TY - JOUR

T1 - Graft-derived anti-HPA-2b production after allogeneic bone-marrow transplantation

AU - Taaning, E

AU - Jacobsen, N

AU - Morling, N

N1 - Keywords: Antigens, Human Platelet; Blood Platelets; Bone Marrow Transplantation; Humans; Immunoglobulin G; Leukemia, Myeloid, Acute; Male; Middle Aged; Platelet Count; Platelet Transfusion; Transplantation, Homologous

PY - 1994

Y1 - 1994

N2 - We report on a male who received a bone-marrow allograft from his HLA identical sister for acute myelogenous leukaemia. After transplantation, the patient suffered from refractoriness to the transfusions of HLA-matched platelets and a strong platelet-specific antibody, anti-HPA-2b, of IgG1 subclass was demonstrated in the patient's serum. In the serum of the bone-marrow donor a weak IgG1 anti-HPA-2b was demonstrated. IgG allotyping of the patient and donor showed identical results. We could not determine the origin of the anti-HPA-2b, although we hypothesize that the anti-HPA-2b was produced by immunocompetent donor lymphocytes infused with the suspension of bone-marrow cells.

AB - We report on a male who received a bone-marrow allograft from his HLA identical sister for acute myelogenous leukaemia. After transplantation, the patient suffered from refractoriness to the transfusions of HLA-matched platelets and a strong platelet-specific antibody, anti-HPA-2b, of IgG1 subclass was demonstrated in the patient's serum. In the serum of the bone-marrow donor a weak IgG1 anti-HPA-2b was demonstrated. IgG allotyping of the patient and donor showed identical results. We could not determine the origin of the anti-HPA-2b, although we hypothesize that the anti-HPA-2b was produced by immunocompetent donor lymphocytes infused with the suspension of bone-marrow cells.

M3 - Journal article

C2 - 8043449

VL - 86

SP - 651

EP - 653

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 3

ER -