Uffe Kristiansen

Uffe Kristiansen

Associate Professor

ORCID: 0000-0001-9050-7806

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  1. Published

    4-PIOL, a low-efficacy partial GABA-A agonist

    Frølund, Bente, Kristiansen, Uffe, Nathan, T., Falch, E., Lambert, J. D. C. & Krogsgaard-Larsen, Povl, 1991, Drug Research related to Neuroactive Amino Acids. Munksgaard

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  2. Published

    5-Substituted imidazole-4-acetic acid analogues: Synthesis, modeling, and pharmacological characterization of a series of novel γ-aminobutyric acidC receptor agonists

    Madsen, C., Jensen, Anders A., Liljefors, T., Kristiansen, Uffe, Nielsen, Birgitte, Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, Povl & Frølund, Bente, 2007, In: Journal of Medicinal Chemistry. 50, p. 4147-4161

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    5-substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel ¿-aminobutyric acidC receptor agonists

    Madsen, C., Jensen, A. A., Liljefors, T., Kristiansen, Uffe, Nielsen, Birgitte, Hansen, C. P., Larsen, M., Ebert, B., Bang-Andersen, B., Krogsgaard-Larsen, Povl & Frølund, Bente, 2007, In: Journal of Medicinal Chemistry. 50, 17, p. 4147-4161

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    A Novel Class of Potent 3-Isoxazolol GABAA Antagonists: Design, Synthesis, and Pharmacology

    Frølund, Bente, Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 2000, In: Journal of Medicinal Chemistry. 43, p. 4930–4933

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A novel class of potent 3-isoxazolol GABAA antagonists: Design, systhesis, and pharmacology [3]

    Frølund, Bente, Tagmose, L., Liljefors, T., Stensbøl, T. B., Engblom, C., Kristiansen, Uffe & Krogsgaard-Larsen, Povl, 28 Dec 2000, In: Journal of Medicinal Chemistry. 43, 26, p. 4930-4933 4 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  6. Published

    A single glycine residue at the entrance to the first membrane-spanning domain of the γ-aminobutyric acid type a receptor β2 subunit affects allosteric sensitivity to GABA and anesthetics

    Carlson, B. X., Engblom, A. C., Kristiansen, Uffe, Schousboe, Arne & Olsen, R. W., 2000, In: Molecular Pharmacology. 57, 3, p. 474-484 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Activation of single heteromeric GABAA receptor ion channels by full and partial agonists

    Mortensen, M., Kristiansen, Uffe, Ebert, B., Frølund, Bente, Krogsgaard-Larsen, Povl & Smart, T. G., 1 Jun 2004, In: Journal of Physiology. 557, 2, p. 389-413 25 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Activation on single heteromeric GABAA receptor Ion channels by full and partial agonists

    Mortensen, M., Kristiansen, Uffe, Ebert, B., Frølund, Bente, Krogsgaard-Larsen, Povl & Smart, T., 2004, In: Journal of Physiology. p. 393–417

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Acute but not delayed amphetamine treatment improves behavioral outcome in a rat embolic stroke model

    Rasmussen, Rune Skovgaard, Overgaard, K., Kristiansen, Uffe & Johansen, F. F., Sep 2011, In: Neurological Research. 33, 7, p. 774-782 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    An in silico kinetic model of 8-oxo-7,8-dihydro-2-deoxyguanosine and 8-oxo-7,8-dihydroguanosine metabolism from intracellular formation to urinary excretion

    Jørgensen, Anders, Thygesen, M. B., Kristiansen, Uffe & Poulsen, Henrik Enghusen, 2021, In: Scandinavian Journal of Clinical and Laboratory Investigation. 81, 7, p. 540-545

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Anti-histamine effect of Rubia tibetica, used to treat anaphylaxis caused by tick bites in the Pamir Mountains, Afghanistan

    Jeppesen, A. S., Kristiansen, Uffe, Soelberg, Jens & Jäger, A. K., 14 Jun 2012, In: Journal of Ethnopharmacology. 141, 3, p. 1077-1079 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  12. Published

    Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ-subunit-containing GABAA receptors in dentate gyrus granule cells

    Simonsen, C., Boddum, K., von Schoubye, N. L., Kloppenburg, A., Sønderskov, K., Hansen, S. L. & Kristiansen, Uffe, Aug 2017, In: Pharmacology Research & Perspectives. 5, 4, 15 p., e00322.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Astrocytic GABA transporter activity modulates excitatory neurotransmission

    Boddum, K., Jensen, T. P., Magloire, V., Kristiansen, Uffe, Rusakov, D. A., Pavlov, I. & Walker, M. C., 25 Nov 2016, In: Nature Communications. 7, 10 p., 13572.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Benzodiazepine and barbiturate ligands modulate responses of cultured hippocampal neurones to the GABA(A) receptor partial agonist, 4-PIOL

    Kristiansen, Uffe & Lambert, J. D. C., 1996, In: Neuropharmacology. 35, 9-10, p. 1181-1191 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice

    Laursen, B., Mørk, A., Plath, N., Kristiansen, Uffe & Bastlund, J. F., 1 Mar 2013, In: Behavioural Brain Research. 240, 1, p. 146-52 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 Receptors

    Gasiorek, A., Trattnig, S. M., Ahring, P. K., Kristiansen, Uffe, Frølund, Bente, Frederiksen, K. & Jensen, Anders A., 2016, In: Biochemical Pharmacology. 110-111, p. 92-108 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr128Ala variant (rs2257020) in Xenopus oocytes

    Madjroh, Nawid, Davies, P. A., Smalley, J. L., Kristiansen, Uffe, Söderhielm, P. C. & Jensen, Anders A., 2021, In: Pharmacological Research. 169, 18 p., 105653.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABAA antagonists

    Frølund, Bente, Tagmose, L., Jørgensen, A. T., Kristiansen, Uffe, Stensbøl, T. B., Liljefors, T. & Krogsgaard-Larsen, Povl, 2003, In: European Journal of Medicinal Chemistry. 38, p. 447–449

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABAA antagonists

    Frølund, Bente, Tagmose, L., Jørgensen, A. T., Kristiansen, Uffe, Stensbøl, T. B., Liljefors, T. & Krogsgaard-Larsen, Povl, 1 Apr 2003, In: European Journal of Medicinal Chemistry. 38, 4, p. 447-449 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Differences in kinetics of structurally related competitive GABAA receptor antagonists

    Vestergaard, H. T., Cannillo, C., Frølund, Bente & Kristiansen, Uffe, 2007, In: Neuropharmacology. 52, 3, p. 873-882

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Direct Optical Detection of Singlet Oxygen from a Single Cell

    Zebger, I., Snyder, J. W., Andersen, L. K., Poulsen, L., Gao, Z., Lambert, J. D. C., Kristiansen, Uffe & Ogilby, P. R., Apr 2004, In: Photochemistry and Photobiology. 79, 4, p. 319-322 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors

    Falk-Petersen, C. B., Tsonkov, T. M., Nielsen, M. S., Harpsøe, Kasper, Bundgaard, C., Frølund, Bente, Kristiansen, Uffe, Gloriam, David E. & Wellendorph, Petrine, 22 Jun 2020, In: Scientific Reports. 10, 1, 12 p., 10078.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Does brain slices from pentylenetetrazole-kindled mice provide a more predictive screening model for antiepileptic drugs?

    Hansen, S. L., Sterjev, Z., Werngreen, M., Simonsen, B. J., Knudsen, K. E., Nielsen, A. H., Pedersen, M. E., Badolo, L., Kristiansen, Uffe & Vestergaard, H. T., May 2012, In: European Journal of Pharmacology. 682, 1-3, p. 43-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Effect of Rhoicissus digitata extracts on acetylcholine-mediated contraction in rat uterus

    Schou, J., Kristiansen, Uffe, Stafford, G. I., van Heerden, F. & Jäger, A., Aug 2010, In: Planta Medica. 76, 12, p. 1217

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  25. Published

    Effect of acute injections of the ketone bodies in PTZ kindled mice

    Hansen, S. L., Riisberg, M., Nouri-Nejad, A., Skonberg, C., Kristiansen, Uffe & Hansen, Harald S., 2008.

