Exercise training lowers arterial blood pressure independently of Pannexin 1 in men with essential hypertension
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Exercise training lowers arterial blood pressure independently of Pannexin 1 in men with essential hypertension. / Møller, Sophie; Hansen, Camilla Collin; Ehlers, Thomas Svare; Tamariz-Ellemann, Andrea; Tolborg, Sarah Á Rògvi; Kurell, Melanie Emmonds; Pérez-Gómez, Jorge; Patrzalek, Simon Schultz; Maulitz, Christine; Hellsten, Ylva; Gliemann, Lasse.
In: Medicine and Science in Sports and Exercise, Vol. 54, No. 9, 2022, p. 1417-1427.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Exercise training lowers arterial blood pressure independently of Pannexin 1 in men with essential hypertension
AU - Møller, Sophie
AU - Hansen, Camilla Collin
AU - Ehlers, Thomas Svare
AU - Tamariz-Ellemann, Andrea
AU - Tolborg, Sarah Á Rògvi
AU - Kurell, Melanie Emmonds
AU - Pérez-Gómez, Jorge
AU - Patrzalek, Simon Schultz
AU - Maulitz, Christine
AU - Hellsten, Ylva
AU - Gliemann, Lasse
N1 - Copyright © 2022 by the American College of Sports Medicine.
PY - 2022
Y1 - 2022
N2 - Introduction: Regular exercise training reduces arterial blood pressure but the underlying mechanisms are unclear. Here, we evaluated the potential involvement of Pannexin 1, an ATP releasing channel, in the blood pressure-reducing effect of training.Methods: Middle-aged men; 13 normotensive and 14 non-medicated stage 1 hypertensive, completed 8 weeks of intensive aerobic cycle training. Before and after training, blood pressure and changes in leg vascular conductance, induced by femoral arterial infusion of tyramine (induces endogenous noradrenaline release), acetylcholine or sodium nitroprusside were measured during control conditions and after acute Pannexin 1 inhibition by probenecid. A skeletal muscle biopsy was obtained from the thigh, pre- and post-training.Results: Exercise training reduced mean systolic and diastolic blood pressure by ~5 (P = 0.013) and 5 mmHg (P < 0.001), respectively, in the hypertensive group only. The reduction in blood pressure was not related to changes in Pannexin-1 function since mean arterial blood pressure and tyramine-induced vasoconstriction remain unaltered by Pannexin 1 inhibition after training in both groups. After training, Pannexin 1 inhibition enhanced leg vascular conductance in the normo- and hypertensive groups at baseline (41.5%, P = 0.0036 and 37.7%, P = 0.024, respectively) and in response to sodium nitroprusside infusion (275%, P = 0.038 and 188%, P = 0.038, respectively). Training did not alter the Pannexin 1 protein expression in skeletal muscle. Training enhanced the vasodilator response to acetylcholine infusion, and increased the expression of microvascular function-relevant proteins.Conclusions: The exercise training-induced lowering of arterial blood pressure in non-medicated hypertensive men, does not involve an altered function of Pannexin 1.
AB - Introduction: Regular exercise training reduces arterial blood pressure but the underlying mechanisms are unclear. Here, we evaluated the potential involvement of Pannexin 1, an ATP releasing channel, in the blood pressure-reducing effect of training.Methods: Middle-aged men; 13 normotensive and 14 non-medicated stage 1 hypertensive, completed 8 weeks of intensive aerobic cycle training. Before and after training, blood pressure and changes in leg vascular conductance, induced by femoral arterial infusion of tyramine (induces endogenous noradrenaline release), acetylcholine or sodium nitroprusside were measured during control conditions and after acute Pannexin 1 inhibition by probenecid. A skeletal muscle biopsy was obtained from the thigh, pre- and post-training.Results: Exercise training reduced mean systolic and diastolic blood pressure by ~5 (P = 0.013) and 5 mmHg (P < 0.001), respectively, in the hypertensive group only. The reduction in blood pressure was not related to changes in Pannexin-1 function since mean arterial blood pressure and tyramine-induced vasoconstriction remain unaltered by Pannexin 1 inhibition after training in both groups. After training, Pannexin 1 inhibition enhanced leg vascular conductance in the normo- and hypertensive groups at baseline (41.5%, P = 0.0036 and 37.7%, P = 0.024, respectively) and in response to sodium nitroprusside infusion (275%, P = 0.038 and 188%, P = 0.038, respectively). Training did not alter the Pannexin 1 protein expression in skeletal muscle. Training enhanced the vasodilator response to acetylcholine infusion, and increased the expression of microvascular function-relevant proteins.Conclusions: The exercise training-induced lowering of arterial blood pressure in non-medicated hypertensive men, does not involve an altered function of Pannexin 1.
KW - Faculty of Science
KW - High blood pressure
KW - Pannexin 1
KW - Physical activity
KW - Probenecid
KW - Vascular conductance
U2 - 10.1249/MSS.0000000000002936
DO - 10.1249/MSS.0000000000002936
M3 - Journal article
C2 - 35420578
VL - 54
SP - 1417
EP - 1427
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
SN - 0195-9131
IS - 9
ER -
ID: 303441162