TY - JOUR

T1 - Advancing tools for human early lifecourse exposome research and translation (ATHLETE)

AU - Vrijheid, Martine

AU - Basagaña, Xavier

AU - Gonzalez, Juan R.

AU - Jaddoe, Vincent W.V.

AU - Jensen, Genon

AU - Keun, Hector C.

AU - McEachan, Rosemary R.C.

AU - Porcel, Joana

AU - Siroux, Valerie

AU - Swertz, Morris A.

AU - Thomsen, Cathrine

AU - Aasvang, Gunn Marit

AU - Andrušaitytė, Sandra

AU - Angeli, Karine

AU - Avraam, Demetris

AU - Ballester, Ferran

AU - Burton, Paul

AU - Bustamante, Mariona

AU - Casas, Maribel

AU - Chatzi, Leda

AU - Chevrier, Cécile

AU - Cingotti, Natacha

AU - Conti, David

AU - Crépet, Amélie

AU - Dadvand, Payam

AU - Duijts, Liesbeth

AU - van Enckevort, Esther

AU - Esplugues, Ana

AU - Fossati, Serena

AU - Garlantezec, Ronan

AU - Roig, María Dolores Gómez

AU - Grazuleviciene, Regina

AU - Gützkow, Kristine B.

AU - Guxens, Mònica

AU - Haakma, Sido

AU - Hessel, Ellen V.S.

AU - Hoyles, Lesley

AU - Hyde, Eleanor

AU - Klanova, Jana

AU - van Klaveren, Jacob D.

AU - Kortenkamp, Andreas

AU - Le Brusquet, Laurent

AU - Leenen, Ivonne

AU - Lertxundi, Aitana

AU - Lertxundi, Nerea

AU - Lionis, Christos

AU - Llop, Sabrina

AU - Lopez-Espinosa, Maria Jose

AU - Lyon-Caen, Sarah

AU - Maitre, Lea

AU - Mason, Dan

AU - Mathy, Sandrine

AU - Mazarico, Edurne

AU - Nawrot, Tim

AU - Pedersen, Marie

AU - Ortiz, Rodney

AU - Perelló, Josep

AU - Pérez-Cruz, Míriam

AU - Philippat, Claire

AU - Piler, Pavel

AU - Pizzi, Costanza

AU - Quentin, Joane

AU - Richiardi, Lorenzo

AU - Rodriguez, Adrian

AU - Roumeliotaki, Theano

AU - Capote, José Manuel Sabin

AU - Santiago, Leonardo

AU - Santos, Susana

AU - Siskos, Alexandros P.

AU - Strandberg-Larsen, Katrine

AU - Stratakis, Nikos

AU - Sunyer, Jordi

AU - Tenenhaus, Arthur

AU - Vafeiadi, Marina

AU - Wilson, Rebecca C.

AU - Wright, John

AU - Yang, Tiffany

AU - Slama, Remy

N1 - Publisher Copyright: Copyright © 2021 The Authors.

PY - 2021

Y1 - 2021

N2 - Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE's results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.

AB - Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE's results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.

KW - Adolescent health

KW - Child health

KW - Early life

KW - Exposome

KW - Exposure assessment

U2 - 10.1097/EE9.0000000000000166

DO - 10.1097/EE9.0000000000000166

M3 - Review

C2 - 34934888

AN - SCOPUS:85124242578

VL - 5

JO - Environmental Epidemiology

JF - Environmental Epidemiology

SN - 2474-7882

IS - 5

M1 - E166

ER -