Per Mårten Hägglund
Associate Professor
Inflammation, Metabolism and Oxidation
Blegdamsvej 3
2200 København N.
Lactococcus lactis Thioredoxin Reductase is Sensitive to Light Inactivation
Björnberg, O., Viennet, T., Skjoldager, N., Ćurović, A., Nielsen, K. F., Svensson, B. & Hägglund, Per Mårten, 2015, In: Biochemistry. 54, 8, p. 1628-1637 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Lactococcus lactis TrxD represents a subgroup of thioredoxins prevalent in Gram-positive bacteria containing WCXDC active site motifs
Björnberg, O., Efler, P., Ebong, E. D., Svensson, B. & Hägglund, Per Mårten, 2014, In: Archives of Biochemistry and Biophysics. 564, p. 164-172 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Levels of circulating MMP-7 degraded elastin are elevated in pulmonary disorders
Kristensen, J. H., Larsen, L., Dasgupta, B., Brodmerkel, C., Curran, M., Karsdal, M. A., Sand, J. M. B., Willumsen, N., Knox, A. J., Bolton, C. E., Johnson, S. R., Hägglund, Per Mårten, Svensson, B. & Leeming, D. J., 2015, In: Clinical Biochemistry. 48, 16-17, p. 1083-1088 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MMP mediated degradation of type VI collagen is highly associated with liver fibrosis--identification and validation of a novel biochemical marker assay
Veidal, S. S., Karsdal, M. A., Vassiliadis, E., Nawrocki, A., Larsen, M. R., Nguyen, Q. H. T., Hägglund, Per Mårten, Luo, Y., Zheng, Q., Vainer, B. & Leeming, D. J., 2011, In: P L o S One. 6, 9, p. e24753Research output: Contribution to journal › Journal article › Research › peer-review
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Mapping the modification of histones by the myeloperoxidase-derived oxidant hypochlorous acid (HOCl)
Hallberg, L. A. E., Thorsen, N. W., Hartsema, E. A., Hägglund, Per Mårten & Hawkins, Clare Louise, 2022, In: Free Radical Biology and Medicine. 192, p. 152-164 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mass-Spectrometry-Based Identification of Cross-Links in Proteins Exposed to Photo-Oxidation and Peroxyl Radicals Using 18O Labeling and Optimized Tandem Mass Spectrometry Fragmentation
Mariotti, M., Leinisch, F., Leeming, D. J., Svensson, B., Davies, Michael J. & Hägglund, Per Mårten, 2018, In: Journal of Proteome Research. 17, 6, p. 2017-2027Research output: Contribution to journal › Journal article › Research › peer-review
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Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation
Mozzicato, Anthony Michael, Bastrup, Joakim Armstrong, Sanchez-Alonso, J. L., van der Horst, Jennifer, Gorelik, J., Hägglund, Per Mårten & Jepps, Thomas Andrew Qvistgaard, 2024, In: The Biochemical journal. 481, 5, p. 387-403Research output: Contribution to journal › Journal article › Research › peer-review
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Metabolic Profiling of Interspecies Interactions During Sessile Bacterial Cultivation Reveals Growth and Sporulation Induction in Paenibacillus amylolyticus in Response to Xanthomonas retroflexus
Herschend, J., Ernst, M., Koren, K., Melnik, A. V., da Silva, R. R., Røder, Henriette Lyng, Damholt, Z. B. V., Hägglund, Per Mårten, Svensson, B., Sørensen, Søren Johannes, Kühl, Michael, Dorrestein, P. C. & Burmølle, Mette, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 17 p., 805473.Research output: Contribution to journal › Journal article › Research › peer-review
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Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway
Shu, N., Hägglund, Per Mårten, Cai, H., Hawkins, Clare Louise & Davies, Michael J., Jan 2020, In: Redox Biology. 29, UNSP 101400.Research output: Contribution to journal › Journal article › Research › peer-review
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Modification of Cys residues in thioredoxin by p-benzoquinone causes inhibition of its catalytic activity and activation of ASK1/p38-MAPK signalling pathway: [Meeting Abstract]
Shu, N., Hägglund, Per Mårten & Davies, Michael J., 1 Aug 2019, In: Free Radical Biology and Medicine. 139, S1, p. S9-S9 8.Research output: Contribution to journal › Conference abstract in journal › Research
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Modification-specific proteomic analysis of glycoproteins in human body fluids by mass spectrometry
