Jiri Lukas
Executive Director, Professor
- 2000
Rapid destruction of human Cdc25A in response to DNA damage
Mailand, Niels, Falck, J., Lukas, Claudia, Syljuåsen, R. G., Welcker, M., Bartek, J. & Lukas, Jiri, 26 May 2000, In: Science (New York, N.Y.). 288, 5470, p. 1425-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway
Santoni Rugiu, Eric, Falck, J., Mailand, Niels, Bartek, J. & Lukas, Jiri, May 2000, In: Molecular and Cellular Biology. 20, 10, p. 3497-509 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
Falck, J., Mailand, Niels, Syljuåsen, R. G., Bartek, J. & Lukas, Jiri, 12 Apr 2001, In: Nature. 410, 6830, p. 842-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology
Lukas, Claudia, Bartkova, J., Latella, L., Falck, J., Mailand, Niels, Schroeder, T., Sehested, M., Lukas, Jiri & Bartek, J., 1 Jul 2001, In: Cancer Research. 61, 13, p. 4990-3 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation
Mailand, Niels, Lukas, Claudia, Kaiser, B. K., Jackson, P. K., Bartek, J. & Lukas, Jiri, Apr 2002, In: Nature Cell Biology. 4, 4, p. 317-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.
Mailand, Niels, Podtelejnikov, A. V., Groth, Anja, Mann, M., Bartek, J. & Lukas, Jiri, 2002, In: EMBO Journal. 21, 21, p. 5911-20 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
E2F activity is essential for survival of Myc-overexpressing human cancer cells
Santoni Rugiu, Eric, Duro, D., Farkas, T., Mathiasen, I. S., Jäättelä, M., Bartek, J. & Lukas, Jiri, 2002, In: Oncogene. 21, 42, p. 6498-6509 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research
Celis, J. E., Gromov, P., Gromova, I., Moreira, J. M. A., Cabezón, T., Ambartsumian, N., Grigorian, M., Lukanidin, E., Thor Straten, P., Guldberg, P., Bartkova, J., Bartek, J., Lukas, J., Lukas, C., Lykkesfeldt, A., Jäättelä, M., Roepstorff, P., Bolund, L., Ørntoft, T. F., Brünner, N. & 5 others, , 2003, In: Molecular and Cellular Proteomics. 2, 6, p. 369-377 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.
Groth, Anja, Lukas, Jiri, Nigg, E., Silljé, H., Wernstedt, C., Bartek, J. & Hansen, K., Apr 2003, In: The EMBO Journal. 22, 7, p. 1676-1687Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
Krämer, A., Mailand, Niels, Lukas, Claudia, Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J. & Lukas, Jiri, Sep 2004, In: Nature Cell Biology. 6, 9, p. 884-91 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
Bartkova, J., Horejsí, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, Claudia, Ørntoft, T., Lukas, Jiri & Bartek, J., 14 Apr 2005, In: Nature. 434, 7035, p. 864-70 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
Liu, S., Bekker-Jensen, Simon Holst, Mailand, Niels, Lukas, Claudia, Bartek, J. & Lukas, Jiri, 2006, In: Molecular and Cellular Biology. 26, 16, p. 6056-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Immunoprecipitation of Proteins under Nondenaturing Conditions
Lukas, Jiri, Bartek, J. & Hansen, K., 1 Dec 2006, Cell Biology, Four-Volume Set. Elsevier Science Inc., Vol. 4. p. 253-258 6 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
Mailand, Niels, Bekker-Jensen, Simon Holst, Bartek, J. & Lukas, Jiri, 2006, In: Molecular Cell. 23, 3, p. 307-18 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks
Bekker-Jensen, Simon Holst, Fugger, K., Danielsen, J. R., Gromova, I., Sehested, M., Celis, J., Bartek, J., Lukas, Jiri & Mailand, Niels, 6 Jul 2007, In: Journal of Biological Chemistry. 282, 27, p. 19638-43 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
Mailand, Niels, Bekker-Jensen, Simon Holst, Faustrup, H., Melander, F., Bartek, J., Lukas, Claudia & Lukas, Jiri, 2007, In: Cell. 131, 5, p. 887-900 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
Melander, F., Bekker-Jensen, Simon Holst, Falck, J., Bartek, J., Mailand, Niels & Lukas, Jiri, 21 Apr 2008, In: Journal of Cell Biology. 181, 2, p. 213-26 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HCLK2 is required for activity of the DNA damage response kinase ATR
Rendtlew Danielsen, J. M., Larsen, D. H., Schou, K. B., Freire, R., Falck, J., Bartek, J. & Lukas, Jiri, 2008, In: Journal of Biological Chemistry. 284, 7, p. 4140-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection
Carson, C. T., Orazio, N. I., Lee, D. V., Suh, J., Bekker-Jensen, Simon Holst, Araujo, F. D., Lakdawala, S. S., Lilley, C. E., Bartek, J., Lukas, Jiri & Weitzman, M. D., 2009, In: EMBO Journal. 28, 6, p. 652-62 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
Doil, C., Mailand, Niels, Bekker-Jensen, Simon Holst, Ménard, Patrice, Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 2009, In: Cell. 136, 3, p. 435-46 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin
Faustrup, H., Bekker-Jensen, Simon Holst, Bartek, J., Lukas, Jiri & Mailand, Niels, 2009, In: Journal of Cell Biology. 184, 1, p. 13-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities
Fugger, K., Mistrik, M., Danielsen, J. R., Dinant, C., Falck, J., Bartek, J., Lukas, Jiri & Mailand, Niels, 2009, In: Journal of Cell Biology. 186, 5, p. 655-63 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA repair: New tales of an old tail
Lukas, Jiri & Bartek, J., 2009, In: Nature. 458, 7238, p. 581-3 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
Marteijn, J. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, Jiri & Vermeulen, W., 2009, In: Journal of Cell Biology. 186, 6, p. 835-47 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis
Mistrik, M., Oplustilova, L., Lukas, Jiri & Bartek, J., 2009, In: Cell Cycle. 8, 16, p. 2592-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 37762642
Most downloads
-
325
downloads
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
175
downloads
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
155
downloads
Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
Research output: Contribution to journal › Journal article › Research › peer-review
Published