Michael J. Davies

Michael J. Davies

Professor


  1. 2024
  2. Published

    Oxidation of the active site cysteine residue of glyceraldehyde-3-phosphate dehydrogenase to the hyper-oxidized sulfonic acid form is favored under crowded conditions

    Glover, M. R., Davies, Michael J. & Fuentes Lemus, Eduardo, 2024, In: Free Radical Biology and Medicine. 212, p. 1-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Proteomic analysis of the extracellular matrix of human atherosclerotic plaques shows marked changes between plaque types

    Lorentzen, Lasse Gøbel, Yeung, K., Eldrup, Nikolaj, Eiberg, Jonas Peter, Sillesen, Henrik & Davies, Michael J., 2024, In: Matrix Biology Plus. 21, 14 p., 100141.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 2023
  5. Published

    Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

    Anghinoni, J. M., Birmann, P. T., da Rocha, M. J., Gomes, C. S., Davies, Michael J., Brüning, C. A., Savegnago, L. & Lenardão, E. J., 2023, In: Molecules. 28, 21, p. 1-45 7349.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    Multiple oxidative post-translational modifications of human glutamine synthetase mediate peroxynitrite-dependent enzyme inactivation and aggregation

    Campolo, N., Mastrogiovanni, M., Mariotti, M., Issoglio, F. M., Estrin, D., Hägglund, Per Mårten, Grune, T., Davies, Michael J., Bartesaghi, S. & Radi, R., 2023, In: Journal of Biological Chemistry. 299, 3, 22 p., 102941.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Oxidant-modified amylin fibrils and aggregates alter the inflammatory profile of multiple myeloid cell types, but are non-toxic to islet β cells

    Clemen, R., Fuentes Lemus, Eduardo, Bekeschus, S. & Davies, Michael J., 2023, In: Redox Biology. 65, 14 p., 102835.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Myeloperoxidase Alters Lung Cancer Cell Function to Benefit Their Survival

    Cosic-Mujkanovic, N., Valadez-Cosmes, P., Maitz, K., Lueger, A., Mihalic, Z. N., Runtsch, M. C., Kienzl, M., Davies, Michael J., Chuang, Christine, Heinemann, A., Schicho, R., Marsche, G. & Kargl, J., 2023, In: Antioxidants. 12, 8, 17 p., 1587.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The cysteine residue in beta-lactoglobulin reacts with oxidized tyrosine residues in beta-casein to give casein-lactoglobulin dimers

    Doblas, L., Hägglund, Per Mårten, Fuentes Lemus, Eduardo & Davies, Michael J., 2023, In: Archives of Biochemistry and Biophysics. 733, 7 p., 109482.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Complexation of AAPH (2,2′-azobis(2-methylpropionamidine) dihydrochloride) with cucurbit[7]uril enhances the yield of AAPH-derived radicals

    Forero-Girón, A. C., Fuentealba, D., Mariño-Ocampo, N., Gutiérrez-Oliva, S., Herrera, B., Toro-Labbé, A., Fuentes Lemus, Eduardo, Davies, Michael J., Aliaga, M. E. & López-Alarcón, C., 2023, In: Journal of Molecular Liquids. 389, 9 p., 122840.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Effect of crowding, compartmentalization and nanodomains on protein modification and redox signaling – current state and future challenges

    Fuentes Lemus, Eduardo & Davies, Michael J., 2023, In: Free Radical Biology and Medicine. 196, p. 81-92

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published

    The enzymes of the oxidative phase of the pentose phosphate pathway as targets of reactive species: consequences for NADPH production

    Fuentes Lemus, Eduardo, Reyes, J. S., Figueroa, J. D., Davies, Michael J. & López-Alarcón, C., 2023, In: Biochemical Society Transactions. 51, 6, p. 2173–2187

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    The structure of model and peptide disulfides markedly affects their reactivity and products formed with singlet oxygen

    Gao, Qing, Grzyb, K., Gamon, Luke Francis, Ogilby, P. R., Pędziński, T. & Davies, Michael J., 2023, In: Free Radical Biology and Medicine. 207, p. 320-329

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Exposure to peroxynitrite impacts the ability of anastellin to modulate the structure of extracellular matrix

