Lasse Saaby
Affiliated Associate Professor
CNS Drug Delivery and Barrier Modelling
Universitetsparken 2
2100 København Ø
- 2022
- Published
Barrier properties of ex vivo porcine intestinal mucus are highly independent of isolation and storage conditions
Mortensen, Janni Støvring, Saaby, Lasse, Rønholt, Stine & Nielsen, Hanne Mørck, 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 174, p. 106-110Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insight Into the Anti-staphylococcal Activity of JBC 1847 at Sub-Inhibitory Concentration
Ronco, T., Kappel, L. H., Aragao, M. F., Biagi, N., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad, Permin, A., Saaby, Lasse, Holmstrøm, K., Klitgaard, J. K., Sabat, A. J., Akkerboom, V., Monaco, M., Tinelli, M., Friedrich, A. W., Jana, B. & Olsen, Rikke Heidemann, 2022, In: Frontiers in Microbiology. 12, 786173.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)
Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease
Pultz, I. S., Hill, M., Vitanza, J. M., Wolf, C., Saaby, Lasse, Liu, T., Winkle, P. & Leffler, D. A., Jul 2021, In: Gastroenterology. 161, 1, p. 81-93.e3Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A new phenothiazine derivate is active against Clostridioides difficile and shows low cytotoxicity
Ronco, T., Aragao, F. M., Saaby, Lasse, Christensen, Jørn Bolstad, Permin, A., Williams, Andrew Richard, Thamsborg, Stig Milan & Olsen, Rikke Heidemann, 2021, In: PLoS ONE. 16, 10, 13 p., e0258207.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficacy of a novel antimicrobial hydrogel for eradication of Staphylococcus epidermidis, Staphylococcus aureus and Cutibacterium acnes from preformed biofilm and treatment performance in an in vivo MRSA wound model
Ronco, T., Aragao, M. F., Svenningsen, Søren Wedel, Christensen, Jørn Bolstad, Permin, A., Saaby, Lasse, Bionda, N., Lantz, E. E. & Olsen, Rikke Heidemann, 2021, In: JAC-Antimicrobial Resistance. 3, 3, 7 p., dlab108.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)
Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, Nana Isabella, Ozgür, Burak, Holst, B., Shusta, E., Hall, Vanessa Jane, Saaby, Lasse, Hyttel, P. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice
Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes
Saaby, Lasse, Trasborg, J., Rasmussen, M. A., Holst, B. & Larsen, Birger Brodin, 17 Jul 2020, In: Pharmaceutics. 12, 7, 17 p., 673.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
Ambjørner, Sophie Emilie Blomgren, Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, Lasse, Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, N. & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4863000
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188
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Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
163
downloads
The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
60
downloads
A novel derivative of thioridazine shows low toxicity and efficient activity against gram‐positive pathogens
Research output: Contribution to journal › Journal article › Research › peer-review
Published