Ambient and at-the-ear occupational noise exposure and serum lipid levels
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Ambient and at-the-ear occupational noise exposure and serum lipid levels. / Arlien-Søborg, Mai C; Schmedes, Astrid S; Stokholm, Z A; Grynderup, M B; Bonde, J P; Jensen, C S; Hansen, Å M; Frederiksen, T W; Kristiansen, J; Christensen, K L; Vestergaard, J M; Lund, S P; Kolstad, H A.
In: International Archives of Occupational and Environmental Health, Vol. 89, No. 7, 10.2016, p. 1087-1093.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Ambient and at-the-ear occupational noise exposure and serum lipid levels
AU - Arlien-Søborg, Mai C
AU - Schmedes, Astrid S
AU - Stokholm, Z A
AU - Grynderup, M B
AU - Bonde, J P
AU - Jensen, C S
AU - Hansen, Å M
AU - Frederiksen, T W
AU - Kristiansen, J
AU - Christensen, K L
AU - Vestergaard, J M
AU - Lund, S P
AU - Kolstad, H A
PY - 2016/10
Y1 - 2016/10
N2 - OBJECTIVES: Occupational and residential noise exposure has been related to increased risk of cardiovascular disease. Alteration of serum lipid levels has been proposed as a possible causal pathway. The objective of this study was to investigate the relation between ambient and at-the-ear occupational noise exposure and serum levels of total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, and triglycerides when accounting for well-established predictors of lipid levels.METHODS: This cross-sectional study included 424 industrial workers and 84 financial workers to obtain contrast in noise exposure levels. They provided a serum sample and wore portable dosimeters that every 5-s recorded ambient noise exposure levels during a 24-h period. We extracted measurements obtained during work and calculated the full-shift mean ambient noise level. For 331 workers who kept a diary on the use of a hearing protection device (HPD), we subtracted 10 dB from every noise recording obtained during HPD use and estimated the mean full-shift noise exposure level at the ear.RESULTS: Mean ambient noise level was 79.9 dB (A) [range 55.0-98.9] and the mean estimated level at the ear 77.8 dB (A) [range 55.0-94.2]. Ambient and at-the-ear noise levels were strongly associated with increasing levels of triglycerides, cholesterol-HDL ratio, and decreasing levels of HDL-cholesterol, but only in unadjusted analyses that did not account for HPD use and other risk factors.CONCLUSION: No associations between ambient or at-the-ear occupational noise exposure and serum lipid levels were observed. This indicates that a causal pathway between occupational and residential noise exposure and cardiovascular disease does not include alteration of lipid levels.
AB - OBJECTIVES: Occupational and residential noise exposure has been related to increased risk of cardiovascular disease. Alteration of serum lipid levels has been proposed as a possible causal pathway. The objective of this study was to investigate the relation between ambient and at-the-ear occupational noise exposure and serum levels of total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, and triglycerides when accounting for well-established predictors of lipid levels.METHODS: This cross-sectional study included 424 industrial workers and 84 financial workers to obtain contrast in noise exposure levels. They provided a serum sample and wore portable dosimeters that every 5-s recorded ambient noise exposure levels during a 24-h period. We extracted measurements obtained during work and calculated the full-shift mean ambient noise level. For 331 workers who kept a diary on the use of a hearing protection device (HPD), we subtracted 10 dB from every noise recording obtained during HPD use and estimated the mean full-shift noise exposure level at the ear.RESULTS: Mean ambient noise level was 79.9 dB (A) [range 55.0-98.9] and the mean estimated level at the ear 77.8 dB (A) [range 55.0-94.2]. Ambient and at-the-ear noise levels were strongly associated with increasing levels of triglycerides, cholesterol-HDL ratio, and decreasing levels of HDL-cholesterol, but only in unadjusted analyses that did not account for HPD use and other risk factors.CONCLUSION: No associations between ambient or at-the-ear occupational noise exposure and serum lipid levels were observed. This indicates that a causal pathway between occupational and residential noise exposure and cardiovascular disease does not include alteration of lipid levels.
U2 - 10.1007/s00420-016-1145-3
DO - 10.1007/s00420-016-1145-3
M3 - Journal article
C2 - 27319006
VL - 89
SP - 1087
EP - 1093
JO - International Archives of Occupational and Environmental Health
JF - International Archives of Occupational and Environmental Health
SN - 0340-0131
IS - 7
ER -
ID: 164585497