Cytoplasmic mRNPs revisited: Singletons and condensates
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- Cytoplasmic mRNPs revisited: Singletons and condensates
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Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.
|Number of pages||13|
|Publication status||Published - 2020|
- biomolecular condensates, mRNA transport, mRNP granules, P‐, bodies, RNA regulons, singletons, stress granules, CAP-BINDING PROTEIN, TRANSLATION INITIATION COMPLEX, MESSENGER-RNA TRANSLATION, CLOSED-LOOP MODEL, P-BODIES, STRESS GRANULES, PROCESSING BODIES, EMERGING ROLES, REVEALS, ORGANIZATION