Advancing tools for human early lifecourse exposome research and translation (ATHLETE)

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  • Martine Vrijheid
  • Xavier Basagaña
  • Juan R. Gonzalez
  • Vincent W.V. Jaddoe
  • Genon Jensen
  • Hector C. Keun
  • Rosemary R.C. McEachan
  • Joana Porcel
  • Valerie Siroux
  • Morris A. Swertz
  • Cathrine Thomsen
  • Gunn Marit Aasvang
  • Sandra Andrušaitytė
  • Karine Angeli
  • Demetris Avraam
  • Ferran Ballester
  • Paul Burton
  • Mariona Bustamante
  • Maribel Casas
  • Leda Chatzi
  • Cécile Chevrier
  • Natacha Cingotti
  • David Conti
  • Amélie Crépet
  • Payam Dadvand
  • Liesbeth Duijts
  • Esther van Enckevort
  • Ana Esplugues
  • Serena Fossati
  • Ronan Garlantezec
  • María Dolores Gómez Roig
  • Regina Grazuleviciene
  • Kristine B. Gützkow
  • Mònica Guxens
  • Sido Haakma
  • Ellen V.S. Hessel
  • Lesley Hoyles
  • Eleanor Hyde
  • Jana Klanova
  • Jacob D. van Klaveren
  • Andreas Kortenkamp
  • Laurent Le Brusquet
  • Ivonne Leenen
  • Aitana Lertxundi
  • Nerea Lertxundi
  • Christos Lionis
  • Sabrina Llop
  • Maria Jose Lopez-Espinosa
  • Sarah Lyon-Caen
  • Lea Maitre
  • Dan Mason
  • Sandrine Mathy
  • Edurne Mazarico
  • Tim Nawrot
  • Rodney Ortiz
  • Josep Perelló
  • Míriam Pérez-Cruz
  • Claire Philippat
  • Pavel Piler
  • Costanza Pizzi
  • Joane Quentin
  • Lorenzo Richiardi
  • Adrian Rodriguez
  • Theano Roumeliotaki
  • José Manuel Sabin Capote
  • Leonardo Santiago
  • Susana Santos
  • Alexandros P. Siskos
  • Nikos Stratakis
  • Jordi Sunyer
  • Arthur Tenenhaus
  • Marina Vafeiadi
  • Rebecca C. Wilson
  • John Wright
  • Tiffany Yang
  • Remy Slama

Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE's results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.

Original languageEnglish
Article numberE166
JournalEnvironmental Epidemiology
Volume5
Issue number5
Number of pages15
ISSN2474-7882
DOIs
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
Copyright © 2021 The Authors.

    Research areas

  • Adolescent health, Child health, Early life, Exposome, Exposure assessment

ID: 300682235