Bunkenborg, J., Hägglund, Per Mårten & Jensen, O. N., 1 Jan 2007, Proteomics of Human Body Fluids: Principles, Methods, and Applications. Humana Press, p. 107-128 22 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Molecular characterization of major cat allergen Fel d 1: Expression of heterodimer by use of a baculovirus expression system
Seppälä, U., Hägglund, Per Mårten, Wurtzen, P. A., Ipsen, H., Thorsted, P., Lenhard, T., Roepstorff, P. & Spangfort, M. D., 4 Feb 2005, In: Journal of Biological Chemistry. 280, 5, p. 3208-3216 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation
Campolo, N., Mastrogiovanni, M., Mariotti, M., Issoglio, F. M., Estrin, D., Hägglund, Per Mårten, Grune, T., Davies, Michael J., Bartesaghi, S. & Radi, R., 2023, In: Journal of Biological Chemistry. 299, 3, 22 p., 102941.Research output: Contribution to journal › Journal article › Research › peer-review
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New Insights into the Potential of Endogenous Redox Systems in Wheat Bread Dough
Navrot, N., Holstborg, R. B., Hägglund, Per Mårten, Povlsen, I. L. & Svensson, B., Dec 2018, In: Antioxidants. 7, 12, 190 .Research output: Contribution to journal › Journal article › Research › peer-review
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New insight into the composition of extracellular traps released by macrophages exposed to different types of inducers
Jensen, M., Thorsen, N. W., Hallberg, L. A. E., Hägglund, Per Mårten & Hawkins, Clare Louise, 2023, In: Free Radical Biology and Medicine. 202, p. 97-109 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oxidation of lysozyme induced by peroxyl radicals involves amino acid modifications, loss of activity, and formation of specific crosslinks
Fuentes Lemus, Eduardo, Mariotti, M., Hägglund, Per Mårten, Leinisch, F., Fierro, A., Silva, E., Davies, Michael J. & Lopez-Alarcon, C., 2021, In: Free Radical Biology and Medicine. 167, p. 258-270Research output: Contribution to journal › Journal article › Research › peer-review
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Oxidative Crosslinking of Peptides and Proteins: Mechanisms of Formation, Detection, Characterization and Quantification
Fuentes Lemus, Eduardo, Hägglund, Per Mårten, López-Alarcón, C. & Davies, Michael J., 1 Jan 2022, In: Molecules. 27, 1, p. 1-31 15.Research output: Contribution to journal › Review › Research › peer-review
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Peroxyl radical- and photo-oxidation of glucose 6-phosphate dehydrogenase generates cross-links and functional changes via oxidation of tyrosine and tryptophan residues
Leinisch, F., Mariotti, M., Rykaer, M., López-Alarcón, C., Hägglund, Per Mårten & Davies, Michael J., Nov 2017, In: Free Radical Biology & Medicine. 112, p. 240-252 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Peroxynitrous acid (ONOOH) modifies the structure of anastellin and influences its capacity to polymerize fibronectin
He, Jianfei, Becares, E. R., Thulstrup, Peter Waaben, Gamon, Luke Francis, Pedersen, J. N., Otzen, D., Gourdon, Pontus Emanuel, Davies, Michael J. & Hägglund, Per Mårten, 2020, In: Redox Biology. 36, 11 p., 101631.Research output: Contribution to journal › Journal article › Research › peer-review
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Photo -oxidation of lysozyme triggered by riboflavin is O 2-dependent, occurs via mixed type 1 and type 2 pathways, and results in inactivation, site-specific damage and intra- and inter -molecular crosslinks
Fuentes-Lemus, E., Mariotti, M., Reyes, J., Leinisch, F., Hägglund, Per Mårten, Silva, E., Davies, Michael J. & Lopez-Alarcon, C., 2020, In: Free Radical Biology and Medicine. 152, p. 61-73Research output: Contribution to journal › Journal article › Research › peer-review
Plant redox proteomics
Navrot, N., Finnie, C., Svensson, B. & Hägglund, Per Mårten, 2011, In: Journal of Proteomics. 74, 8, p. 1450-1462 13 p.Research output: Contribution to journal › Review › Research › peer-review
Proteomics of Disulphide and Cysteine Oxidoreduction
Maeda, K., Hägglund, Per Mårten, Finnie, C. & Svensson, B., 2007, Plant Proteomics. Wiley, p. 71-97 27 p. (Annual Plant Reviews, Vol. 28).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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ROLE OF EXTRACELLULAR TRAP RELEASE BY MACROPHAGES DURING THE DEVELOPMENT OF CHRONIC INFLAMMATION.
