Inge Marie Svane
Clinical Professor
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Restoring tumor immunogenicity with dendritic cell reprogramming
Zimmermannova, O., Ferreira, A. G., Ascic, E., Santiago, M. V., Kurochkin, I., Hansen, M., Met, Ö., Caiado, I., Shapiro, I. E., Michaux, J., Humbert, M., Soto-Cabrera, D., Benonisson, H., Silvério-Alves, R., Gomez-Jimenez, D., Bernardo, C., Bauden, M., Andersson, R., Höglund, M., Miharada, K. & 9 others, , 2023, In: Science immunology. 8, 85, 20 p., eadd4817.Research output: Contribution to journal › Journal article › Research › peer-review
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Fibrotic activity quantified in serum by measurements of type III collagen pro-peptides can be used for prognosis across different solid tumor types
Willumsen, N., Jensen, C., Green, G., Nissen, N. I., Neely, J., Nelson, D. M., Pedersen, R. S., Frederiksen, P., Chen, I. M., Boisen, M. K., Johansen, A. Z., Madsen, D. H., Svane, I. M., Lipton, A., Leitzel, K., Ali, S. M., Erler, J. T., Hurkmans, D. P., Mathijssen, R. H. J., Aerts, J. & 5 others, , 2022, In: Cellular and Molecular Life Sciences. 79, 4, 11 p., 204.Research output: Contribution to journal › Review › Research › peer-review
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Assessment of extracellular matrix and tissue derived metabolites in a liquid biopsy for identifying endotypes of metastatic melanoma patients with differential response to immune checkpoint inhibitor treatment.
Willumsen, N., Bager, C. L., Jensen, C., Karsdal, M. A., Madsen, Daniel Hargbøl, Hansen, M., Schmidt, H. & Svane, Inge Marie, 2019, In: Journal of Clinical Oncology. 37, 15_suppl, e14050.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Changes in the Tumor Immune Microenvironment during Disease Progression in Patients with Ovarian Cancer
Westergaard, M. C. W., Milne, K., Pedersen, M., Hasselager, T., Olsen, L. R., Anglesio, M. S., Borch, T. H., Kennedy, M., Briggs, G., Ledoux, S., Kreuzinger, C., Decken, I. V. D., Donia, M., Castillo-Tong, D. C., Nelson, B. H. & Svane, Inge Marie, 2020, In: Cancers. 12, 12, 19 p., 3828.Research output: Contribution to journal › Journal article › Research › peer-review
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Tumour-reactive T cell subsets in the microenvironment of ovarian cancer
Westergaard, M. C. W., Andersen, R., Chong, C., Kjeldsen, J. W., Pedersen, M., Friese, C., Hasselager, T., Lajer, H., Coukos, G., Bassani-Sternberg, M., dqp123, dqp123 & Svane, Inge Marie, 2019, In: British Journal of Cancer. 120, p. 424-434Research output: Contribution to journal › Journal article › Research › peer-review
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RhoC a new target for therapeutic vaccination against metastatic cancer
Wenandy, L., Sorensen, R. B., Straten, P. T., Andersen, M. H. & Svane, Inge Marie, 2008, In: Cancer Immunology, Immunotherapy. 57, 12, p. 1871-1878 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunogenicity of the hTERT540-548 peptide in cancer
Wenandy, L., Sorensen, R. B., Sengelov, L., Straten, P. T., Andersen, M. H. & Svane, Inge Marie, 2008, In: Clinical Cancer Research. 14, 1, p. 4-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The 1170 A-P single-nucleotide polymorphism (SNP) in the Her-2/neu protein (HER2) as a minor histocompatibility antigen (mHag)
