Klaus Bønnelykke

Klaus Bønnelykke

Clinical Professor

Member of:

  • Paediatrics


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  1. Published

    17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry

    Flory, J. H., Sleiman, P. M., Christie, J. D., Annaiah, K., Bradfield, J., Kim, C. E., Glessner, J., Imielinski, M., Li, H., Frackelton, E. C., Cuiping, H., Otieno, G., Thomas, K., Smith, R., Glaberson, W., Garris, M., Chiavacci, R., Allen, J., Spergel, J., Grundmeier, R. & 32 others, Grunstein, M., Magnusson, M., Grant, S. F. A., Bønnelykke, Klaus, Bisgaard, H., Hakonarson, H., Flory, J. H., Sleiman, P. M., Christie, J. D., Annaiah, K., Bradfield, J., Kim, C. E., Glessner, J., Imielinski, M., Li, H., Frackelton, E. C., Cuiping, H., Otieno, G., Thomas, K., Smith, R., Glaberson, W., Garris, M., Chiavacci, R., Allen, J., Spergel, J., Grundmeier, R., Grunstein, M., Magnusson, M., Grant, S. F. A., Bønnelykke, K., Bisgaard, H. & Hakonarson, H., 1 Sep 2009, In: Journal of Allergy and Clinical Immunology. 124, 3, p. 605-7 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use

    Farzan, N., Vijverberg, S. J., Hernandez-Pacheco, N., Bel, E. H. D., Berce, V., Bønnelykke, K., Bisgaard, H., Burchard, E. G., Canino, G., Celedón, J. C., Chew, F. T., Chiang, W. C., Cloutier, M. M., Forno, E., Francis, B., Hawcutt, D. B., Herrera-Luis, E., Kabesch, M., Karimi, L., Melén, E. & 19 others, Mukhopadhyay, S., Merid, S. K., Palmer, C. N., Pino-Yanes, M., Pirmohamed, M., Potočnik, U., Repnik, K., Schieck, M., Sevelsted, A., Sio, Y. Y., Smyth, R. L., Soares, P., Söderhäll, C., Tantisira, K. G., Tavendale, R., Tse, S. M., Turner, S., Verhamme, K. M. & Maitland-van der Zee, A., 2018, In: Allergy. 73, 10, p. 2083-2088 6 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  3. Published

    25 Years of translational research in the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC)

    Bisgaard, H., Chawes, Bo Lund Krogsgaard, Stokholm, J., Mikkelsen, M., Schoos, Ann-Marie Malby & Bønnelykke, Klaus, 2023, In: Journal of Allergy and Clinical Immunology. 151, 3, p. 619-633 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    25-hydroxyvitamin D and risk of atopic diseases and infections in early childhood

    Brustad, N., Kim, M., Skov, F., Schoos, Ann-Marie Malby, Stokholm, Jakob, Bønnelykke, Klaus & Chawes, Bo Lund Krogsgaard, 2023, In: Allergy: European Journal of Allergy and Clinical Immunology. 78, 10, p. 2770-2773

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  5. Published

    CDHR3 gene variation and childhood bronchiolitis

    Husby, A., Pasanen, A., Waage, J., Sevelsted, A., Hodemaekers, H., Janssen, R., Karjalainen, M. K., Stokholm, Jakob, Chawes, Bo Lund Krogsgaard, Korppi, M., Wennergren, G., Heinzmann, A., Bont, L., Bisgaard, H. & Bønnelykke, Klaus, Nov 2017, In: The Journal of allergy and clinical immunology. 140, 5, p. 1469-1471.e7

