Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long-term administration? Six case histories
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Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long-term administration? Six case histories. / Sjøgren, P; Thunedborg, L P; Christrup, Lona Louring; Hansen, S H; Franks, J.
In: Acta Anaesthesiologica Scandinavica, Vol. 42, No. 9, 10.1998, p. 1070-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long-term administration?
T2 - Six case histories
AU - Sjøgren, P
AU - Thunedborg, L P
AU - Christrup, Lona Louring
AU - Hansen, S H
AU - Franks, J
PY - 1998/10
Y1 - 1998/10
N2 - Recently, clinical reports have suggested a relationship between the occurrence of hyperalgesia, allodynia and/or myoclonus and treatment with high doses of morphine in humans. Although few clinical descriptions of these phenomena are available, experimental work supports the notion that high doses of morphine may play a pathogenetic role in the observed behavioural syndrome.
AB - Recently, clinical reports have suggested a relationship between the occurrence of hyperalgesia, allodynia and/or myoclonus and treatment with high doses of morphine in humans. Although few clinical descriptions of these phenomena are available, experimental work supports the notion that high doses of morphine may play a pathogenetic role in the observed behavioural syndrome.
KW - Aged
KW - Analgesics, Opioid
KW - Female
KW - Glucuronosyltransferase
KW - Humans
KW - Hyperalgesia
KW - Male
KW - Middle Aged
KW - Morphine
KW - Morphine Derivatives
KW - Myoclonus
M3 - Journal article
C2 - 9809090
VL - 42
SP - 1070
EP - 1075
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
SN - 0001-5172
IS - 9
ER -
ID: 46099451