    Research output: Contribution to conference › Poster › Research

  26. Published

    Effects of GABAA receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions

    Hansen, S. L., Ebert, B., Fjalland, B. & Kristiansen, Uffe, 2001, In: British Journal of Pharmacology. 133, 4, p. 539-549 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Effekt og bivirkninger: GABA fra A til C.

    Frølund, Bente, Madsen, C., Jensen, Anders A., Kristiansen, Uffe & Liljefors, T., 2006, In: Lægemiddelforskning. p. 32-33

    Research output: Contribution to journal › Journal article › Communication

  28. Published

    Electrophysiological studies of the GABAA receptor ligand, 4‐PIOL, on cultured hippocampal neurones

    Kristiansen, Uffe, Lambert, J. D. C., Falch, E. & Krogsgaard-Larsen, Povl, Sep 1991, In: British Journal of Pharmacology. 104, 1, p. 85-90 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay

    Jensen, Anders A. & Kristiansen, Uffe, 2004, In: Biochemical Pharmacology. 67, 9, p. 1789-99 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Functional properties of glycine receptors expressed in primary cultures of mouse cerebellar granule cells

    Elster, L., Banke, T., Kristiansen, Uffe, Schousboe, Arne & Wahl, P., May 1998, In: Neuroscience. 84, 2, p. 519-28 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    GABA(A) and GABA(B) receptor agonists, partial agonists, antagonists and modulators: Design and therapeutic prospects

    Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., Nov 1997, In: European Journal of Pharmaceutical Sciences. 5, 6, p. 355-384 30 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    GABA(A) receptor ligands and their therapeutic potentials.

    Frølund, Bente, Ebert, B., Kristiansen, Uffe, Liljefors, T. & Krogsgaard-Larsen, Povl, Aug 2002, In: Current Topics in Medicinal Chemistry. 2, 8, p. 817-832 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  33. Published

    GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects

    Frølund, Bente, Krogsgaard-Larsen, Povl, Kristiansen, Uffe, Frydenvang, Karla Andrea & Ebert, B., 1997, In: European Journal of Pharmaceutical Sciences. 4, p. 355–384

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    GABA-B Antagonists: Enantiopharmacology of 5-Amino-4-hydroxy-2-methylvaleric Acid and X-Ray Structure of the Eutomer

    Frydenvang, Karla Andrea, Kristiansen, Uffe, Frølund, Bente, Herdeis, C. & Krogsgaard-Larsen, Povl, 1995, In: Chirality. 7, p. 526–533

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    GABAA receptor ligands and their therapeutic potentials

    Frølund, Bente, Ebert, B., Kristiansen, Uffe, Liljefors, T. & Krogsgaard-Larsen, Povl, 2002, In: Current Topics in Medicinal Chemistry. 2

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology

    Krall, J., Balle, T., Krogsgaard-Larsen, N., Sørensen, T. E., Krogsgaard-Larsen, Povl, Kristiansen, Uffe & Frølund, Bente, 2015, Diversity and functions of GABA receptors: A tribute to Hanns Möhler, Part A. Vol. 72. p. 201-27 27 p. (Advances in Pharmacology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  37. Published

    GABAergic actions on cholinergic laterodorsal tegmental neurons: implications for control of behavioral state

    Kohlmeier, Kristi Anne & Kristiansen, Uffe, 15 Dec 2010, In: Neuroscience. 171, 3, p. 812-29 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    GABAergic actions on cholinergic laterodorsal tegmental neurons: Implications for control of behavioral state

    Kohlmeier, Kristi Anne & Kristiansen, Uffe, 2009, In: Journal of Neuroscience.