    Research output: Contribution to journal › Letter › Research › peer-review

  6. Published

    FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Ahluwalia, T. S., Eliasen, A. U., Sevelsted, A., Pedersen, C-E. T., Stokholm, J., Chawes, B., Bork-Jensen, J., Grarup, N., Pedersen, O., Hansen, T., Linneberg, A., Sharma, A., Weiss, S. T., Evans, M. D., Jackson, D. J., Morin, A., Krogfelt, K. A., Schjørring, S., Mortensen, P. B., Hougaard, D. M. & 13 others, Bybjerg-Grauholm, J., Bækvad-Hansen, M., Mors, O., Nordentoft, Merete, Børglum, A. D., Werge, Thomas, Agerbo, E., Gern, J. E., Lemanske, R. F., Ober, C., Pedersen, A. G., Bisgaard, H. & Bønnelykke, Klaus, 2020, In: Nature Communications. 11, 12 p., 6398.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    NKG2D gene variation and susceptibility to viral bronchiolitis in childhood

    Pasanen, A., Karjalainen, M. K., Kummola, L., Waage, J., Bønnelykke, Klaus, Ruotsalainen, M., Piippo-Savolainen, E., Goksör, E., Nuolivirta, K., Chawes, Bo Lund Krogsgaard, Vissing, N., Bisgaard, H., Jartti, T., Wennergren, G., Junttila, I., Hallman, M., Korppi, M. & Rämet, M., 2018, In: Pediatric Research. 84, p. 451-457

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle

    Stein, M. M., Thompson, E. E., Schoettler, N., Helling, B. A., Magnaye, K. M., Stanhope, C., Igartua, C., Morin, A., Washington, C., Nicolae, D., Bønnelykke, Klaus & Ober, C., 2018, In: Journal of Allergy and Clinical Immunology. 142, 3, p. 749-764.e3

    Research output: Contribution to journal › Review › Research › peer-review

  9. Published

    A functional IFN-λ4-generating DNA polymorphism could protect older asthmatic women from aeroallergen sensitization and associate with clinical features of asthma

    Chinnaswamy, S., Wardzynska, A., Pawelczyk, M., Makowska, J., Skaaby, T., Mercader, J. M., Ahluwalia, T. S., Grarup, Niels, Guindo-Martinez, M., Bisgaard, H., Torrents, D., Linneberg, Allan René, Bønnelykke, Klaus & Kowalski, M. L., 5 Sep 2017, In: Scientific Reports. 7, 1, p. 1-11 11 p., 10500.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways

    Bustamante, M., Standl, M., Bassat, Q., Vilor-Tejedor, N., Medina-Gomez, C., Bonilla, C., Ahluwalia, T. V. S., Bacelis, J., Bradfield, J. P., Tiesler, C. M. T., Rivadeneira, F., Ring, S. M., Vissing, N. H., Fink, N. R., Jugessur, A., Mentch, F. D., Ballester, F., Kriebel, J., Kiefte-de Jong, J. C., Wolsk, H. M. & 19 others, Llop, S., Thiering, E., Beth, S. A., Timpson, N. J., Andersen, J., Schulz, H., Jaddoe, V. W. V., Evans, D. M., Waage, J., Hakonarson, H., Grant, S. F. A., Jacobsson, B., Bønnelykke, Klaus, Bisgaard, H., Davey-Smith, G., Moll, H. A., Heinrich, J., Estivill, X. & Sunyer, J., 2016, In: Human Molecular Genetics. 25, 18, p. 4127-4142

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    A genome-wide association study of total child psychiatric problems scores