Jensen, M., Hägglund, Per Mårten, Zhang, Y., Rayner, B. & Hawkins, Clare Louise, 2021, In: Atherosclerosis. 331, p. E72-E72 PO51.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Role of amino acid oxidation and protein unfolding in peroxyl radical and peroxynitrite-induced inactivation of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides
Figueroa, J. D., Fuentes Lemus, Eduardo, Reyes, J. S., Loaiza, M., Aliaga, M. E., Fierro, A., Leinisch, F., Hägglund, Per Mårten, Davies, Michael J. & López-Alarcón, C., 2022, In: Free Radical Biology and Medicine. 190, p. 292-306Research output: Contribution to journal › Journal article › Research › peer-review
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Seed thioredoxin h
Hägglund, Per Mårten, Finnie, C., Yano, H., Shahpiri, A., Buchanan, B. B., Henriksen, A. & Svensson, B., 1 Aug 2016, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1864, 8, p. 974-982 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Serological assessment of neutrophil elastase activity on elastin during lung ECM remodeling
Kristensen, J. H., Karsdal, M. A., Sand, J. M. B., Willumsen, N., Diefenbach, C., Svensson, B., Hägglund, Per Mårten & Oersnes-Leeming, D. J., 2015, In: BMC Pulmonary Medicine. 15, 1, 53.Research output: Contribution to journal › Journal article › Research › peer-review
Structural Basis for Target Protein Recognition by the Protein Disulfide Reductase Thioredoxin
Maeda, K., Hägglund, Per Mårten, Finnie, C., Svensson, B. & Henriksen, A., 2006, In: Structure. 14, 11, p. 1701-1710 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and functional changes in RNAse A originating from tyrosine and histidine cross-linking and oxidation induced by singlet oxygen and peroxyl radicals
Leinisch, F., Mariotti, M., Hägglund, Per Mårten & Davies, Michael J., Oct 2018, In: Free Radical Biology and Medicine. 126, p. 73-86Research output: Contribution to journal › Journal article › Research › peer-review
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Structural aspects in semicrystalline samples of the mannan II family
Heux, L., Hägglund, Per Mårten, Putaux, J. L. & Chanzy, H., 1 Jan 2005, In: Biomacromolecules. 6, 1, p. 324-332 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Structure of Hordeum vulgare NADPH-dependent thioredoxin reductase 2. Unwinding the reaction mechanism
Kirkensgaard, Kristine Groth, Hägglund, Per Mårten, Finnie, C., Svensson, B. & Henriksen, A., 2009, In: Acta Crystallographica Section D: Biological Crystallography. 65, 9, p. 932-941 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Surface Binding Sites (SBSs), Mechanism and Regulation of Enzymes Degrading Amylopectin and α-Limit Dextrins
S. Møller, M., Cockburn, D., W. Nielsen, J., M. Jensen, J., B. Vester-christensen, M., M. Nielsen, M., M. Andersen, J., Wilkens, C., Rannes, J., Hägglund, Per Mårten, Henriksen, A., Abou Hachem, M., Willemoës, Martin & Svensson, B., 1 Jan 2013, In: Journal of Applied Glycoscience. 60, 2, p. 101-109Research output: Contribution to journal › Review › Research › peer-review
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The Reducing Capacity of Thioredoxin on Oxidized Thiols in Boiled Wort
Murmann, A. N., Hägglund, Per Mårten, Svensson, B. & Lund, Marianne N., 2017, In: Journal of Agricultural and Food Chemistry. 65, 46, p. 10101-10106 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
The barley grain thioredoxin system – an update
Hägglund, Per Mårten, Björnberg, O., Navrot, N., Jensen, J. M., Maeda, K., Kirkensgaard, Kristine Groth, Shahpiri, A., Sultan, A., Bunkenborg, J., Gubler, F., Barrero, J. M., Henriksen, A., Finnie, C. & Svensson, B., 2013, In: Frontiers in Plant Science. 4, 5 p., 151.Research output: Contribution to journal › Journal article › Research › peer-review
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The cysteine residue in beta-lactoglobulin reacts with oxidized tyrosine residues in beta-casein to give casein-lactoglobulin dimers
Doblas, L., Hägglund, Per Mårten, Fuentes Lemus, Eduardo & Davies, Michael J., 2023, In: Archives of Biochemistry and Biophysics. 733, 7 p., 109482.Research output: Contribution to journal › Journal article › Research › peer-review
The role of extracellular matrix quality in pulmonary fibrosis
Kristensen, J. H., Karsdal, M. A., Genovese, F., Johnson, S., Svensson, B., Jacobsen, S., Hägglund, Per Mårten & Leeming, D. J., 2014, In: Respiration. 88, 6, p. 487-499 13 p.Research output: Contribution to journal › Review › Research › peer-review
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The role of subsite 2 of the Trichoderma reesei β-mannanase TrMan5A in hydrolysis and transglycosylation