    Research output: Contribution to journal › Conference abstract in journal › Research

  39. Published

    Hippocampal P3-Like Auditory Event-Related Potentials are Disrupted in a Rat Model of Cholinergic Degeneration in Alzheimer's Disease: Reversal by Donepezil Treatment: Reversal by Donepezil Treatment

    Laursen, B., Mørk, A., Kristiansen, Uffe & Bastlund, J. F., 2 Jul 2014, In: Journal of Alzheimer's Disease. 42, 4, p. 1179–1189 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function.Synthesis, ionization constants and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

    Lolli, M. L., Hansen, S. L., Rolando, B., Nielsen, Birgitte, Wellendorph, Petrine, Madsen, K., Larsen, O. M., Kristiansen, Uffe, Fruttero, R., Gasco, A. & Johansen, Tommy Nørskov, 2006, In: J. Med. Chem.. 49, p. 4442-4446 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Hydroxylated analogues of 5-aminovaleric acid as 4-aminobutyric acidB receptor antagonists: stereostructure-activity relationships

    Kristiansen, Uffe, bjl587, bjl587, Herdeis, C., Lund, Trine Meldgaard, Nielsen, Birgitte, Hansen, J. J., Falch, E., Hjeds, H. & Krogsgaard-Larsen, Povl, Mar 1992, In: Journal of Neurochemistry. 58, 3, p. 1150-9 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Impaired GABAergic Inhibition in the Prefrontal Cortex of Early Postnatal Phencyclidine (PCP)-Treated Rats

    Kjærby, Celia, Broberg, B. V., Kristiansen, Uffe & Dalby, N. O., 2014, In: Cerebral Cortex. 24, 9, p. 2522-32 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Impaired hippocampal acetylcholine release parallels spatial memory deficits in Tg2576 mice subjected to basal forebrain cholinergic degeneration

    Laursen, B., Mørk, A., Plath, N., Kristiansen, Uffe & Bastlund, J. F., 11 Nov 2013, In: Brain Research. 1543, p. 253-262

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Increasing cellular lifespan with a flow system in organotypic culture of the Laterodorsal Tegmentum (LDT)

    Leguizamon, Cesar Ramon Romero, Elnagar, M., Kristiansen, Uffe & Kohlmeier, Kristi Anne, 6 Feb 2019, In: Scientific Reports. p. 1 - 11 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus

    Hansen, S. L., Nielsen, A. H., Knudsen, K. E., Artmann, A., Kristiansen, Uffe, Hansen, S. H., Hansen, Harald S. & Petersen, G., 2009, In: Neurochemistry International. 54, 3-4, p. 199-204

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Leukocyte infiltration in experimental stroke

    Grønberg, N. V., Johansen, F. F., Kristiansen, Uffe & Hasseldam, Henrik, 18 Sep 2013, In: Journal of Neuroinflammation. 10, 9 p., 115.

    Research output: Contribution to journal › Review › Research › peer-review

  47. Published

    Ligand Structural Specificity of GABAA Receptors in Guinea Pig Ileum

    Kristiansen, Uffe & Fjalland, B., May 1991, In: Pharmacology & Toxicology. 68, 5, p. 332-339 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Ligands for the GABA recognition site at the GABAA receptor: Structure-activity studies

    Frølund, Bente, Kristiansen, Uffe, Krogsgaard-Larsen, Povl & Liljefors, T., 2008, Chemistry and molecular aspects of drug design and action. Rekka, E. A. & Kourounakis, P. N. (eds.). Boca Raton, Fl: CRC Press, p. 139-147

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

  49. Published

    Ligands for the GABAA receptor complex

    Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe & Ebert, B., 1 Jan 2001, Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology. CRC Press, p. 236-274 39 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  50. Published

    Ligands for the GABAA receptor complex

    Krogsgaard-Larsen, Povl, Frølund, Bente, Kristiansen, Uffe & Ebert, B., 2002, Glutamate and GABA receptors of AMPA/kainate receptors and transporters. Taylor & Francis, p. 236–274

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

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ID: 985515