Cytoplasmic mRNPs revisited: Singletons and condensates

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Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.

Original languageEnglish
Article number2000097
JournalBioEssays
Volume42
Issue number12
Number of pages13
ISSN0265-9247
DOIs
Publication statusPublished - 2020

    Research areas

  • biomolecular condensates, mRNA transport, mRNP granules, P&#8208, bodies, RNA regulons, singletons, stress granules, CAP-BINDING PROTEIN, TRANSLATION INITIATION COMPLEX, MESSENGER-RNA TRANSLATION, CLOSED-LOOP MODEL, P-BODIES, STRESS GRANULES, PROCESSING BODIES, EMERGING ROLES, REVEALS, ORGANIZATION

ID: 251734263