Rosengren, A., Hägglund, Per Mårten, Anderson, L., Pavon-Orozco, P., Peterson-Wulff, R., Nerinckx, W. & Stålbrand, H., 1 May 2012, In: Biocatalysis and Biotransformation. 30, 3, p. 338-352 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of Lactococcus lactis thioredoxin reductase reveals molecular features of photo-oxidative damage
Skjoldager, N., Blanner Bang, M., Rykaer, M., Björnberg, O., Davies, Michael J., Svensson, B., Harris, P. & Hägglund, Per Mårten, Apr 2017, In: Scientific Reports. 7, 10 p., 46282.Research output: Contribution to journal › Journal article › Research › peer-review
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Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo
Kjelgaard-Petersen, C. F., Sharma, N., Kayed, A., Karsdal, M. A., Mobasheri, A., Hägglund, Per Mårten, Bay-Jensen, A. & Thudium, C. S., 2019, In: Biochemical Pharmacology. 165, p. 91-98Research output: Contribution to journal › Journal article › Research › peer-review
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Tryptophan and Cysteine residues mediate chain reactions and propagation of oxidative damage in concentrated casein solutions
Fuentes Lemus, Eduardo, Jiang, S., Hägglund, Per Mårten & Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 177, Suppl. 1, p. 562 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
Two Lactococcus lactis thioredoxin paralogues play different roles in responses to arsenate and oxidative stress
Efler, P., Kilstrup, M., Johnsen, S., Svensson, B. & Hägglund, Per Mårten, 2015, In: Microbiology (United Kingdom). 161, 3, p. 528-538 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Two novel S1 peptidases from Amycolatopsis keratinophila subsp. keratinophila D2T degrading keratinous slaughterhouse by-products
Espersen, R., Falco, F. C., Hägglund, Per Mårten, Gernaey, K. V., Lantz, A. E. & Svensson, B., 2020, In: Applied Microbiology and Biotechnology. 104, 6, p. 2513-2522 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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UV oxidation of cyclic AMP receptor protein, a global bacterial gene regulator, decreases DNA binding and cleaves DNA at specific sites
Leinisch, F., Mariotti, M., Andersen, S. H., Lindemose, Søren, Hägglund, Per Mårten, Møllegaard, Niels Erik & Davies, Michael J., 2020, In: Scientific Reports. 10, 1, 11 p., 3106.Research output: Contribution to journal › Journal article › Research › peer-review
Ulcerative colitis, Crohn’s disease, and irritable bowel syndrome have different profiles of extracellular matrix turnover, which also reflects disease activity in Crohn’s disease
Mortensen, J. H., Manon-Jensen, T., Jensen, M. D., Hägglund, Per Mårten, Klinge, L. G., Kjeldsen, J., Krag, A., Karsdal, M. A. & Bay-Jensen, A. C., Oct 2017, In: PLoS ONE. 12, 10, e0185855.Research output: Contribution to journal › Journal article › Research › peer-review
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Unrestricted Mass Spectrometric Data Analysis for Identification, Localization, and Quantification of Oxidative Protein Modifications
Rykær, M., Svensson, B., Davies, Michael J. & Hägglund, Per Mårten, 3 Nov 2017, In: Journal of Proteome Research. 16, 11, p. 3978-3988 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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endo-β-1,4-Mannanases from blue mussel, Mytilus edulis: Purification, characterization, and mode of action
Xu, B., Hägglund, Per Mårten, Stålbrand, H. & Janson, J. C., 18 Jan 2002, In: Journal of Biotechnology. 92, 3, p. 267-277 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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αAmylases. Interaction with Polysaccharide Substrates, Proteinaceous Inhibitors and Regulatory Proteins
Seo, E. S., Nielsen, M. M., Andersen, J. M., Vester-Christensen, M. B., Jensen, J. M., Christiansen, C., Dilokpimol, A., Hachem, M. A., Hägglund, Per Mårten, Maedal, K., Finnie, C., Blennow, Andreas & Svensson, B., 2008, Carbohydrate-Active Enzymes: Structure, Function and Applications. Elsevier, p. 20-36 17 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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A meta-proteomics approach to study the interspecies interactions affecting microbial biofilm development in a model community
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The structure of Lactococcus lactis thioredoxin reductase reveals molecular features of photo-oxidative damage
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122
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Copper ion / H2O2 oxidation of Cu/Zn-Superoxide dismutase: Implications for enzymatic activity and antioxidant action
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