Acetylation regulates WRN catalytic activities and affects base excision DNA repair
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Acetylation regulates WRN catalytic activities and affects base excision DNA repair. / Muftuoglu, Meltem; Kusumoto, Rika; Speina, Elzbieta; Beck, Gad; Cheng, Wen-Hsing; Bohr, Vilhelm A.
In: P L o S One, Vol. 3, No. 4, 01.2008, p. e1918.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Acetylation regulates WRN catalytic activities and affects base excision DNA repair
AU - Muftuoglu, Meltem
AU - Kusumoto, Rika
AU - Speina, Elzbieta
AU - Beck, Gad
AU - Cheng, Wen-Hsing
AU - Bohr, Vilhelm A
PY - 2008/1
Y1 - 2008/1
N2 - The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription.
AB - The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription.
KW - Aging
KW - Catalysis
KW - Cell Line
KW - DNA
KW - DNA Damage
KW - DNA Repair
KW - Exodeoxyribonucleases
KW - Exonucleases
KW - Hela Cells
KW - Histone Acetyltransferases
KW - Humans
KW - Protein Processing, Post-Translational
KW - Protein Structure, Tertiary
KW - RecQ Helicases
KW - Recombinant Proteins
KW - Transcription, Genetic
U2 - 10.1371/journal.pone.0001918
DO - 10.1371/journal.pone.0001918
M3 - Journal article
C2 - 18398454
VL - 3
SP - e1918
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 4
ER -
ID: 32949176