    He, Jianfei, Chuang, Christine, Hawkins, Clare Louise, Davies, Michael J. & Hägglund, Per Mårten, 2023, In: Free Radical Biology and Medicine. 206, p. 83-93 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The inflammatory oxidant peroxynitrous acid modulates the structure and function of the recombinant human V3 isoform of the extracellular matrix proteoglycan versican

    Jørgensen, S. M., Lorentzen, Lasse Gøbel, Hammer, A., Hoefler, G., Malle, E., Chuang, Christine & Davies, Michael J., 2023, In: Redox Biology. 64, 19 p., 102794.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Oxygen Exposure and Tolerance Shapes the Cell Wall-Associated Lipids of the Skin Commensal Cutibacterium acnes

    Popa, I., Touboul, D., Andersson, T., Fuentes Lemus, Eduardo, Santerre, C., Davies, Michael J. & Lood, R., 2023, In: Microorganisms. 11, 9, 15 p., 2260.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Peroxyl radicals modify 6-phosphogluconolactonase from Escherichia coli via oxidation of specific amino acids and aggregation which inhibits enzyme activity

    Reyes, J. S., Fuentes Lemus, Eduardo, Romero, J., Arenas, F., Fierro, A., Davies, Michael J. & López-Alarcón, C., 2023, In: Free Radical Biology and Medicine. 204, p. 118-127

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published
  19. Published

    Detrimental Actions of Chlorinated Nucleosides on the Function and Viability of Insulin-Producing Cells

    Sileikaite-Morvaközi, I., Hansen, W. H., Davies, Michael J., Mandrup-Poulsen, Thomas & Hawkins, Clare Louise, 2023, In: International Journal of Molecular Sciences. 24, 19, 13 p., 14585.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Identification of bile acid-CoA:amino acid N-acyltransferase as the hepatic N-acyl taurine synthase for polyunsaturated fatty acids

    Trammell, Sam, Gamon, Luke Francis, Gotfryd, K., Michler, Katja Thorøe, Alrehaili, B. D., Rix, I., Knop, Filip Krag, Gourdon, Pontus Emanuel, Lee, Y. K., Davies, Michael J., Gillum, M. P. & Grevengoed, Trisha Jean, 2023, In: Journal of Lipid Research. 64, 9, 9 p., 100361.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Treating atopic-dermatitis-like skin lesions in mice with gelatin-alginate films containing 1,4-anhydro-4-seleno-D-talitol (SeTal)

    Voss, G. T., Davies, Michael J., Schiesser, C. H., de Oliveira, R. L., Nornberg, A. B., Soares, V. R., Barcellos, A. M., Luchese, C., Fajardo, A. R. & Wilhelm, E. A., 2023, In: International Journal of Pharmaceutics. 642, 13 p., 123174.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Hypochlorous Acid and Chloramines Induce Specific Fragmentation and Cross-Linking of the G1-IGD-G2 Domains of Recombinant Human Aggrecan, and Inhibit ADAMTS1 Activity

    Wang, Y., Hammer, A., Hoefler, G., Malle, E., Hawkins, Clare Louise, Chuang, Christine & Davies, Michael J., 2023, In: Antioxidants. 12, 2, 25 p., 420.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published
  24. Published

    Genotoxicity assessment of 1,4-anhydro-4-seleno-D-talitol (SeTal) in human liver HepG2 and HepaRG cells

    di Vito, R., Acito, M., Fatigoni, C., Schiesser, C. H., Davies, Michael J., Mangiavacchi, F., Villarini, M., Santi, C. & Moretti, M., 2023, In: Toxicology. 499, 153663.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 2022
  26. Published

    Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase**

    Bolding, J. E., Martín-Gago, P., Rajabi, N., Gamon, Luke Francis, Hansen, T. N., Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Davies, Michael J. & Olsen, Christian Adam, 2022, In: Angewandte Chemie - International Edition. 61, 47, 11 p., e202204565.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Adduction reactions of alpha,beta-unsaturated aldehydes to proteins

    Davies, Michael J., 2022, In: Toxicology Letters. 368, Suppl, p. S62-S62 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  28. Published

    In memoriam: Emeritus Professor Robin L. Willson

    Davies, Michael J., Davies, K. J. A., Halliwell, B., Jackson, M. J., Mann, G. E., Poli, G., Radi, R., Riley, P. A., Sies, H., Ward, J. F., Wardman, P. & Willson, J., 2022, In: Free Radical Research. 56, 7-8, p. 572-576 5 p.

