Heterochromatin: an epigenetic point of view in aging

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Heterochromatin : an epigenetic point of view in aging. / Lee, Jong-Hyuk; Kim, Edward W; Croteau, Deborah L; Bohr, Vilhelm A.

In: Experimental & Molecular Medicine, Vol. 52, No. 9, 2020, p. 1466-1474.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Lee, J-H, Kim, EW, Croteau, DL & Bohr, VA 2020, 'Heterochromatin: an epigenetic point of view in aging', Experimental & Molecular Medicine, vol. 52, no. 9, pp. 1466-1474. https://doi.org/10.1038/s12276-020-00497-4

APA

Lee, J-H., Kim, E. W., Croteau, D. L., & Bohr, V. A. (2020). Heterochromatin: an epigenetic point of view in aging. Experimental & Molecular Medicine, 52(9), 1466-1474. https://doi.org/10.1038/s12276-020-00497-4

Vancouver

Lee J-H, Kim EW, Croteau DL, Bohr VA. Heterochromatin: an epigenetic point of view in aging. Experimental & Molecular Medicine. 2020;52(9):1466-1474. https://doi.org/10.1038/s12276-020-00497-4

Author

Lee, Jong-Hyuk ; Kim, Edward W ; Croteau, Deborah L ; Bohr, Vilhelm A. / Heterochromatin : an epigenetic point of view in aging. In: Experimental & Molecular Medicine. 2020 ; Vol. 52, No. 9. pp. 1466-1474.

Bibtex

@article{ab993e2143904dc786a1b3a1d936738e,
title = "Heterochromatin: an epigenetic point of view in aging",
abstract = "Aging is an inevitable process of life. Defined by progressive physiological and functional loss of tissues and organs, aging increases the risk of mortality for the organism. The aging process is affected by various factors, including genetic and epigenetic ones. Here, we review the chromatin-specific epigenetic changes that occur during normal (chronological) aging and in premature aging diseases. Taking advantage of the reversible nature of epigenetic modifications, we will also discuss possible lifespan expansion strategies through epigenetic modulation, which was considered irreversible until recently.",
author = "Jong-Hyuk Lee and Kim, {Edward W} and Croteau, {Deborah L} and Bohr, {Vilhelm A}",
year = "2020",
doi = "10.1038/s12276-020-00497-4",
language = "English",
volume = "52",
pages = "1466--1474",
journal = "Experimental & Molecular Medicine",
issn = "1226-3613",
publisher = "nature publishing group",
number = "9",

}

RIS

TY - JOUR

T1 - Heterochromatin

T2 - an epigenetic point of view in aging

AU - Lee, Jong-Hyuk

AU - Kim, Edward W

AU - Croteau, Deborah L

AU - Bohr, Vilhelm A

PY - 2020

Y1 - 2020

N2 - Aging is an inevitable process of life. Defined by progressive physiological and functional loss of tissues and organs, aging increases the risk of mortality for the organism. The aging process is affected by various factors, including genetic and epigenetic ones. Here, we review the chromatin-specific epigenetic changes that occur during normal (chronological) aging and in premature aging diseases. Taking advantage of the reversible nature of epigenetic modifications, we will also discuss possible lifespan expansion strategies through epigenetic modulation, which was considered irreversible until recently.

AB - Aging is an inevitable process of life. Defined by progressive physiological and functional loss of tissues and organs, aging increases the risk of mortality for the organism. The aging process is affected by various factors, including genetic and epigenetic ones. Here, we review the chromatin-specific epigenetic changes that occur during normal (chronological) aging and in premature aging diseases. Taking advantage of the reversible nature of epigenetic modifications, we will also discuss possible lifespan expansion strategies through epigenetic modulation, which was considered irreversible until recently.

U2 - 10.1038/s12276-020-00497-4

DO - 10.1038/s12276-020-00497-4

M3 - Review

C2 - 32887933

VL - 52

SP - 1466

EP - 1474

JO - Experimental & Molecular Medicine

JF - Experimental & Molecular Medicine

SN - 1226-3613

IS - 9

ER -

ID: 257865908