TY - JOUR

T1 - Ischemic Heart Disease in Chronic Hepatitis B

T2 - A Danish Nationwide Cohort Study

AU - Lau, Frederik Faergemann

AU - Bollerup, Signe

AU - Engsig, Frederik

AU - Krarup, Henrik

AU - Mygind, Lone Hagens

AU - Hansen, Jesper Bach

AU - Madsen, Lone Galmstrup

AU - Thielsen, Peter

AU - Balslev, Ulla

AU - Nielsen, Lars Nørregaard

AU - Barfod, Toke S.

AU - Clausen, Mette Rye

AU - Hobolth, Lise

AU - Laursen, Alex Lund

AU - Tarp, Britta

AU - Roege, Birgit T.

AU - Gerstoft, Jan

AU - Christensen, Peer Brehm

AU - Weis, Nina

N1 - Funding Information: Signe Bollerup has received funding from Manufacturer Vilhelm Pedersen and Wife’s Foundation; Free research funds of University Hospital of Copenhagen, Amager and Hvidovre; Grant in memory of Carpenter Jørgen Holm and wife Elisa B. Hansen (1906–1948); Aase and Ejnar Danielsens Foundation and Scandinavian Society for Antimicrobial Chemotherapy Foundation (SLS-935536).

PY - 2022

Y1 - 2022

N2 - Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population. Study Design and Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model. Results: In total, 6472 persons with CHB and 62,251 age-and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91–1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76–1.21). Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.

AB - Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population. Study Design and Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model. Results: In total, 6472 persons with CHB and 62,251 age-and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91–1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76–1.21). Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.

KW - atherosclerosis

KW - cardiovascular disease

KW - coronary heart disease

KW - general population

KW - hepatitis B virus

KW - ischemic heart disease

KW - viral infection

U2 - 10.2147/CLEP.S361910

DO - 10.2147/CLEP.S361910

M3 - Journal article

C2 - 35879942

AN - SCOPUS:85134373942

VL - 14

SP - 879

EP - 888

JO - Clinical Epidemiology

JF - Clinical Epidemiology

SN - 1179-1349

ER -