Jens Bukh
Professor
Virology
Blegdamsvej 3B, 2200 København N, 07 Bygning 7, Building: 07-13-84
Member of:
- 2018
- Published
Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: A clinical randomized study
Sølund, C., cgl303, cgl303, Mössner, B., Laursen, A. L., Røge, B. T., Kjær, M. S., Gerstoft, Jan, Christensen, P. B., Pedersen, M. S., Schønning, Kristian, Fahnøe, Ulrik, Bukh, Jens & Weis, Nina, 2018, In: European Journal of Gastroenterology and Hepatology. 30, 10, p. 1177-1186 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Mouse models of acute and chronic hepacivirus infection
Billerbeck, E., Wolfisberg, R., Fahnøe, Ulrik, Xiao, J. W., Quirk, C., Luna, J. M., Cullen, J. M., Hartlage, A. S., Chiriboga, L., Ghoshal, K., Lipkin, W. I., Bukh, Jens, Scheel, Troels Kasper Høyer, Kapoor, A. & Rice, C. M., 2017, In: Science. 357, 6347, p. 204-208 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes
Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., Jul 2017, In: Journal of Virology. 91, 14, 18 p., e00130-17.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient hepatitis c virus genotype 1b core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors
Pham, Long, Ramirez Almeida, Santseharay, Carlsen, T. H. R., Li, Y., Gottwein, Judith Margarete & Bukh, Jens, 2017, In: Antimicrobial Agents and Chemotherapy. 61, 6, 19 p., e00037-17.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae
Smith, D. B., Meyers, G., Bukh, Jens, Gould, E. A., Monath, T., Muerhoff, A. S., Pletnev, A., Rico-Hesse, R., Stapleton, J. T., Simmonds, P. & Becher, P., 2017, In: Journal of General Virology. 98, 8, p. 2106-2112 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A
Velazquez-Moctezuma, R., Law, M., Bukh, Jens & Prentø, Jannick, Feb 2017, In: PLOS Pathogens. 13, 2, 29 p., 1006214.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control
Bukh, Jens, Oct 2016, In: Journal of Hepatology. 65, 1 Suppl., p. S2-S21Research output: Contribution to journal › Review › Research › peer-review
- Published
Functional analysis of microRNA-122 binding sequences of hepatitis C virus and identification of variants with high resistance against specific antagomir
Li, Y., Pham, Long, Uzcategui, N. & Bukh, Jens, Jun 2016, In: Journal of General Virology. 97, p. 1381-1394Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neutralizing antibodies in patients with chronic hepatitis C and correlation to liver cirrhosis and estimated duration of infection
Pedersen, J., Lundbo, L. F., Krarup, H., Bukh, Jens & Weis, Nina, Oct 2016, In: Journal of Medical Virology. 88, 10, p. 1791-1803 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice
Prentø, Jannick, Verhoye, L., Moctezuma, R. V., Buysschaert, C., Farhoudi, A., Wang, R., Alter, H., Meuleman, P. & Bukh, Jens, Dec 2016, In: Gut. 65, 12, p. 1988-1997 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hypervariable Region 1 Shielding of Hepatitis C Virus Is a Main Contributor to Genotypic Differences in Neutralization Sensitivity
Prentø, Jannick, Velazquez-Moctezuma, R., Foung, S. K. H., Law, M. & Bukh, Jens, Dec 2016, In: Hepatology. 64, 6, p. 1881-1892 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir
Ramirez Almeida, Santseharay, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Nov 2016, In: Gastroenterology. 151, 5, p. 973-985.e2Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.
Serre, S., Jensen, S., Ghanem, L., Humes, D., Ramirez, S., Li, Y., Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, Jun 2016, In: Antimicrobial Agents and Chemotherapy. 60, 6, p. 3563-3578 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family
Smith, D. B., Becher, P., Bukh, Jens, Gould, E. A., Meyers, G., Monath, T., Muerhoff, A. S., Pletnev, A., Rico-Hesse, R., Stapleton, J. T. & Simmonds, P., Nov 2016, In: Journal of General Virology. 97, p. 2894-2907 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge
Bukh, Jens, Engle, R. E., Faulk, K., Wang, R. Y., Farci, P., Alter, H. J. & Purcell, R. H., Sep 2015, In: Journal of Virology. 89, 17, p. 9128-9132 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell culture system of a hepatitis C genotype 3a and 2a chimera: Patent #: 8,945,584
Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 3 Feb 2015, IPC No. A61K 39/29 (20060101); C12N 15/06 (20060101); C12Q 1/02 (20060101); C07H 21/00 (20060101); C12N 7/02 (20060101); A61K 39/12 (20060101), Patent No. WO2008/125117, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050083Research output: Patent
- Published
Infectious hepatitis C viruses of genotype 3A and 4A and uses thereof: Patent #: 8,946,398
Gottwein, Judith Margarete, Scheel, T. K. H., Purcell, R. E. & Bukh, Jens, 3 Feb 2015, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2011/038737, 26 Jul 2012, Priority date 16 Sep 2010, Priority No. PCT/DK2010/050236Research output: Patent
- Published
Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance
Jensen, S. B., Serre, S. B. N., Humes, D. G., Ramirez Almeida, Santseharay, Li, Y., Bukh, Jens & Gottwein, Judith Margarete, Dec 2015, In: Antimicrobial Agents and Chemotherapy. 59, 12, p. 7426-7436 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77
Li, Y., Ramirez Almeida, Santseharay, Mikkelsen, L. & Bukh, Jens, Jan 2015, In: Journal of Virology. 89, 1, p. 811-23 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant
Mathiesen, C. K., Prentø, Jannick, Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, Judith Margarete & Bukh, Jens, Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a
Carlsen, T. H. R., Pedersen, J., Prentø, Jannick, Giang, E., Keck, Z., Mikkelsen, L. S., Law, M., Foung, S. K. H. & Bukh, Jens, Nov 2014, In: Hepatology. 60, 5, p. 1551-62 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic variation in toll-like receptors and retinoic acid-inducible gene I and outcome of hepatitis C virus infection: a candidate gene association study
Clausen, L. N., Ladelund, S., Weis, Nina, Bukh, Jens & Benfield, Thomas, Aug 2014, In: Journal of Viral Hepatitis. 21, 8, p. 578-84 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transfusion-associated hepatitis before the screening of blood for hepatitis risk factors
Engle, R. E., Bukh, Jens, Alter, H. J., Emerson, S. U., Trenbeath, J. L., Nguyen, H. T., Brockington, A., Mitra, T. & Purcell, R. H., Nov 2014, In: Transfusion. 54, 11, p. 2833-41 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus
Galli, A. & Bukh, Jens, Jun 2014, In: Trends in Microbiology. 22, 6, p. 354-64 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Efficient cell culture system for hepatitis C virus genotype 2B: Patent #: 8,663,653
Gottwein, Judith Margarete, Knudsen, M. L., Scheel, T. K. H. & Bukh, Jens, 31 Mar 2014, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12N 1/20 (20060101); C12N 5/071 (20100101); C12N 15/00 (20060101); C12Q 1/70 (20060101), Patent No. WO2010/017818, 18 Feb 2010, Priority date 24 Jul 2009, Priority No. PCT/DK2009/050189Research output: Patent
ID: 12437
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Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies
Research output: Contribution to journal › Review › Research › peer-review
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382
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Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies
Research output: Contribution to journal › Journal article › Research › peer-review
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344
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Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry
Research output: Contribution to journal › Review › Research › peer-review
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