Maiken Nedergaard
Professor
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A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone
Ribeiro Xavier, A. L., Kress, B. T., Goldman, Steven Alan, Lacerda de Menezes, J. R. & Nedergaard, Maiken, 26 Aug 2015, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35, 34, p. 11848-11861 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A SPECT-based method for dynamic imaging of the glymphatic system in rats
Sigurdsson, B., Hauglund, Natalie Linea, Lilius, T. O., Mogensen, F. L. H., Mortensen, K. N., Beschorner, Natalie, Klinger, L., Bærentzen, S. L., Rosenholm, Marko, Shalgunov, Vladimir, Herth, Matthias Manfred, Mori, Yuki & Nedergaard, Maiken, 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 7, 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A mesothelium divides the subarachnoid space into functional compartments
Møllgård, Kjeld, Beinlich, Felix Ralf Michael, Kusk, P., Miyakoshi, L. M., Delle, Christine, Pla Requena, Virginia Teresa, Hauglund, Natalie Linea, Esmail, Tina, Rasmussen, Martin Kaag, Gomolka, Ryszard Stefan, Mori, Yuki & Nedergaard, Maiken, 2023, In: Science. 379, 6627, p. 84-885Research output: Contribution to journal › Journal article › Research › peer-review
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A network model of glymphatic flow under different experimentally-motivated parametric scenarios
Tithof, J., Boster, K. A. S., Bork, Peter Aleksander Rousing, Nedergaard, Maiken, Thomas, J. H. & Kelley, D. H., 2022, In: iScience. 25, 5, 24 p., 104258.Research output: Contribution to journal › Journal article › Research › peer-review
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A real-time in vivo clearance assay for quantification of glymphatic efflux
Plá, V., Bork, Peter Aleksander Rousing, Harnpramukkul, A., Olveda, G., Ladrón-de-Guevara, A., Giannetto, M. J., Hussain, R., Wang, W., Kelley, D. H., Hablitz, L. M. & Nedergaard, Maiken, 2022, In: Cell Reports. 40, 11, 20 p., 111320.Research output: Contribution to journal › Journal article › Research › peer-review
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A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life
Wu, S-Y., Wen, Y., Serre, N. B. C., Laursen, C. C. H., Dietz, A. G., Taylor, B. R., Drobizhev, M., Molina, R. S., Aggarwal, A., Rancic, V., Becker, M., Ballanyi, K., Podgorski, K., Hirase, H., Nedergaard, M., Fendrych, M., Lemieux, M. J., Eberl, D. F., Kay, A. R., Campbell, R. E. & 1 others, , 2023, In: PLOS Biology. 20, 9, 23 p., e3001772.Research output: Contribution to journal › Journal article › Research › peer-review
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A three-dimensional, population-based average of the C57BL/6 mouse brain from DAPI-stained coronal slices
Stæger, Frederik Filip Vinggaard, Mortensen, K. N., Nielsen, M. S. N., Sigurdsson, B., Kaufmann, L. K., Hirase, Hajime & Nedergaard, Maiken, 2020, In: Scientific Data. 7, 1, 7 p., 235.Research output: Contribution to journal › Journal article › Research › peer-review
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AMELIORATION OF GLYMPHATIC PATHWAY IS CRITICAL FOR LONG TERM RECOVERY FROM TRAUMATIC BRAIN INJURY
Hussain, R., Wang, W., Cheetham-West, A. O., Sun, Q. & Nedergaard, Maiken, 2018, p. A204. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
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Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization
Monai, H., Koketsu, S., Shinohara, Y., Ueki, T., Kusk, P., Hauglund, Natalie Linea, Samson, A. J., Nedergaard, Maiken & Hirase, Hajime, 2021, In: Scientific Reports. 11, 1, 8150.Research output: Contribution to journal › Journal article › Research › peer-review
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Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke
Monai, H., Wang, X., Yahagi, K., Lou, N., Mestre, H., Xu, Q., Abe, Y., Yasui, M., Iwai, Y., Nedergaard, Maiken & Hirase, Hajime, 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 22, p. 11010-11019 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Age- and glaucoma-induced changes to the ocular glymphatic system