    Research output: Contribution to journalJournal articleResearch

  29. Published

    Role of amino acid oxidation and protein unfolding in peroxyl radical and peroxynitrite-induced inactivation of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides

    Figueroa, J. D., Fuentes Lemus, Eduardo, Reyes, J. S., Loaiza, M., Aliaga, M. E., Fierro, A., Leinisch, F., Hägglund, Per Mårten, Davies, Michael J. & López-Alarcón, C., 2022, In: Free Radical Biology and Medicine. 190, p. 292-306

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Crowding modulates the glycation of plasma proteins: In vitro analysis of structural modifications to albumin and transferrin and identification of sites of modification

    Fuentes Lemus, Eduardo, Reyes, J. S., López-Alarcón, C. & Davies, Michael J., 2022, In: Free Radical Biology and Medicine. 193, p. 551-566 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Oxidative Crosslinking of Peptides and Proteins: Mechanisms of Formation, Detection, Characterization and Quantification

    Fuentes Lemus, Eduardo, Hägglund, Per Mårten, López-Alarcón, C. & Davies, Michael J., 1 Jan 2022, In: Molecules. 27, 1, p. 1-31 15.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published
  33. Published

    Oxidant-mediated modification and cross-linking of beta-2-microglobulin

    Jiang, S., Fuentes Lemus, Eduardo & Davies, Michael J., 2022, In: Free Radical Biology and Medicine. 187, p. 59-71

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Peroxynitrous acid-modified extracellular matrix alters gene and protein expression in human coronary artery smooth muscle cells and induces a pro-inflammatory phenotype

    Jørgensen, S. M., Lorentzen, Lasse Gøbel, Chuang, Christine & Davies, Michael J., 2022, In: Free Radical Biology and Medicine. 186, p. 43-52

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Proteomic Characterization of Atherosclerotic Lesions in Situ Using Percutaneous Coronary Intervention Angioplasty Balloons-Brief Report

    Lorentzen, Lasse Gøbel, Hansen, G. M., Iversen, Kasper, Bundgård, Henning & Davies, Michael J., 2022, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 42, 7, p. 857-864

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Synthesis and cellular evaluation of click-chemistry probes to study the biological effects of alpha, beta-unsaturated carbonyls

    Morozzi, C., Sauerland, M., Gamon, Luke Francis, Manandhar, Asmita, Ulven, Trond & Davies, Michael J., 2022, In: Redox Biology. 52, 8 p., 102299.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

    Murphy, M. P., Bayir, H., Belousov, V., Chang, C. J., Davies, K. J. A., Davies, M. J., Dick, T. P., Finkel, T., Forman, H. J., Janssen-Heininger, Y., Gems, D., Kagan, V. E., Kalyanaraman, B., Larsson, N. G., Milne, G. L., Nyström, T., Poulsen, H. E., Radi, R., Van Remmen, H., Schumacker, P. T. & 5 others, Thornalley, P. J., Toyokuni, S., Winterbourn, C. C., Yin, H. & Halliwell, B., 2022, In: Nature Metabolism. 4, 6, p. 651-662

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC

    Perez-Hernandez, M., van Opbergen, C. J. M., Bagwan, N., Vissing, C. R., Marron-Linares, G. M., Zhang, M., Vega, E. T., Sorrentino, A., Drici, L., Sulek, K., Zhai, R., Hansen, F. B., Christensen, A. H., Boesgaard, S., Gustafsson, F., Rossing, K., Small, E. M., Davies, M. J., Rothenberg, E., Sato, P. Y. & 6 others, Cerrone, M., Jensen, Thomas Hartvig Lindkær, Qvortrup, Klaus, Bundgård, Henning, Delmar, M. & Lundby, Alicia, 2022, In: Circulation. 146, 11, p. 851-867

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Implications of differential peroxyl radical-induced inactivation of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase for the pentose phosphate pathway

    Reyes, J. S., Fuentes Lemus, Eduardo, Figueroa, J. D., Rojas, J., Fierro, A., Arenas, F., Hägglund, Per Mårten, Davies, Michael J. & López-Alarcón, C., 2022, In: Scientific Reports. 12, 1, 19 p., 21191.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Reaction of cysteine residues with oxidized tyrosine residues mediates cross-linking of photo-oxidized casein proteins

