Graft-derived anti-HPA-2b production after allogeneic bone-marrow transplantation

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We report on a male who received a bone-marrow allograft from his HLA identical sister for acute myelogenous leukaemia. After transplantation, the patient suffered from refractoriness to the transfusions of HLA-matched platelets and a strong platelet-specific antibody, anti-HPA-2b, of IgG1 subclass was demonstrated in the patient's serum. In the serum of the bone-marrow donor a weak IgG1 anti-HPA-2b was demonstrated. IgG allotyping of the patient and donor showed identical results. We could not determine the origin of the anti-HPA-2b, although we hypothesize that the anti-HPA-2b was produced by immunocompetent donor lymphocytes infused with the suspension of bone-marrow cells.
Original languageEnglish
JournalBritish Journal of Haematology
Issue number3
Pages (from-to)651-3
Number of pages2
Publication statusPublished - 1994

Bibliographical note

Keywords: Antigens, Human Platelet; Blood Platelets; Bone Marrow Transplantation; Humans; Immunoglobulin G; Leukemia, Myeloid, Acute; Male; Middle Aged; Platelet Count; Platelet Transfusion; Transplantation, Homologous

ID: 16186154