Ulrik Gether

Ulrik Gether

Head of Department, Professor

ORCID: 0000-0002-0020-3807

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  1. Published

    The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells

    da Silva Pinheiro, P. C., Jansen, A. M., de Wit, H., Tawfik, B., Madsen, Kenneth Lindegaard, Verhage, M., Gether, Ulrik & Sørensen, Jakob Balslev, 6 Aug 2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 32, p. 10688-700 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini

    Vuorenpää, A. E., Jørgensen, T. N., Newman, A. H., Madsen, Kenneth Lindegaard, Scheinin, M. & Gether, Ulrik, 11 Mar 2016, In: Journal of Biological Chemistry. 291, 11, p. 5634-5651 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function

    Vuorenpää, A. E., Ammendrup-Johnsen, I., Jorgensen, T. N. & Gether, Ulrik, Sep 2016, In: Neurochemistry International. 98, p. 103-114

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes

    Vaz, S. H., Jørgensen, T. N., Cristóvão-Ferreira, S., Duflot, S., Ribeiro, J. A., Gether, Ulrik & Sebastião, A. M., 2011, In: Journal of Biological Chemistry. 286, 47, p. 40464-76 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Adaptive aspects of impulsivity and interactions with effects of catecholaminergic agents in the 5-choice serial reaction time task: implications for ADHD

    Toschi, C., Hervig, M. E., Moazen, P., Parker, M. G., Dalley, J. W., Gether, Ulrik & Robbins, T. W., 2021, In: Psychopharmacology. 238, p. 2601–2615 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

    Thorsen, T. S., Madsen, Kenneth Lindegaard, Rebola, N., Rathje, Mette, Anggono, V., Bach, Anders, Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 2010, In: Proceedings of the National Academy of Science of the United States of America. 107, 1, p. 413-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain

    Thorsen, T. S., Madsen, Kenneth Lindegaard, Dyhring, T., Bach, Anders, Peters, D., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 1 Aug 2011, In: Combinatorial Chemistry & High Throughput Screening. 14, 7, p. 590-600 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice

    Thomsen, A. H. R., Jensen, Kathrine Louise, Fitzpatrick, C. M., Dencker, D., Weikop, Pia, Gether, Ulrik & Rickhag, Karl Mattias, Jan 2017, In: European Journal of Neuroscience. 45, 1, p. 121-128

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

    Sørensen, G., Rickhag, Karl Mattias, Leo, D., Lycas, M. D., Ridderstrøm, P. H., Weikop, P., Lilja, J. H., Rifes, P., Herborg, Freja, Woldbye, David Paul Drucker, Wörtwein, Gitta, Gainetdinov, R. R., Fink-Jensen, Anders & Gether, Ulrik, 2021, In: Journal of Biological Chemistry. 297, 6, 101361.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The Scaffold Protein PICK1 as a Target in Chronic Pain

    Sørensen, Andreas Toft, Rombach, Joscha, Gether, Ulrik & Madsen, Kenneth Lindegaard, 2022, In: Cells. 11, 8, 1255.

    Research output: Contribution to journal › Review › Research › peer-review

  11. Published

    The N terminus of monoamine transporters is a lever required for the action of amphetamines

    Sucic, S., Dallinger, S., Zdrazil, B., Weissensteiner, R., Jørgensen, T. N., Holy, M., Kudlacek, O., Seidel, S., Cha, J. H., Gether, Ulrik, Newman, A. H., Ecker, G. F., Freissmuth, M. & Sitte, H. H., 2010, In: Journal of Biological Chemistry. 285, 14, p. 10924-38 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Amphetamine-induced reverse transport of dopamine does not require cytosolic Ca2+

    Støier, J. F., Konomi Pilkati, Ainoa, Apuschkin, Mia, Herborg, Freja & Gether, Ulrik, 2023, In: Journal of Biological Chemistry. 299, 8, 14 p., 105063.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

    Stolzenberg, S., Quick, M., Zhao, C., Gotfryd, K., Khelashvili, G., Gether, Ulrik, Loland, Claus Juul, Javitch, J. A., Noskov, S., Weinstein, H. & Shi, L., 2015, In: The Journal of Biological Chemistry. 290, 22, p. 13992-4003 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    In vivo amphetamine action is contingent on αCaMKII

    Steinkellner, T., Mus, L., Eisenrauch, B., Constantinescu, A., Leo, D., Konrad, L., Rickhag, Karl Mattias, Sørensen, G., Efimova, E. V., Kong, E., Willeit, M., Sotnikova, T. D., Kudlacek, O., Gether, Ulrik, Freissmuth, M., Pollak, D. D., Gainetdinov, R. R. & Sitte, H. H., Oct 2014, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 39, 11, p. 2681-93 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Amphetamine Action at the Cocaine- and Antidepressant-Sensitive Serotonin Transporter Is Modulated by αCaMKII