    Rossi, C., Fuentes Lemus, Eduardo & Davies, Michael J., 2022, In: Food Chemistry. 385, 7 p., 132667.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Structural Basis for Dityrosine-Mediated Inhibition of alpha-Synuclein Fibrillization

    Sahin, C., Osterlund, E. C., Osterlund, N., Costeira-Paulo, J., Pedersen, J. N., Christiansen, G., Nielsen, J., Grønnemose, A. L., Amstrup, S. K., Tiwari, M. K., Rao, R. S. P., Bjerrum, Morten Jannik, Ilag, L. L., Davies, Michael J., Marklund, E. G., Pedersen, J. S., Landreh, M., Moller, I. M., Jorgensen, T. J. D. & Otzen, D. E., 2022, In: Journal of the American Chemical Society. 144, 27, p. 11949-11954 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Electrophile versus oxidant modification of cysteine residues: Kinetics as a key driver of protein modification

    Sauerland, Max Benjamin & Davies, Michael J., 30 Sep 2022, In: Archives of Biochemistry and Biophysics. 727, 10 p., 109344.

    Research output: Contribution to journalReviewResearchpeer-review

  43. Published

    Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

    Sies, H., Belousov, V. V., Chandel, N. S., Davies, Michael J., Jones, D. P., Mann, G. E., Murphy, M. P., Yamamoto, M. & Winterbourn, C., 2022, In: Nature Reviews Molecular Cell Biology. 23, p. 499–515

    Research output: Contribution to journalReviewResearchpeer-review

  44. Published

    Activation and Inhibition of Human Matrix Metalloproteinase-9 (MMP9) by HOCl, Myeloperoxidase and Chloramines

    Wang, Y., Chuang, Christine, Hawkins, Clare Louise & Davies, Michael J., Aug 2022, In: Antioxidants. 11, 8, 22 p., 1616.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Influence of plasma halide, pseudohalide and nitrite ions on myeloperoxidase-mediated protein and extracellular matrix damage

    Xu, Shuqi, Chuang, Christine, Malle, E., Gamon, Luke Francis, Hawkins, Clare Louise & Davies, Michael J., 2022, In: Free Radical Biology and Medicine. 188, p. 162-174

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. 2021
  47. Published

    The Use of Membrane Filtration to Increase Native Whey Proteins in Infant Formula

    Chen, Y., Callanan, M., Shanahan, C., Tobin, J., Gamon, Luke Francis, Davies, Michael J., Giblin, L. & Brodkorb, A., Sep 2021, In: Dairy. 2, 4, p. 515-529

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Anthocyanin complex niosome gel accelerates oral wound healing: In vitro and clinical studies

    Damrongrungruang, T., Paphangkorakit, J., Limsitthichaikoon, S., Khampaenjiraroch, B., Davies, Michael J., Sungthong, B. & Priprem, A., 2021, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 37, 14 p., 102423.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    "What, where and how much? Key challenges in protein oxidation"

    Davies, Michael J., 2021, In: Free Radical Biology and Medicine. 165, Suppl. 1, p. 15-15 Suppl. 13-1.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  50. Published

    Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases

    Davies, Michael J., 2021, In: Pharmacology and Therapeutics. 218, 23 p., 107685.

    Research output: Contribution to journalReviewResearchpeer-review

  51. Published

    Reactivity of Peroxidase-Derived Oxidants with Proteins, Glycoproteins and Proteoglycans

    Davies, Michael J., 1 Jan 2021, Mammalian Heme Peroxidases: Diverse Roles in Health and Disease. CRC Press, p. 53-77

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  52. Published

    Modulation of hypochlorous acid (HOCl) induced damage to vascular smooth muscle cells by thiocyanate and selenium analogues

    Flouda, K., Gammelgaard, Bente, Davies, Michael J. & Hawkins, Clare Louise, May 2021, In: Redox Biology. 41, 101873.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage

    Flouda, K., Mercer, J., Davies, Michael J. & Hawkins, Clare Louise, 2021, In: Free Radical Biology & Medicine. 166, p. 165-177

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Effect of macromolecular crowding on protein oxidation: Consequences on the rate, extent and oxidation pathways

    Fuentes Lemus, Eduardo, Reyes, J. S., Gamon, Luke Francis, López-Alarcón, C. & Davies, Michael J., 2021, In: Redox Biology. 48, 15 p., 102202.

    Research output: Contribution to journalJournal articleResearchpeer-review

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