Drug Delivery and Biophysics of Biopharmaceuticals
13, Building: 13-4-417
2100 København Ø
Mai Bay Stie is currently a PhD fellow at the Department of Farmacy at Copenhagen University. She is holding a master's degree in Biochemistry and Molecular Biology from University of Southern Denmark.
The project is entitled "Saliva-repellent, mucoadhesive nanofiber-based hybrid systems for sublingual delivery of biopharmaceuticals". An increasing number of pharmaceuticals are based on molecules of biological origin such as proteins and peptides. These molecules, partly due to the complex nature, often have poor phycial and chemical stabilty in addition to low membrane permeability. The primary route of administration is therefore via injections. Hence, there is a need for a new drug delivery platform to aid the delivery of biopharmaceuticals into the bloodstream. The goal of the project is to form a new drug delivery platform targeting the sublingual mucosa. The hypothesis, on which the project is based, is that the bioadvailability of the loaded biopharmaceutical will increase by forming a hybrid system consisting of i) a saliva repellent film, ii) drug loaded electrospun nanofibers, and iii) other compenents to aid the transmucosal delivery. The aim of the project is to develope and evaluate the preformance of the proposed drug delivery platform.