-lamellar LLC nanoparticles assembled either from binary mixtures of phosphatidylglycerol and three types of ω-3 PUFAs, or from single ω-3 PUFA monoacylglycerols. We discuss recent progress in understanding their complexity, pH sensitivity, and structural tunability, as well as highlight their potential applications in health and medicine.

Original languageEnglish
Article number101728
JournalCurrent Opinion in Colloid and Interface Science
Number of pages13
Publication statusPublished - 2023

Bibliographical note

Funding Information:
A.Y. acknowledges support by the Danish Council for Independent Research – Technology and Production Sciences ; references DFF-7017-00065 and 1 335-00150b . A.Y. further acknowledges financial support by Novo Nordisk Foundation (Grant number NNF22OC0079752 ) and the Danish Natural Sciences Research Council for SAXS experiments (DanScatt). S. G. and H. J. postdoctoral and PhD studies, respectively, are financed by the Higher Education Commission of Pakistan (HEC) . G. D. K. is awarded 2219 postdoctoral grant (number 1059B192203132) by the Scientific and Technological Research Council of Turkey (TUBITAK).

Publisher Copyright:
© 2023 The Author(s)

    Research areas

  • Cubosomes, Hexosomes, Inverse non-lamellar lyotropic liquid crystalline phases, Omega-3 fatty acid monoacylglycerols, Omega-3 fatty acids

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