Wang, X., Delle, Christine, Peng, W., Pla Requena, Virginia Teresa, Giannetto, M., Kusk, P., Sigurdsson, B., Sakurai, S., Sweeney, A., Sun, Q., Du, Ting, Libby, R. T. & Nedergaard, Maiken, 2023, In: Neurobiology of Disease. 188, 9 p., 106322.Research output: Contribution to journal › Journal article › Research › peer-review
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Air pollution, glymphatic impairment, and Alzheimer's disease
Hussain, R., Graham, U., Elder, A. & Nedergaard, Maiken, 2023, In: Trends in Neurosciences. 46, 11, p. 901-911 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Altered physiological brain variation in drug-resistant epilepsy
Kananen, J., Tuovinen, T., Ansakorpi, H., Rytky, S., Helakari, H., Huotari, N., Raitamaa, L., Raatikainen, V., Rasila, A., Borchardt, V., Korhonen, V., LeVan, P., Nedergaard, Maiken & Kiviniemi, V., 2018, In: Brain and Behavior. 8, 9, p. 1-17 17 p., e01090.Research output: Contribution to journal › Journal article › Research › peer-review
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An ocular glymphatic clearance system removes beta-amyloid from the rodent eye
Wang, X., Lou, N., Eberhardt, A., Yang, Y., Kusk, P., Xu, Q., Forstera, B., Peng, S., Shi, M., Ladron-de-Guevara, A., Delle, Christine, Sigurdsson, B., L R Xavier, Anna , Erturk, A., Libby, R. T., Chen, L., Thrane, A. S. & Nedergaard, Maiken, 2020, In: Science Translational Medicine. 12, 536, eaaw3210.Research output: Contribution to journal › Journal article › Research › peer-review
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An unnoticed player overseeing CSF flux
Pla Requena, Virginia Teresa & Nedergaard, Maiken, 2022, In: Nature Cardiovascular Research. 1, 2 p.Research output: Contribution to journal › Comment/debate › Research
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Aquaporin 1 and the Na+/K+/2Cl- cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system
Li, Q., Aalling, Nadia, Förstera, B., Ertürk, A., Nedergaard, Maiken, Møllgård, Kjeld & L R Xavier, Anna , 2020, In: Fluids and Barriers of the CNS. 17, 15 p., 15.Research output: Contribution to journal › Journal article › Research › peer-review
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Aquaporin-4-dependent glymphatic solute transport in the rodent brain
Mestre, H., Hablitz, L. M., Xavier, A. L. R., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Rivera, R. M. C., Simon, M. J., Pike, M. M., Pla, V., Du, T., Kress, B. T., Wang, X., Plog, B. A., Thrane, A. S., Lundgaard, I., Abe, Y., Yasui, M. & 6 others, , 2018, In: eLife. 7, 31 p., :e40070.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow
Bork, Peter Aleksander Rousing, Ladrón-De-Guevara, A., Christensen, A. H., Jensen, K. H., Nedergaard, Maiken & Bohr, T., 2023, In: Journal of the Royal Society Interface. 20, 204, 5 p., 20230050.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytes in chronic pain and itch
Ji, R., Donnelly, C. R. & Nedergaard, Maiken, 2019, In: Nature Reviews Neuroscience. 20, 11, p. 667-685Research output: Contribution to journal › Review › Research › peer-review
Astrocytic Endocannabinoids Mediate Hippocampal Transient Heterosynaptic Depression
Smith, N. A., Bekar, L. K. & Nedergaard, Maiken, 2020, In: Neurochemical Research. 45, 1, p. 100-108 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes
Ozawa, K., Nagao, Masaki, Konno, A., Iwai, Y., Vittani, Marta, Kusk, P., Mishima, Tsuneko, Hirai, H., Nedergaard, Maiken & Hirase, Hajime, 2023, In: International Journal of Molecular Sciences. 24, 17, 12 p., 13590.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice
Untiet, Verena, Beinlich, Felix Ralf Michael, Kusk, P., Kang, N., Ladrón-de-Guevara, A., Song, W., Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Bojarowska, Zuzanna, Sigurdsson, B., Deng, S., Hirase, Hajime, Petersen, Nicolas Caesar, Verkhratsky, A. & Nedergaard, Maiken, 2023, In: Nature Communications. 14, 1, 14 p., 1871.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease
