Cytoplasmic mRNPs revisited: Singletons and condensates

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Cytoplasmic mRNPs revisited : Singletons and condensates. / Mateu-Regue, Angels; Nielsen, Finn Cilius; Christiansen, Jan.

In: BioEssays, Vol. 42, No. 12, 2000097, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mateu-Regue, A, Nielsen, FC & Christiansen, J 2020, 'Cytoplasmic mRNPs revisited: Singletons and condensates', BioEssays, vol. 42, no. 12, 2000097. https://doi.org/10.1002/bies.202000097

APA

Mateu-Regue, A., Nielsen, F. C., & Christiansen, J. (2020). Cytoplasmic mRNPs revisited: Singletons and condensates. BioEssays, 42(12), [2000097]. https://doi.org/10.1002/bies.202000097

Vancouver

Mateu-Regue A, Nielsen FC, Christiansen J. Cytoplasmic mRNPs revisited: Singletons and condensates. BioEssays. 2020;42(12). 2000097. https://doi.org/10.1002/bies.202000097

Author

Mateu-Regue, Angels ; Nielsen, Finn Cilius ; Christiansen, Jan. / Cytoplasmic mRNPs revisited : Singletons and condensates. In: BioEssays. 2020 ; Vol. 42, No. 12.

Bibtex

@article{d13edafc998d47e99837803a8cdf5c8b,
title = "Cytoplasmic mRNPs revisited: Singletons and condensates",
abstract = "Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.",
keywords = "biomolecular condensates, mRNA transport, mRNP granules, P&#8208, bodies, RNA regulons, singletons, stress granules, CAP-BINDING PROTEIN, TRANSLATION INITIATION COMPLEX, MESSENGER-RNA TRANSLATION, CLOSED-LOOP MODEL, P-BODIES, STRESS GRANULES, PROCESSING BODIES, EMERGING ROLES, REVEALS, ORGANIZATION",
author = "Angels Mateu-Regue and Nielsen, {Finn Cilius} and Jan Christiansen",
year = "2020",
doi = "10.1002/bies.202000097",
language = "English",
volume = "42",
journal = "BioEssays",
issn = "0265-9247",
publisher = "Wiley",
number = "12",

}

RIS

TY - JOUR

T1 - Cytoplasmic mRNPs revisited

T2 - Singletons and condensates

AU - Mateu-Regue, Angels

AU - Nielsen, Finn Cilius

AU - Christiansen, Jan

PY - 2020

Y1 - 2020

N2 - Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.

AB - Cytoplasmic messenger ribonucleoprotein particles (mRNPs) represent the cellular transcriptome, and recent data have challenged our current understanding of their architecture, transport, and complexity before translation. Pre-translational mRNPs are composed of a single transcript, whereas P-bodies and stress granules are condensates. Both pre-translational mRNPs and actively translating mRNPs seem to adopt a linear rather than a closed-loop configuration. Moreover, assembly of pre-translational mRNPs in physical RNA regulons is an unlikely event, and co-regulated translation may occur locally following extracellular cues. We envisage a stochastic mRNP transport mechanism where translational repression of single mRNPs-in combination with microtubule-mediated cytoplasmic streaming and docking events-are prerequisites for local translation, rather than direct transport.

KW - biomolecular condensates

KW - mRNA transport

KW - mRNP granules

KW - P&#8208

KW - bodies

KW - RNA regulons

KW - singletons

KW - stress granules

KW - CAP-BINDING PROTEIN

KW - TRANSLATION INITIATION COMPLEX

KW - MESSENGER-RNA TRANSLATION

KW - CLOSED-LOOP MODEL

KW - P-BODIES

KW - STRESS GRANULES

KW - PROCESSING BODIES

KW - EMERGING ROLES

KW - REVEALS

KW - ORGANIZATION

U2 - 10.1002/bies.202000097

DO - 10.1002/bies.202000097

M3 - Journal article

C2 - 33145808

VL - 42

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 12

M1 - 2000097

ER -

ID: 251734263