Ischemic Heart Disease in Chronic Hepatitis B: A Danish Nationwide Cohort Study

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Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population. Study Design and Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model. Results: In total, 6472 persons with CHB and 62,251 age-and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91–1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76–1.21). Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.

Original languageEnglish
JournalClinical Epidemiology
Volume14
Pages (from-to)879-888
ISSN1179-1349
DOIs
Publication statusPublished - 2022

Bibliographical note

Funding Information:
Signe Bollerup has received funding from Manufacturer Vilhelm Pedersen and Wife’s Foundation; Free research funds of University Hospital of Copenhagen, Amager and Hvidovre; Grant in memory of Carpenter Jørgen Holm and wife Elisa B. Hansen (1906–1948); Aase and Ejnar Danielsens Foundation and Scandinavian Society for Antimicrobial Chemotherapy Foundation (SLS-935536).

    Research areas

  • atherosclerosis, cardiovascular disease, coronary heart disease, general population, hepatitis B virus, ischemic heart disease, viral infection

ID: 326668729