Wang, M., Qin, C., Luo, X., Wang, J., Wang, X., Xie, M., Hu, J., Cao, J., Hu, T., Goldman, Steven Alan, Nedergaard, Maiken & Wang, W., 2019, In: Theranostics. 9, 15, p. 4474-4493 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function
Lundgaard, I., Wang, W., Eberhardt, A., Vinitsky, H. S., Reeves, B. C., Peng, S., Lou, N., Hussain, R. & Nedergaard, Maiken, 2018, In: Scientific Reports. 8, 1, 16 p., 2246.Research output: Contribution to journal › Journal article › Research › peer-review
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Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice
Giannetto, M., Xia, M., Stæger, Frederik Filip Vinggaard, Metcalfe, T., Vinitsky, H. S., Dang, J. A. M. L., L R Xavier, Anna , Kress, B. T., Nedergaard, Maiken & Hablitz, L. M., 2020, In: Scientific Reports. 10, 1, 8 p., 16073.Research output: Contribution to journal › Journal article › Research › peer-review
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Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer’s disease in hypertension
Beaman, Emily Eufaula, Bonde, A. N., Larsen, S. M. U., Ozenne, Brice Maxime Hugues, Lohela, T. J., Nedergaard, Maiken, Gislason, Gunnar Hilmar, Knudsen, Gitte Moos & Holst, S. C., 2023, In: Brain. 146, 3, p. 1141–1151 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI
Koundal, S., Liu, X., Sanggaard, S., Mortensen, K., Wardlaw, J., Nedergaard, Maiken, Benveniste, H. & Lee, H., 2019, In: Neuroscience. 404, p. 14-26Research output: Contribution to journal › Journal article › Research › peer-review
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Brain Segmentation in Rodent MR-Images Using Convolutional Neural Networks
Sigurdsson, B., Darkner, Sune, Sommer, Stefan Horst, Mortensen, K. N., Sanggaard, S., Kostrikov, S. & Nedergaard, Maiken, 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Brain energetics during the sleep-wake cycle
DiNuzzo, M. & Nedergaard, Maiken, Dec 2017, In: Current Opinion in Neurobiology. 47, p. 65-72 8 p.Research output: Contribution to journal › Review › Research › peer-review
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Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection
Raghunandan, A., Ladron-De-guevara, A., Tithof, J., Mestre, H., Du, T., Nedergaard, Maiken, Thomas, J. H. & Kelley, D. H., 2021, In: eLife. 10, 15 p., e65958.Research output: Contribution to journal › Journal article › Research › peer-review
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CSF space volumetry using 3D-CISS in Aqp4-deficient mice – quantitative analysis and technical advances
Gomolka, Ryszard Stefan, Nedergaard, Maiken & Mori, Yuki, 2021, Book of Abstracts ESMRMB 2021 Online 38th Annual Scientific Meeting 7-9 October 2021. Springer, Vol. 34. p. S95-6 2 p. (Magnetic Resonance Materials in Physics, Biology, and Medicine; No. 34).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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Cannula Implantation into the Cisterna Magna of Rodents
L R Xavier, Anna , Hauglund, Natalie Linea, Holstein-Rønsbo, Stephanie, Li, Q., Sanggaard, S., Lou, N., Lundgaard, I. & Nedergaard, Maiken, 2018, In: Journal of Visualized Experiments. 135, 6 p., e57378.Research output: Contribution to journal › Journal article › Research › peer-review
Cardiovascular brain impulses in Alzheimer's disease
Rajna, Z., Mattila, H., Huotari, N., Tuovinen, T., Krüger, J., Holst, S. C., Korhonen, V., Remes, A. M., Seppänen, T., Hennig, J., Nedergaard, Maiken & Kiviniemi, V., 2021, In: Brain. 144, 7, p. 2214-2226 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas
Grutzendler, J. & Nedergaard, Maiken, 2019, In: Trends in Neurosciences. 42, 8, p. 528-536 9 p.Research output: Contribution to journal › Review › Research › peer-review
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Cerebral Metabolic Changes During Sleep
Aalling, Nadia, Nedergaard, Maiken & DiNuzzo, M., 1 Sep 2018, In: Current Neurology and Neuroscience Reports. 18, 9, 17 p., 57.Research output: Contribution to journal › Review › Research › peer-review
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Cerebral small vessel disease: A glymphopathy?
