Circulating intercellular adhesion molecule-1 (ICAM-1) as an early and sensitive marker for virus-induced T cell activation
Research output: Contribution to journal › Journal article › Research › peer-review
The effect of systemic virus infection on the level of circulating ICAM-1 (cICAM-1) in serum, and the role of virus-activated T cells in this context, were studied using the murine lymphocytic choriomeningitis virus infection as primary model system. A marked virus-induced elevation in cICAM-1 in serum was revealed, the presence of which coincided with the phase of virus-induced T cell activation. However, high levels of cICAM-1 in serum were observed well before maximal T cell activation could be demonstrated. No increase in cICAM-1 was observed in the serum of infected T cell-deficient nude mice, clearly demonstrating that T cells were mandatory. Analysis of MHC class I and MHC class II-deficient mice revealed that either CD4+ or CD8+ T cells alone are sufficient, despite a markedly reduced inflammatory exudate in the former animals. These results indicate that virus-activated T cells induce shedding of ICAM-1 into the circulation, and this parameter may be used as an early and sensitive marker for immune activation.
Original language | English |
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Journal | Clinical and Experimental Immunology |
Volume | 102 |
Issue number | 2 |
Pages (from-to) | 268-73 |
Number of pages | 5 |
ISSN | 0009-9104 |
Publication status | Published - 1995 |
Bibliographical note
Keywords: Animals; Biological Markers; Intercellular Adhesion Molecule-1; Lymphocyte Activation; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred BALB C; Mice, Nude; Solubility; T-Lymphocytes; Time Factors; Vesicular stomatitis Indiana virus
ID: 9639805