    Steinkellner, T., Montgomery, T. R., Hofmaier, T., Kudlacek, O., Yang, J., Rickhag, Karl Mattias, Jung, G., Lubec, G., Gether, Ulrik, Freissmuth, M. & Sitte, H. H., 2015, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35, 21, p. 8258-8271 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    The Environment Shapes the Inner Vestibule of LeuT

    Sohail, A., Jayaraman, K., Venkatesan, S., Gotfryd, K., Daerr, M., Gether, Ulrik, Loland, Claus Juul, Wanner, K. T., Freissmuth, M., Sitte, H. H., Sandtner, W. & Stockner, T., Nov 2016, In: PLoS Computational Biology. 12, 11, 24 p., e1005197.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Functional regulation of amphetamine-induced efflux by CaMKII

    Sitte, H. H., Steinkellner, T., Montgomery, T. R., Hofmaier, T., Kudlacek, O., Yang, J., Jung, G., Lubec, G., Gether, Ulrik, Freissmuth, M. & Pollak, D. D., Aug 2015, In: Amino Acids. 47, 8, p. 1659-1659 1 p.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  18. Published

    A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT

    Simmons, K. J., Gotfryd, K., Billesbølle, C. B., Loland, Claus Juul, Gether, Ulrik, Fishwick, C. W. G. & Johnson, A. P., Mar 2013, In: Molecular Membrane Biology. 30, 2, p. 184-94 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

    Seifert, R., Gether, Ulrik, Wenzel-Seifert, K. & Kobilka, B. K., 1999, In: Molecular Pharmacology. 56, p. 348-358

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-Gsalpha fusion protein

    Seifert, R., Wenzel-Seifert, K., Gether, Ulrik, Lam, V. T. & Kobilka, B. K., 1999, In: European Journal of Biochemistry. 260, p. 661-666

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations

    Seifert, R., Wenzel-Seifert, K., Gether, Ulrik & Kobilka, B. K., 2001, In: Journal of Pharmacology and Experimental Therapeutics. 297 (3), p. 1218-1226

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Molecular mechanism of action of non-peptide ligands for peptide receptors

    Schwartz, Thue W., Gether, Ulrik, Schambye, H. T. & Hjorth, Siv Annegrethe, Oct 1995, In: Current Pharmaceutical Design. 1, 3, p. 325-342 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    The role of zinc ions in reverse transport mediated by monoamine transporters

    Scholze, P., Nørregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 14 Jun 2002, In: Journal of Biological Chemistry. 277, 24, p. 21505-13 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    The role of zine ions in reverse transport mediated by monoamine transporters

    Scholze, P., Norregaard, L., Singer, E. A., Freissmuth, M., Gether, Ulrik & Sitte, H. H., 2002, In: Journal of Biological Chemistry. 277, p. 21505-21513

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution

    Schmidt, S. G., Gether, Ulrik & Loland, Claus Juul, 2022, In: Neurochemical Research. 47, p. 127–137 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges

    Runegaard, A. H., Fitzpatrick, C. M., Woldbye, David Paul Drucker, Andreasen T., Jesper, Sørensen, Andreas Toft & Gether, Ulrik, 2019, In: Pharmacological Reviews. 71, 2, p. 123-156 34 p.

    Research output: Contribution to journal › Review › Research › peer-review

  27. Published

    Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

    Runegaard, A. H., Jensen, Kathrine Louise, Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2017, In: Journal of Neuroscience Methods. 289, p. 85-92 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization

    Runegaard, A. H., Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2019, In: Neuropharmacology. 161, 107663.

    Research output: Contribution to journal › Review › Research › peer-review

  29. Published

    Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol

    Runegaard, A. H., Jensen, Kathrine Louise, Wörtwein, Gitta & Gether, Ulrik, 2019, In: European Journal of Neuroscience. 50, 3, p. 2156-2163 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons

    Runegaard, A. H., Sørensen, Andreas Toft, Fitzpatrick, C. M., Jørgensen, Søren Heide, Petersen, A. V., Hansen, Nikolaj Winther, Weikop, Pia, Andreasen T., Jesper, Mikkelsen, Jens D., Perrier, Jean-Francois Marie, Woldbye, David Paul Drucker, Rickhag, Karl Mattias, Wörtwein, Gitta & Gether, Ulrik, 2018, In: eNeuro. 5, 3, 26 p., e0345.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.