Benveniste, H. & Nedergaard, Maiken, 2021, In: Current Opinion in Neurobiology. 72, p. 15-21 7 p.Research output: Contribution to journal › Review › Research › peer-review
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Cerebrospinal fluid clearance in Alzheimer disease measured with dynamic PET
De Leon, M. J., Li, Y., Okamura, N., Tsui, W. H., Saint-Louis, L. A., Glodzik, L., Osorio, R. S., Fortea, J., Butler, T., Pirraglia, E., Fossati, S., Kim, H. J., Carare, R. O., Nedergaard, Maiken, Benveniste, H. & Rusinek, H., 2017, In: Journal of Nuclear Medicine. 58, 9, p. 1471-1476 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cerebrospinal fluid influx drives acute ischemic tissue swelling
Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Stæger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P., Kleinfeld, D. & 3 others, , 2020, In: Science. 367, 6483, 8 p., eaaw7462.Research output: Contribution to journal › Journal article › Research › peer-review
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Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema
Du, T., Mestre, H., Kress, B. T., Liu, G., Sweeney, A. M., Samson, A. J., Rasmussen, M. K., Mortensen, K. N., Bork, P. A. R., Peng, W., Olveda, G. E., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Hirase, H. & 2 others, , 2022, In: Brain. 145, 2, p. 787–797 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in the composition of brain interstitial ions control the sleep-wake cycle
Ding, F., O'Donnell, J., Xu, Q., Kang, N., Goldman, N. & Nedergaard, Maiken, 29 Apr 2016, In: Science. 352, 6285, p. 550-555 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in visual processing during progression of Tau accumulation and neurodegeneration in a mouse model of human tauopathy
Parka, A., Nedergaard, Maiken, Sotty, F. & Laursen, B., 2021, In: Investigative Ophthalmology & Visual Science. 62, 8, 3 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Circadian control of brain glymphatic and lymphatic fluid flow
Hablitz, L. M., Plá, V., Giannetto, M., Vinitsky, H. S., Stæger, Frederik Filip Vinggaard, Metcalfe, T., Nguyen, R., Benrais, A. & Nedergaard, Maiken, 2020, In: Nature Communications. 11, 1, 4411.Research output: Contribution to journal › Journal article › Research › peer-review
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Cisterna magna injection in rats to study glymphatic function
Ramos, M., Burdon Bechet, N., Battistella, R., Pavan, C., L R Xavier, Anna , Nedergaard, Maiken & Lundgaard, I., 2019, Astrocytes: Methods and Protocols. Di Benedetto, B. (ed.). Humana Press, p. 97-104 8 p. (Methods in Molecular Biology, Vol. 1938).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Cleaning the sleeping brain – the potential restorative function of the glymphatic system
Hauglund, Natalie Linea, Pavan, C. & Nedergaard, Maiken, 1 Jun 2020, In: Current Opinion in Physiology. 15, 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses
Larsen, B. R., Assentoft, M., Cotrina, M. L., Hua, S. Z., Nedergaard, Maiken, Kaila, K., Voipio, J. & MacAulay, Nanna, Apr 2014, In: Glia. 62, 4, p. 608-22 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice
Rasmussen, R., Nicholas, E., Petersen, Nicolas Caesar, Dietz, Andrea Grostøl, Xu, Q., Sun, Q. & Nedergaard, Maiken, 2019, In: Cell Reports. 28, 5, p. 1182-1194 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Could dexmedetomidine be repurposed as a glymphatic enhancer?
Persson, N. D. Å., Uusalo, P., Nedergaard, Maiken, Lohela, T. J. & Lilius, T. O., 2022, In: Trends in Pharmacological Sciences. 43, 12, p. 1030-1040 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “ISMRM Imaging Neurofluids Study group” Workshop in Rome
Agarwal, N., Lewis, L. D., Hirschler, L., Rivera, L. R., Naganawa, S., Levendovszky, S. R., Ringstad, G., Klarica, M., Wardlaw, J., Iadecola, C., Hawkes, C., Carare, R. O., Wells, J., Bakker, E. N. T. P., Kurtcuoglu, V., Bilston, L., Nedergaard, M., Mori, Y., Stoodley, M., Alperin, N. & 2 others, , 2024, In: Journal of Magnetic Resonance Imaging. 59, 2, 19 p.Research output: Contribution to journal › Review › Research › peer-review
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DNase treatment prevents CSF block in early experimental pneumococcal meningitis
Pavan, C., L R Xavier, Anna , Ramos, M., Fisher, J., Kritsilis, M., Linder, A., Bentzer, P., Nedergaard, Maiken & Lundgaard, I., 2021, In: Annals of Neurology. 90, 4, p. 653-669 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Defining novel functions for cerebrospinal fluid in ALS pathophysiology
