Gene delivery by electroporation
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Gene delivery by electroporation. / Gehl, Julie.
Drug Delivery: An Integrated Clinical and Engineering Approach. CRC Press, 2017. p. 341-348.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Gene delivery by electroporation
AU - Gehl, Julie
N1 - Publisher Copyright: © 2017 by Taylor & Francis Group, LLC.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - By applying brief electric pulses, it is possible to transfer molecules into cells and tissues. The use of electroporation for delivery of chemotherapy is now quite widely used and in further development. Electrochemotherapy is in routine use for cutaneous tumors [1] in more than 100 cancer centers, and several thousand patients have been treated. Response rates are high and side effects limited [2-8]. An important perspective about the success of electrochemotherapy is that electroporation equipment approved for clinical use is now available in many hospitals, allowing its use for gene therapy.
AB - By applying brief electric pulses, it is possible to transfer molecules into cells and tissues. The use of electroporation for delivery of chemotherapy is now quite widely used and in further development. Electrochemotherapy is in routine use for cutaneous tumors [1] in more than 100 cancer centers, and several thousand patients have been treated. Response rates are high and side effects limited [2-8]. An important perspective about the success of electrochemotherapy is that electroporation equipment approved for clinical use is now available in many hospitals, allowing its use for gene therapy.
UR - http://www.scopus.com/inward/record.url?scp=85054276123&partnerID=8YFLogxK
U2 - 10.1201/9781315117584
DO - 10.1201/9781315117584
M3 - Book chapter
AN - SCOPUS:85054276123
SN - 9781466565944
SP - 341
EP - 348
BT - Drug Delivery
PB - CRC Press
ER -
ID: 318949036