    Neumann, A., Nolte, I. M., Pappa, I., Ahluwalia, T. S., Pettersson, E., Rodriguez, A., Whitehouse, A., van Beijsterveldt, C. E. M., Benyamin, B., Hammerschlag, A. R., Helmer, Q., Karhunen, V., Krapohl, E., Lu, Y., van der Most, P. J., Palviainen, T., Pourcain, B. S., Seppälä, I., Suarez, A., Vilor-Tejedor, N. & 41 others, Tiesler, C. M. T., Wang, C., Wills, A., Zhou, A., Alemany, S., Bisgaard, H., Bønnelykke, Klaus, Davies, G. E., Hakulinen, C., Henders, A. K., Hyppönen, E., Stokholm, Jakob, Bartels, M., Hottenga, J., Heinrich, J., Hewitt, J., Keltikangas-Järvinen, L., Korhonen, T., Kaprio, J., Lahti, J., Lahti-Pulkkinen, M., Lehtimäki, T., Middeldorp, C. M., Najman, J. M., Pennell, C., Power, C., Oldehinkel, A. J., Plomin, R., Räikkönen, K., Raitakari, O. T., Rimfeld, K., Sass, L., Snieder, H., Standl, M., Sunyer, J., Williams, G. M., Bakermans-Kranenburg, M. J., Boomsma, D. I., van IJzendoorn, M. H., Hartman, C. A. & Tiemeier, H., 2022, In: PLoS ONE. 17, 8, 23 p., e0273116.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    A novel common variant in DCST2 is associated with length in early life and height in adulthood

    van der Valk, R. J. P., Kreiner-Møller, E., Kooijman, M. N., Guxens, M., Stergiakouli, E., Sääf, A., Bradfield, J. P., Geller, F., Hayes, M. G., Cousminer, D. L., Körner, A., Thiering, E., Curtin, J. A., Myhre, R., Huikari, V., Joro, R., Kerkhof, M., Warrington, N. M., Pitkänen, N., Ntalla, I. & 31 others, Horikoshi, M., Veijola, R., Freathy, R. M., Teo, Y., Barton, S. J., Evans, D. M., Kemp, J. P., St Pourcain, B., Ring, S. M., Davey Smith, G., Bergström, A., Kull, I., Hakonarson, H., Mentch, F. D., Bisgaard, H., Chawes, Bo Lund Krogsgaard, Stokholm, Jakob, Waage, J., Eriksen, P., Sevelsted, A., Melbye, M., van Duijn, C. M., Medina-Gomez, C., Hofman, A., de Jongste, J. C., Taal, H. R., Uitterlinden, A. G., Armstrong, L. L., Pers, Tune H, Bønnelykke, Klaus & Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium, E. G. A. L. E. (. C., 15 Feb 2015, In: Human Molecular Genetics. 24, 4, p. 1155-68 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    A novel method for assessing unchallenged levels of mediators in nasal epithelial lining fluid

    Chawes, Bo Lund Krogsgaard, Edwards, M. J., Shamji, B., Walker, C., Nicholson, G. C., Tan, A. J., Følsgaard, N. V., Bønnelykke, Klaus, Bisgaard, H. & Hansel, T. T., 1 Jun 2010, In: Journal of Allergy and Clinical Immunology. 125, 6, p. 1387-1389.e3

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma

    Smith, D., Helgason, H., Sulem, P., Bjornsdottir, U. S., Lim, A. C., Sveinbjornsson, G., Hasegawa, H., Brown, M., Ketchem, R. R., Gavala, M., Garrett, L., Jonasdottir, A., Jonasdottir, A., Sigurdsson, A., Magnusson, O. T., Eyjolfsson, G. I., Olafsson, I., Onundarson, P. T., Sigurdardottir, O., Gislason, D. & 20 others, Gislason, T., Ludviksson, B. R., Ludviksdottir, D., Boezen, H. M., Heinzmann, A., Krueger, M., Porsbjerg, Celeste Michala, Ahluwalia, T. S., Waage, J., Backer, Vibeke, Deichmann, K. A., Koppelman, G. H., Bønnelykke, Klaus, Bisgaard, H., Masson, G., Thorsteinsdottir, U., Gudbjartsson, D. F., Johnston, J. A., Jonsdottir, I. & Stefansson, K., 2017, In: P L o S Genetics. 13, 3, 24 p., e1006659.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    A saturated map of common genetic variants associated with human height

    Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., Miao, J., Arias, J. D., Graham, S. E., Mukamel, R. E., Spracklen, C. N., Yin, X., Chen, S-H., Ferreira, T., Highland, H. H., Ji, Y. & 37 others, Karaderi, Tugce, Lin, K., Lull, K., Malden, D. E., Lepola, Mette Andersen, Appadurai, V., Bork-Jensen, J., Burgdorf, Kristoffer Sølvsten, Hansen, Thomas Folkmann, Jonsson, Anna Elisabet, Jorgensen, T., Liu, J., Møllehave, Line Tang, Smit, Roelof Adriaan Johan, Zhao, J., Bisgaard, H., Bønnelykke, Klaus, Dantoft, T. M., Grarup, Niels, Hansen, Torben, Jackson, R. D., Karpe, F., Kovacs, P., Lind, L., Linneberg, Allan René, Pedersen, Oluf Borbye, Werge, Thomas, Sun, Y., Loos, Ruth, Winkler, T. W., 23andMe Res Team, 2. R. T., VA Million Vet Program, V. M. V. P., DiscovEHR DiscovEHR MyCode Communi, D. D. M. C., eEMERGE Elect Med Records Genomics, E. E. M. R. G., LifeLines Cohort Study, L. C. S., PRACTICAL consortium, P. C. & Understanding Soc Sci Grp, U. S. S. G., 2022, In: Nature. 610, p. 704–712

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

    Bradfield, J. P., Vogelezang, S., Felix, J. F., Chesi, A., Helgeland, O., Horikoshi, M., Karhunen, V., Lowry, E., Cousminer, D. L., Ahluwalia, T. S., Thiering, E., Boh, E. T-H., Zafarmand, M. H., Vilor-Tejedor, N., Wang, C. A., Joro, R., Chen, Z., Gauderman, W. J., Pitkanen, N., Parra, E. J. & 79 others, Fernandez-Rhodes, L., Alyass, A., Monnereau, C., Curtin, J. A., Have, C. T., McCormack, S. E., Hollensted, M., Frithioff-Bojsoe, C., Valladares-Salgado, A., Peralta-Romero, J., Teo, Y., Standl, M., Leinonen, J. T., Holm, Jens-Christian, Peters, T., Vioque, J., Vrijheid, M., Simpson, A., Custovic, A., Vaudel, M., Canouil, M., Lindi, V., Atalay, M., Kahonen, M., Raitakari, O. T., van Schaik, B. D. C., Berkowitz, R. I., Cole, S. A., Voruganti, V. S., Wang, Y., Highland, H. M., Comuzzie, A. G., Butte, N. F., Justice, A. E., Gahagan, S., Blanco, E., Lehtimaki, T., Lakka, T. A., Hebebrand, J., Bonnefond, A., Grarup, Niels, Froguel, P., Lyytikainen, L., Cruz, M., Kobes, S., Hanson, R. L., Zemel, B. S., Hinney, A., Teo, K. K., Meyre, D., North, K. E., Gilliland, F. D., Bisgaard, H., Bustamante, M., Bønnelykke, Klaus, Pennell, C. E., Rivadeneira, F., Uitterlinden, A. G., Baier, L. J., Vrijkotte, T. G. M., Heinrich, J., Sørensen, Thorkild I.A., Saw, S., Pedersen, Oluf Borbye, Hansen, Torben, Eriksson, J., Widen, E., McCarthy, M. I., Njolstad, P. R., Power, C., Hypponen, E., Sebert, S., Brown, C. D., Jarvelin, M., Timpson, N. J., Johansson, S., Hakonarson, H., Jaddoe, V. W. V. & Grant, S. F. A., 2019, In: Human Molecular Genetics. 28, 19, p. 3327-3338

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Airway immune mediator levels during asthma-like symptoms in young children and their possible role in response to azithromycin

    Carlsson, C. J., Rasmussen, Morten Arendt, Pedersen, S. B., Wang, N., Stokholm, Jakob, Chawes, Bo Lund Krogsgaard, Bønnelykke, Klaus & Bisgaard, H., 2021, In: Allergy: European Journal of Allergy and Clinical Immunology. 76, 6, p. 1754-1764 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Airway obstruction and bronchial reactivity from age 1 month until 13 years in children with asthma: A prospective birth cohort study