Ng Kee Kwong, K. C., Mehta, A. R., Nedergaard, Maiken & Chandran, S., 2020, In: Acta Neuropathologica Communications. 8, 1, 18 p.Research output: Contribution to journal › Review › Research › peer-review
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Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice
Mathiesen, B. K., Miyakoshi, L. M., Cederroth, C. R., Tserga, E., Versteegh, C., Bork, Peter Aleksander Rousing, Hauglund, Natalie Linea, Gomolka, Ryszard Stefan, Mori, Yuki, Edvall, N. K., Rouse, S., Møllgård, Kjeld, Holt, J. R., Nedergaard, Maiken & Canlon, B., 2023, In: Science Translational Medicine. 15, 702, 13 p., eabq3916.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of 11C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species
Staudt, Markus, Shalgunov, Vladimir, Nedergaard, Maiken & Herth, Matthias Manfred, 2023, In: Journal of Labelled Compounds and Radiopharmaceuticals. 66, 12, p. 393-399Research output: Contribution to journal › Journal article › Research › peer-review
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Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs
Lilius, T. O., Blomqvist, K., Hauglund, Natalie Linea, Liu, G., Stæger, Frederik Filip Vinggaard, Baerentzen, S., Du, T., Ahlstrom, F., Backman, J. T., Kalso, E. A., Rauhala, P. V. & Nedergaard, Maiken, 2019, In: Journal of Controlled Release. 304, p. 29-38 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct Measurement of Cerebrospinal Fluid Production in Mice
Liu, G., Mestre, H., Sweeney, A. M., Sun, Q., Weikop, Pia, Du, T. & Nedergaard, Maiken, 2020, In: Cell Reports. 33, 12, 13 p., 108524.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct neuronal glucose uptake Heralds activity-dependent increases in cerebral metabolism
Lundgaard, I., Li, B., Xie, L., Kang, H., Sanggaard, S., Haswell, J. D. R., Sun, W., Goldman, S., Blekot, S., Nielsen, Michael Lund, Takano, T., Deane, R. & Nedergaard, Maiken, 2015, In: Nature Communications. 6, 12 p., 6807.Research output: Contribution to journal › Journal article › Research › peer-review
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Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain?
Oberheim Bush, N. A. & Nedergaard, Maiken, Sep 2017, In: Neurochemical Research. 42, 9, p. 2577-2587 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?
Kjærby, Celia, Rasmussen, R., Andersen, Mie & Nedergaard, Maiken, Jun 2017, In: Neurochemical Research. 42, 6, p. 1810-1822 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?
Wostyn, P., Mader, T. H., Gibson, C. R. & Nedergaard, Maiken, 2022, In: Eye and Brain. 14, p. 49-58 10 p.Research output: Contribution to journal › Review › Research › peer-review
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Dynamic fluctuations of the locus coeruleus-norepinephrine system underlie sleep state transitions
Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Ding, F., Wang, W., Xu, Q., Deng, S., Kang, N., Peng, S., Sun, Q., Dall, C., Jørgensen, P. K., Feng, J., Li, Y., Weikop, Pia, Hirase, Hajime & Nedergaard, Maiken, 2 Sep 2020, 1 p.Research output: Other contribution › Research
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Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling
Liu, Z., Osipovitch, M., Benraiss, A., Huynh, N. P. T., Foti, R., Bates, J., Chandler-Militello, D., Findling, R. L., Tesar, P. J., Nedergaard, Maiken, Windrem, M. S. & Goldman, Steven Alan, 2019, In: Cell Reports. 27, 13, p. 3832-3843, e1-e6Research output: Contribution to journal › Journal article › Research › peer-review
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EARLY ADDRESS OF POST-TRAUMATIC GLYMPHATIC INSUFFICIENCY REDUCES NEURONAL/GLIAL CELL DEATH AND TISSUE DAMAGES
Hussain, R., Wang, W. & Nedergaard, Maiken, 2019, In: Journal of Neurotrauma. 36, 13, p. A-101 1 p., B04-05.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model
Parka, A., Degel, C., Dreyer, J., Richter, U., Hall, B., Bastlund, J. F., Laursen, B., Nedergaard, Maiken, Sotty, F. & Botta, P., 2023, In: Neurobiology of Disease. 178, 13 p., 106012.Research output: Contribution to journal › Journal article › Research › peer-review
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Editorial: Sleep and Mood Disorders
Verkhratsky, A., Nedergaard, Maiken, Steardo, L. & Li, B., 2020, In: Frontiers in Psychiatry. 10, 3 p., 981.Research output: Contribution to journal › Editorial › Research › peer-review
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Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation
Wei, H. S., Kang, H., Rasheed, I. D., Zhou, S., Lou, N., Gershteyn, A., McConnell, E. D., Wang, Y., Richardson, K. E., Palmer, A. F., Xu, C., Wan, J. & Nedergaard, Maiken, 17 Aug 2016, In: Neuron. 91, 4, p. 851-862 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
Mestre, H., Tithof, J., Du, T., Song, W., Peng, W., Sweeney, A. M., Olveda, G., Thomas, J. H., Nedergaard, Maiken & Kelley, D. H., 2018, In: Nature Communications. 9, 1, 9 p., 4878.Research output: Contribution to journal › Journal article › Research › peer-review
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Fluid Transport in the Brain
Rasmussen, Martin Kaag, Mestre, H. & Nedergaard, Maiken, 2022, In: Physiological Reviews. 102, p. 1025-1151 27 p.Research output: Contribution to journal › Review › Research › peer-review
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Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts
Wang, M., Ding, F., Deng, S., Guo, X., Wang, W., Iliff, J. J. & Nedergaard, Maiken, 15 Mar 2017, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 37, 11, p. 2870-2877 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic haplotype of the glymphatic-associated water channel aquaporin 4 modulates slow waves in human non-rapid eye movement sleep
Larsen, S. M. U., Landolt, H. P., Berger, W., Nedergaard, Maiken, Knudsen, Gitte Moos & Holst, S. C., 2019, In: European Neuropsychopharmacology. 29, Supplement 6, p. S563-S564 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Glial cells in schizophrenia: a unified hypothesis
Dietz, Andrea Grostøl, Goldman, Steven Alan & Nedergaard, Maiken, 2020, In: Lancet Psychiatry. 7, 3, p. 272-281 10 p.Research output: Contribution to journal › Review › Research › peer-review
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Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus
Reeves, B. C., Karimy, J. K., Kundishora, A. J., Mestre, H., Cerci, H. M., Matouk, C., Alper, S. L., Lundgaard, I., Nedergaard, Maiken & Kahle, K. T., 2020, In: Trends in Molecular Medicine. 26, 3, p. 285-295 11 p.Research output: Contribution to journal › Review › Research › peer-review
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Glymphatic clearance controls state-dependent changes in brain lactate concentration
Lundgaard, I., Lu, M. L., Yang, E., Peng, W., Mestre, H., Hitomi, E., Deane, R. & Nedergaard, Maiken, Jun 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 6, p. 2112-2124 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glymphatic failure as a final common pathway to dementia
Nedergaard, Maiken & Goldman, Steven Alan, 2020, In: Science (New York, N.Y.). 370, 6512, p. 50-56 7 p.Research output: Contribution to journal › Review › Research › peer-review
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Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271
Giannetto, M. J., Gomolka, Ryszard Stefan, Gahn-Martinez, D., Newbold, E. J., Bork, Peter Aleksander Rousing, Chang, E., Gresser, M., Thompson, T., Mori, Yuki & Nedergaard, Maiken, 2024, In: Glia. 72, 5, p. 982-998 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glymphatic influx and clearance are accelerated by neurovascular coupling: [Inkl. Correction]
Holstein-Rønsbo, Stephanie, Gan, Y., Giannetto, M. J., Rasmussen, Martin Kaag, Sigurdsson, B., Beinlich, Felix Ralf Michael, Rose, Laura, Untiet, Verena, Hablitz, L. M., Kelley, D. H. & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, p. 1042–1053Research output: Contribution to journal › Journal article › Research › peer-review
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Glymphatic system
Benveniste, H. & Nedergaard, Maiken, 2016, Neuroscience in the 21st Century: From Basic to Clinical. 2 ed. Springer, p. 1945-1962 18 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Glymphatic system and Spaceflight Associated Neuro-Ocular Syndrome
Wostyn, P. & Nedergaard, Maiken, 2022, Spaceflight Associated Neuro-Ocular Syndrome. Elsevier, p. 67-76 10 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Glymphatic system dysfunction in neurodegenerative diseases
Beschorner, Natalie & Nedergaard, Maiken, 2024, In: Current Opinion in Neurology. 37, 2, p. 182-188 7 p.Research output: Contribution to journal › Review › Research › peer-review
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Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles
Lilius, T. O., Mortensen, K. N., Deville, C., Lohela, T. J., Stæger, Frederik Filip Vinggaard, Sigurdsson, B., Fiordaliso, E. M., Rosenholm, Marko, Kamphuis, C., Beekman, F. J., Jensen, A. I. & Nedergaard, Maiken, 2023, In: Journal of Controlled Release. 355, p. 135-148 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep
Larsen, S. M. U., Landolt, H. P., Berger, W., Nedergaard, Maiken, Knudsen, Gitte Moos & Holst, S. C., May 2020, In: PLOS Biology. 18, 5, 14 p., e3000623.Research output: Contribution to journal › Journal article › Research › peer-review
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Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain
Windrem, M. S., Schanz, S. J., Zou, L., Chandler-Militello, D., Kuypers, N. J., Nedergaard, Maiken, Lu, Y., Mariani, J. N. & Goldman, Steven Alan, 2020, In: Cell Reports. 31, 7, 23 p., 107658.Research output: Contribution to journal › Journal article › Research › peer-review
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Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations
Helakari, H., Korhonen, V., Holst, S. C., Piispala, J., Kallio, M., Väyrynen, T., Huotari, N., Raitamaa, L., Tuunanen, J., Kananen, J., Järvelä, M., Tuovinen, T., Raatikainen, V., Borchardt, V., Kinnunen, H., Nedergaard, Maiken & Kiviniemi, V., 2022, In: Journal of Neuroscience. 42, 12, p. 2503-2515 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Human glia can both induce and rescue aspects of disease phenotype in Huntington disease
Benraiss, A., Wang, S., Herrlinger, S., Li, X., Chandler-Militello, D., Mauceri, J., Burm, H. B., Toner, M., Osipovitch, M., Jim Xu, Q., Ding, F., Wang, F., Kang, N., Kang, J., Curtin, P. C., Brunner, D., Windrem, M. S., Munoz-Sanjuan, I., Nedergaard, Maiken & Goldman, Steven Alan, 7 Jun 2016, In: Nature Communications. 7, 13 p., 11758.Research output: Contribution to journal › Journal article › Research › peer-review
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Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia
Windrem, M. S., Osipovitch, M., Liu, Z., Bates, J., Chandler-Militello, D., Zou, L., Munir, J., Schanz, S., McCoy, K., Miller, R. H., Wang, S., Nedergaard, Maiken, Findling, R. L., Tesar, P. J. & Goldman, Steven Alan, 3 Aug 2017, In: Cell Stem Cell. 21, 2, p. 195-208.e6Research output: Contribution to journal › Journal article › Research › peer-review
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Impaired Glymphatic Transport in Spontaneously Hypertensive Rats
Nygaard Mortensen, K., Sanggaard, S., Mestre, H., Lee, H., Kostrikov, S., L R Xavier, Anna , Gjedde, Albert, Benveniste, H. & Nedergaard, Maiken, 2019, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 32, p. 6365-6377 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impairment of the glymphatic system after diabetes
Jiang, Q., Zhang, L., Ding, G., Davoodi-Bojd, E., Li, Q., Li, L., Sadry, N., Nedergaard, Maiken, Chopp, M. & Zhang, Z., 1 Apr 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 4, p. 1326-1337 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Implications of the discovery of brain lymphatic pathways
Iliff, J. J., Goldman, Steven Alan & Nedergaard, Maiken, 2015, In: Lancet Neurology. 14, 10, p. 977-979 3 p.Research output: Contribution to journal › Journal article › Communication
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In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
Sweeney, A. M., Pla, V., Du, T., Liu, G., Sun, Q., Peng, S., Plog, B. A., Kress, B. T., Wang, X., Mestre, H. & Nedergaard, Maiken, 2019, In: Journal of Visualized Experiments. 149, 7 p., e59774.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia
Hablitz, L. M., Vinitsky, H. S., Sun, Q., Stæger, Frederik Filip Vinggaard, Sigurdsson, B., Mortensen, K. N., Lilius, T. O. & Nedergaard, Maiken, 2019, In: Science Advances. 5, 2, 9 p., eaav5447.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased interictal synchronicity of respiratory related brain pulsations in epilepsy
Kananen, J., Järvelä, M., Korhonen, V., Tuovinen, T., Huotari, N., Raitamaa, L., Helakari, H., Väyrynen, T., Raatikainen, V., Nedergaard, Maiken, Ansakorpi, H., Jacobs, J., LeVan, P. & Kiviniemi, V., 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 10, p. 1840-1853 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets
Karimy, J. K., Reeves, B. C., Damisah, E., Duy, P. Q., Antwi, P., David, W., Wang, K., Schiff, S. J., Limbrick, D. D. ,. J., Alper, S. L., Warf, B. C., Nedergaard, Maiken, Simard, J. M. & Kahle, K. T., 2020, In: Nature Reviews Neurology. 16, p. 285–296 12 p.Research output: Contribution to journal › Review › Research › peer-review
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Interstitial ions: A key regulator of state-dependent neural activity?
