Exercise training lowers arterial blood pressure independently of Pannexin 1 in men with essential hypertension
Research output: Contribution to journal › Journal article › Research › peer-review
- Moller et al_Medicine & Science in Sports & Exercise_2022_e2936_(Accepted manuscript)
Accepted author manuscript, 2.63 MB, PDF document
Introduction: Regular exercise training reduces arterial blood pressure but the underlying mechanisms are unclear. Here, we evaluated the potential involvement of Pannexin 1, an ATP releasing channel, in the blood pressure-reducing effect of training.
Methods: Middle-aged men; 13 normotensive and 14 non-medicated stage 1 hypertensive, completed 8 weeks of intensive aerobic cycle training. Before and after training, blood pressure and changes in leg vascular conductance, induced by femoral arterial infusion of tyramine (induces endogenous noradrenaline release), acetylcholine or sodium nitroprusside were measured during control conditions and after acute Pannexin 1 inhibition by probenecid. A skeletal muscle biopsy was obtained from the thigh, pre- and post-training.
Results: Exercise training reduced mean systolic and diastolic blood pressure by ~5 (P = 0.013) and 5 mmHg (P < 0.001), respectively, in the hypertensive group only. The reduction in blood pressure was not related to changes in Pannexin-1 function since mean arterial blood pressure and tyramine-induced vasoconstriction remain unaltered by Pannexin 1 inhibition after training in both groups. After training, Pannexin 1 inhibition enhanced leg vascular conductance in the normo- and hypertensive groups at baseline (41.5%, P = 0.0036 and 37.7%, P = 0.024, respectively) and in response to sodium nitroprusside infusion (275%, P = 0.038 and 188%, P = 0.038, respectively). Training did not alter the Pannexin 1 protein expression in skeletal muscle. Training enhanced the vasodilator response to acetylcholine infusion, and increased the expression of microvascular function-relevant proteins.
Conclusions: The exercise training-induced lowering of arterial blood pressure in non-medicated hypertensive men, does not involve an altered function of Pannexin 1.
|Journal||Medicine and Science in Sports and Exercise|
|Number of pages||11|
|Publication status||Published - 2022|
Copyright © 2022 by the American College of Sports Medicine.
- Faculty of Science - High blood pressure, Pannexin 1, Physical activity, Probenecid, Vascular conductance
Number of downloads are based on statistics from Google Scholar and www.ku.dk