    Hallas, H. W., Chawes, Bo Lund Krogsgaard, Rasmussen, Morten Arendt, Arianto, L., Stokholm, Jakob, Bønnelykke, Klaus & Bisgaard, H., 2019, In: PLoS Medicine. 16, 1, 20 p., e1002722.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Allergen Specificity in Specific IgE Cutoff

    Schoos, A. M. M., Hansen, S. M., Skov, F. R., Stokholm, Jakob, Bønnelykke, Klaus, Bisgaard, H. & Chawes, Bo Lund Krogsgaard, 2020, In: JAMA Pediatrics. 174, 10, p. 993-995

    Research output: Contribution to journal › Letter › Research › peer-review

  20. Published

    Antibiotic exposure in infancy and development of BMI and body composition in childhood

    Sejersen, T. S., Vinding, R. K., Stokholm, Jakob, Chawes, Bo Lund Krogsgaard, Bønnelykke, Klaus, Krakauer, M. & Bisgaard, H., 2019, In: EClinicalMedicine. 17, 7 p., 100209.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Association between childhood asthma and attention deficit hyperactivity or autism spectrum disorders: A systematic review with meta-analysis

    Kaas, T. H., Vinding, R. K., Stokholm, Jakob, Bønnelykke, Klaus, Bisgaard, H. & Chawes, Bo Lund Krogsgaard, 2021, In: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 51, 2, p. 228-252 25 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Association between respiratory infections in early life and later asthma is independent of virus type

    Bønnelykke, Klaus, Vissing, N. H., Sevelsted, A., Johnston, S. L. & Bisgaard, H., Jul 2015, In: The Journal of allergy and clinical immunology. 136, 1, p. 81-86.e4 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Association of Asthma Risk Alleles With Acute Respiratory Tract Infections and Wheezing Illnesses in Young Children

    Forsström, V., Toivonen, L., Homil, K., Waris, M., Pedersen, C. T., Bønnelykke, Klaus, Jartti, T. & Peltola, V., 2023, In: The Journal of Infectious Diseases. 228, 8, p. 990-998 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

    Huang, T., Wang, T., Zheng, Y., Ellervik, C., Li, X., Gao, M., Fang, Z., Chai, J-F., Ahluwalia, T. V. S., Wang, Y., Voortman, T., Noordam, R., Frazier-Wood, A., Scholz, M., Sonestedt, E., Akiyama, M., Dorajoo, R., Zhou, A., Kilpeläinen, T. O., Kleber, M. E. & 31 others, Crozier, S. R., Godfrey, K. M., Lemaitre, R., Felix, J. F., Shi, Y., Gupta, P., Khor, C., Lehtimäki, T., Wang, C. A., Tiesler, C. M. T., Thiering, E., Standl, M., Rzehak, P., Marouli, E., He, M., Lecoeur, C., Corella, D., Lai, C., Moreno, L. A., Pitkänen, N., Boreham, C. A., Zhang, T., Hansen, Torben, Sørensen, Thorkild I.A., Tjønneland, Anne, Overvad, K., Bisgaard, H., Pedersen, Oluf Borbye, Bønnelykke, Klaus, Rossing, Peter & BIRTH-GENE (BIG) Study Working Group, B. (. S. W. G., 2019, In: JAMA Network Open. 2, 9, 18 p., e1910915.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring: A 6-Year Follow-up of a Randomized Clinical Trial

    Nørrisgaard, P. E., Haubek, D., Kühnisch, J., Chawes, Bo Lund Krogsgaard, Stokholm, Jakob, Bønnelykke, Klaus & Bisgaard, H., 5 Aug 2019, In: JAMA Pediatrics. 173, 10, p. 924-930 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 1504169