Rasmussen, R., O'Donnell, J., Ding, F. & Nedergaard, Maiken, 2020, In: Progress in Neurobiology. 98, 101802.Research output: Contribution to journal › Review › Research › peer-review
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Inverse correlation of fluctuations of cerebral blood and water concentrations in humans
Borchardt, V., Korhonen, V., Helakari, H., Nedergaard, Maiken, Myllylä, T. & Kiviniemi, V., 2021, In: European Physical Journal Plus. 136, 5, 497.Research output: Contribution to journal › Journal article › Research › peer-review
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Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging
Nasu, Y., Aggarwal, A., Le, G. N. T., Vo, C. T., Kambe, Y., Wang, X., Beinlich, F. R. M., Lee, A. B., Ram, T. R., Wang, F., Gorzo, K. A., Kamijo, Y., Boisvert, M., Nishinami, S., Kawamura, G., Ozawa, T., Toda, H., Gordon, G. R., Ge, S., Hirase, H. & 5 others, , 2023, In: Nature Communications. 14, 1, 17 p., 6598.Research output: Contribution to journal › Journal article › Research › peer-review
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Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation
Wang, Xiaowen, Delle, Christine, Asiminas, Antonios, Akther, S., Vittani, Marta, Brøgger, Peter, Kusk, P., Vo, C. T., Radovanovic, Tessa, Konno, A., Hirai, H., Fukuda, M., Weikop, Pia, Goldman, Steven Alan, Nedergaard, Maiken & Hirase, Hajime, 2022, In: Cell Reports Methods. 2, 10, 16 p., 100302.Research output: Contribution to journal › Journal article › Research › peer-review
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Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output
Dietz, Andrea Grostøl, Weikop, Pia, Hauglund, Natalie Linea, Andersen, Mie, Petersen, Nicolas Caesar, Rose, Laura, Hirase, Hajime & Nedergaard, Maiken, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 40, 9 p., e2305071120.Research output: Contribution to journal › Journal article › Research › peer-review
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Locomotion Induces Fundamentally Different Patterns of Ca2+Signaling in Astrocytes and Neurons
Hirase, Hajime & Nedergaard, Maiken, 2023, In: Function. 4, 4, 2 p., zqad028.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice
Delle, Christine, Cankar, Neza, Digebjerg Holgersson, C., Hvorup Knudsen, H., Nielsen, Elise Schiøler, Kjærby, Celia, Mori, Yuki, Nedergaard, Maiken & Weikop, Pia, 2023, In: Scientific Reports. 13, 1, 11 p., 4137.Research output: Contribution to journal › Journal article › Research › peer-review
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Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
Gomolka, Ryszard Stefan, Hablitz, L. M., Mestre, H., Giannetto, M., Du, Ting, Hauglund, Natalie Linea, Xie, L., Peng, W., Martinez, P. M., Nedergaard, Maiken & Mori, Yuki, 2023, In: eLife. 12, 36 p., e82232.Research output: Contribution to journal › Journal article › Research › peer-review
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Mapping of CSF transport using high spatiotemporal resolution dynamic contrast-enhanced MRI in mice: Effect of anesthesia
Stanton, E. H., Persson, N. D. Å., Gomolka, Ryszard Stefan, Lilius, T., Sigurðsson, B., Lee, H., L R Xavier, Anna , Benveniste, H., Nedergaard, Maiken & Mori, Yuki, 2021, In: Magnetic Resonance in Medicine. 85, 6, p. 3326-3342 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies
Liu, G., Ladrón-de-Guevara, A., Izhiman, Y., Nedergaard, Maiken & Du, Ting, 2022, In: Fluids and Barriers of the CNS. 19, 1, 24 p., 101.Research output: Contribution to journal › Review › Research › peer-review
ID: 101366876
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SPECT imaging of the glymphatic pathway with In-111-labeled ovalbumin in the rat brain
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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470
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In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy
Research output: Contribution to journal › Journal article › Research › peer-review
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339
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Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
Research output: Contribution to journal › Review › Research › peer-review
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