Philip Allan Seymour

Philip Allan Seymour

ORCID: 0000-0001-5782-6020

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  1. Published

    A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells

    Shih, H. P., Seymour, Philip Allan, Patel, N. A., Xie, R., Wang, A., Liu, P. P., Yeo, G. W., Magnuson, M. A. & Sander, M., 13 Oct 2015, In: Cell Reports. 13, 2, p. 326-36 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. A Sox9/Fgf feed-forward loop maintains pancreatic organ identity

    Seymour, Philip Allan, Shih, H. P., Patel, N. A., Freude, Kristine, Xie, R., Lim, C. J. & Sander, M., Sep 2012, In: Development. 139, 18, p. 3363-72 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened

    Stasiulewicz, M., Gray, S., Mastromina, I., Silva, J. C., Bjorklund, M., Seymour, Philip Allan, Booth, D., Thompson, C., Green, R., Hall, E. A., Serup, Palle & Dale, J. K., 2015, In: Development. 142, p. 2291-2303 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation

    Seymour, Philip Allan, Freude, Kristine, Dubois, C. L., Shih, H., Patel, N. A. & Sander, M., 1 Nov 2008, In: Advances in Developmental Biology. 323, 1, p. 19-30 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Bulking up on beta cells

    Seymour, Philip Allan & Serup, Palle, 22 Aug 2013, In: Briefings from the New England Journal of Medicine (Spanish Edition). 369, 8, p. 777-9 3 p.

    Research output: Contribution to journal › Review › Research › peer-review

  6. Published

    Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development

    Liu, D., Kousa, A. I., O'Neill, K. E., Rouse, P., Popis, M., Farley, A. M., Tomlinson, S. R., Ulyanchenko, Svetlana, Guillemot, F., Seymour, Philip Allan, Jørgensen, Mette Christine, Serup, Palle, Koch, U., Radtke, F. & Blackburn, C. C., 2020, In: Development (Cambridge, England). 147, p. 1-16 dev178582.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons

    Seymour, Philip Allan & Serup, Palle, 2023, In: Genes & Development. 37, 11-12, p. 451-453 3 p.

    Research output: Contribution to journal › Review › Research › peer-review

  8. Fission of pancreatic islets during postnatal growth of the mouse

    Seymour, Philip Allan, Bennett, W. R. & Slack, J. M. W., Feb 2004, In: Journal of Anatomy. 204, 2, p. 103-16 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development

    Seymour, Philip Allan & Sander, M., Feb 2011, In: Diabetes. 60, 2, p. 364-76 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Immunohistochemical detection of beta-galactosidase or green fluorescent protein on tissue sections

    Seymour, Philip Allan & Sander, M., 2007, In: Methods in Molecular Biology. 411, p. 13-23 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors

    Liu, K., Leuckx, G., Sakano, D., Seymour, Philip Allan, Mattsson, C. L., Rautio, L., Staels, W., Verdonck, Y., Serup, Palle, Kume, S., Heimberg, H. & Andersson, O., Jan 2018, In: Diabetes. 67, 1, p. 58-70 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

    Seymour, Philip Allan, Collin, C. A., Egeskov-Madsen, A. L. R., Jørgensen, Mette Christine, Shimojo, H., Imayoshi, I., de Lichtenberg, K. H., Kopan, R., Kageyama, R. & Serup, Palle, 2020, In: Developmental Cell. 52, 6, p. 731-747.e8 26 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

    sgk681, sgk681, Seymour, Philip Allan, Sneppen, Kim, Trusina, Ala, Egeskov-Madsen, A. L. R., Jørgensen, Mette Christine, Jensen, Mogens Høgh & Serup, Palle, 2023, In: Nature Communications. 14, 17 p., 348.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

    Mamidi, A., Prawiro, C., Seymour, Philip Allan, de Lichtenberg, K. H., Jackson, Abigail Laura, Serup, Palle & Semb, Tor Henrik, Dec 2018, In: Nature. 564, 7734, p. 114-118 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  15. Published

    Mesodermal induction of pancreatic fate commitment

    Seymour, Philip Allan & Serup, Palle, Aug 2019, In: Seminars in Cell and Developmental Biology. 92, p. 77-88

    Research output: Contribution to journal › Review › Research › peer-review

  16. Published

    Notch Controls Multiple Pancreatic Cell Fate Regulators Through Direct Hes1-mediated Repression

    de Lichtenberg, K. H., Seymour, Philip Allan, Jørgensen, Mette Christine, Kim, Y., Grapin-Botton, A., Magnuson, M. A., Nakic, N., Ferrer, J. & Serup, Palle, 2018, bioRxiv, 30 p. (bioRxiv, Developmental Biology).

    Research output: Working paper › Preprint › Research

  17. Published

    Pairing-up SOX to kick-start beta cell genesis

    Grapin-Botton, A., Seymour, Philip Allan & Gradwohl, G., May 2015, In: Diabetologia. 58, 5, p. 859-861 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice

    Mellitzer, G., Martín, M., Sidhoum-Jenny, M., Orvain, C., Barths, J., Seymour, Philip Allan, Sander, M. & Gradwohl, G., Nov 2004, In: Molecular Endocrinology. 18, 11, p. 2765-76 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo

    Horn, S., Kirkegaard, J. S., Hoelper, S., Seymour, Philip Allan, Rescan, C., Nielsen, Jens Høiriis, Madsen, O. D., Jensen, J. N., Kruger, M., Gronborg, M. & Ahnfelt-Rønne, J., 2016, In: Molecular endocrinology (Baltimore, Md.). 30, 1, p. 133-143 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. SOX9 is required for maintenance of the pancreatic progenitor cell pool

    Seymour, Philip Allan, Freude, Kristine, Tran, M. N., Mayes, E. E., Jensen, J., Kist, R., Scherer, G. & Sander, M., 6 Feb 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 6, p. 1865-70 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Sox9: a master regulator of the pancreatic program

    Seymour, Philip Allan, 2014, In: The Review of Diabetic Studies. 11, 1, p. 51-83 33 p.

    Research output: Contribution to journal › Review › Research › peer-review

  22. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

    Kopp, J. L., Dubois, C. L., Schaffer, A. E., Hao, E., Shih, H. P., Seymour, Philip Allan, Ma, J. & Sander, M., Feb 2011, In: Development. 138, 4, p. 653-65 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Sox9-haploinsufficiency causes glucose intolerance in mice

    Dubois, C. L., Shih, H. P., Seymour, Philip Allan, Patel, N. A., Behrmann, J. M., Ngo, V. & Sander, M., 2011, In: P L o S One. 6, 8, p. e23131

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function

    Wang, S., Jensen, J. N., Seymour, Philip Allan, Hsu, W., Dor, Y., Sander, M., Magnuson, M. A., Serup, P. & Gu, G., 16 Jun 2009, In: PNAS Early Edition. 106, 24, p. 9715-20 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 40446254