Klonal hæmatopoiese som mulig risikofaktor for hjerte-kar-sygdom
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Klonal hæmatopoiese som mulig risikofaktor for hjerte-kar-sygdom. / Hansen, Peter Riis.
In: Ugeskrift for Laeger, Vol. 182, No. 34, V04200299, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Klonal hæmatopoiese som mulig risikofaktor for hjerte-kar-sygdom
AU - Hansen, Peter Riis
PY - 2020
Y1 - 2020
N2 - The ageing process is associated with somatic mutations in haematopoietic stem cells, which can lead to clonal haematopoiesis. Recently, clonal haematopoiesis has emerged as a risk factor for cardiovascular disease, and the underlying mechanisms likely involve heightened inflammatory responses in leukocytes derived from mutated clones. This review outlines the concept of clonal haematopoiesis of indeterminate potential and summarises epidemiological and experimental evidence, which support the notion that clonal haematopoiesis-mediated inflammation contributes to cardiovascular disease.
AB - The ageing process is associated with somatic mutations in haematopoietic stem cells, which can lead to clonal haematopoiesis. Recently, clonal haematopoiesis has emerged as a risk factor for cardiovascular disease, and the underlying mechanisms likely involve heightened inflammatory responses in leukocytes derived from mutated clones. This review outlines the concept of clonal haematopoiesis of indeterminate potential and summarises epidemiological and experimental evidence, which support the notion that clonal haematopoiesis-mediated inflammation contributes to cardiovascular disease.
M3 - Tidsskriftartikel
C2 - 32800058
VL - 182
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 34
M1 - V04200299
ER -
ID: 269690839