    Rickhag, Karl Mattias, Owens, W., Winkler, M., Strandfelt, K. N., Rathje, Mette, Sørensen, G., Andresen, B., Madsen, Kenneth Lindegaard, Nygaard Jørgensen, T., Wörtwein, Gitta, Woldbye, David Paul Drucker, Sitte, H. H., Daws, L. C. & Gether, Ulrik, 2013, In: Journal of Biological Chemistry. 288, p. 27534-44 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter

    Rickhag, Karl Mattias, Herborg, Freja, Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, K., Madsen, Kenneth Lindegaard, Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E., Gomeza, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Gether, Ulrik, 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons

    Rathje, Mette, Fang, H., Bachman, J. L., Anggono, V., Gether, Ulrik, Huganir, R. L. & Madsen, Kenneth Lindegaard, 27 Aug 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 35, p. 14426-31 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Reply to Wilkinson et al. Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling

    Rathje, Mette, Fang, H., Bachman, J. L., Gether, Ulrik, Huganir, R. L. & Madsen, Kenneth Lindegaard, 21 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 3, p. E305 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation

    Rasmussen, T. N., Plenge, P., Bay, T., Egebjerg, J. & Gether, Ulrik, 2009, In: Neuropharmacology. 57, 3, p. 287-94 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Understanding G-protein coupled receptors and their role in the CNS

    Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2002, Structural mechanics of GPCR activation. p. 43-62

    Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research

  37. Published

    Molecular mechanisms of GPCR activation

    Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 2006, G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive ActivityG Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity. 2006: Wiley, Vol. 24. p. 27-42 16 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication

  38. Published

    Mutation of a conserved aspartic acid in the Beta2 adrenergic recptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment VI

    Rasmussen, Søren Gøgsig Faarup, Dam Jensen, A., Ghanouni, P., Liapakis, G., Javitch, J. & Gether, Ulrik, 1999, In: Molecular Pharmacology. 56, p. 175-184

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter

    Rasmussen, Søren Gøgsig Faarup, Carroll, F. I., Maresch, M. J., Jensen, A. D. & Gether, Ulrik, 2001, In: Journal of Biological Chemistry. 276 (7), p. 4717-4723

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy

    Rasmussen, Søren Gøgsig Faarup, Adkins, E. M., Carroll, F. I., Maresch, M. J. & Gether, Ulrik, 31 Oct 2003, In: European Journal of Pharmacology. 479, 1-3, p. 13-22 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Purification and fluorescent labeling of the human serotonin transporter

    Rasmussen, Søren Gøgsig Faarup & Gether, Ulrik, 8 Mar 2005, In: Biochemistry. 44, 9, p. 3494-505 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation

    Rajamanickam, J., Annamalai, B., Rahbek-Clemmensen, T., Sundaramurthy, S., Gether, Ulrik, Jayanthi, L. D. & Ramamoorthy, S., 15 May 2015, In: Biochemical Journal. 468, 1, p. 177-190 14 p., BJ20140826.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

    Rahbek-Clemmensen, T., Lycas, M. D., qrc243, qrc243, Eriksen, J., Apuschkin, Mia, Vilhardt, Frederik, Jorgensen, T. N., Herborg, Freja & Gether, Ulrik, 2017, In: Nature Communications. 8, 14 p., 740.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation

    Rahbek-Clemmensen, T., Bay, T., Eriksen, J., Gether, Ulrik & Jørgensen, T. N., 27 Jun 2014, In: The Journal of Biological Chemistry. 289, p. 23004-23019 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

    Plenge, P., Abramyan, A. M., Sørensen, G., Mork, A., Weikop, Pia, Gether, Ulrik, Bang-Andersen, B., Shi, L. & Loland, Claus Juul, 2020, In: Nature Communications. 11, 1, 12 p., 1491.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites

    Plenge, P., Gether, Ulrik & Rasmussen, Søren Gøgsig Faarup, 2007, In: European Journal of Pharmacology. 567, 1-2, p. 1-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter

    Plenge, P., Shi, L., Beuming, T., Te, J., Newman, A. H., Weinstein, H., Gether, Ulrik & Loland, Claus Juul, 16 Nov 2012, In: The Journal of Biological Chemistry. 287, 47, p. 39316-26 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    The effect of pH on ß2 adrenoceptor function

    Pejman, G., Hans, S., Roland, S., Tae Weon, L., Rasmussen, Søren Gøgsig Faarup, Gether, Ulrik & Kobilka, B. K., 2000, In: Journal of Biological Chemistry. 5, Vol. 275, p. 3121-3127

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Introducing tetraCys motifs at two different sites results in a functional dopamine transporter

    Orun, O., Rasmussen, S. & Gether, Ulrik, 2009, In: Acta Biologica Hungarica. 60, 1, p. 15-25 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Copy number variations in affective disorders and meta-analysis

    Olsen, L., Hansen, T., Djurovic, S., Haastrup, E., Albrecthsen, A., Hoeffding, L. K. E., Secher, A., Gustafsson, O., Jakobsen, K. D., Nielsen, Finn Cilius, Ullum, H., Morken, G., Agartz, I., Melle, I., Gether, Ulrik, Andreassen, O. A. & Werge, Thomas, 2011, In: Psychiatric Genetics. 21, 6, p. 319-322 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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