Wenandy, L., Kollgaard, T., Letsch, A., Andersen, R. S., Stather, D., Seremet, T., Svane, Inge Marie, Vindeløv, L., Andersen, M. H. & thor Straten, P., 2009, In: Leukemia. 23, 10, p. 1926-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Weis-Banke, S. E., Lisle, T. L., Perez Penco, Maria, Schina, A., Hübbe, M. L., Siersbæk, M., Holmström, M. O., Jørgensen, M. A., Svane, Inge Marie, Met, Özcan, Ødum, Niels, Madsen, Daniel Hargbøl, dqp123, dqp123, Grøntved, L. & Andersen, Mads Hald, 2022, In: Journal for ImmunoTherapy of Cancer. 10, 10, e005326.Research output: Contribution to journal › Journal article › Research › peer-review
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The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines
Weis-Banke, S. E., Hübbe, M. L., Holmström, M. O., Jørgensen, M. A., Bendtsen, S. K., Martinenaite, E., Carretta, M., Svane, Inge Marie, Ødum, Niels, Pedersen, A. W., Met, Özcan, Madsen, D. H. & Andersen, Mads Hald, 2020, In: OncoImmunology. 9, 1, 16 p., 1771142.Research output: Contribution to journal › Journal article › Research › peer-review
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Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
Weber, J. S., D'Angelo, S. P., Minor, D., Hodi, F. S., Gutzmer, R., Neyns, B., Hoeller, C., Khushalani, N. I., Miller, W. H., Lao, C. D., Linette, G. P., Thomas, L., Lorigan, P., Grossmann, K. F., Hassel, J. C., Maio, M., Sznol, M., Ascierto, P. A., Mohr, P., Chmielowski, B. & 8 others, , Apr 2015, In: Lancet Oncology. 16, 4, p. 375-84 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunoprofiles of colorectal cancer from Lynch syndrome
Walkowska, J., Kallemose, T., Jönsson, G., Jönsson, M., Andersen, Ove, Andersen, Mads Hald, Svane, Inge Marie, Langkilde, A., Nilbert, Mef Christina & Therkildsen, C., 2019, In: OncoImmunology. 8, 1, 9 p., e1515612.Research output: Contribution to journal › Journal article › Research › peer-review
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T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients
Viborg, N., Ramskov, S., Andersen, R. S., Sturm, T., Fugmann, T., Bentzen, A. K., Rafa, V. M., Straten, P. T., Svane, Inge Marie, Met, Özcan & Hadrup, S. R., 2019, In: OncoImmunology. 8, 12, 11 p., 1663107.Research output: Contribution to journal › Journal article › Research › peer-review
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Combination therapy with immune check point inhibitors and acute kidney injury
Valentin, A., Møller, A. K. H., Palshof, J. A., Broberg, B., Gravesen, E., Svane, Inge Marie & Hansen, Ditte, 2023, In: Acta Oncologica. 62, 2, p. 121-125 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy
Tvingsholm, S. A., Frej, M. S., Rafa, V. M., Hansen, U. K., Ormhøj, M., Tyron, A., Jensen, A. W. P., Kadivar, M., Bentzen, A. K., Munk, K. K., Aasbjerg, G. N., Ternander, J. S. H., Heeke, C., Tamhane, T., Schmess, C., Funt, S. A., Kjeldsen, J. W., Kverneland, A. H., Met, Ö., Draghi, A. & 4 others, , 2023, In: Journal for ImmunoTherapy of Cancer. 11, 8, 16 p., e006847.Research output: Contribution to journal › Journal article › Research › peer-review
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Antibody Stabilization of Peptide–MHC Multimers Reveals Functional T Cells Bearing Extremely Low-Affinity TCRs
Tungatt, K., Bianchi, V., Crowther, M. D., Powell, W. E., Schauenburg, A. J., Trimby, A., Donia, M., Miles, J. J., Holland, C. J., Cole, D. K., Godkin, A. J., Peakman, M., Straten, P. T., Svane, Inge Marie, Sewell, A. K. & Dolton, G., Jan 2015, In: Journal of immunology (Baltimore, Md. : 1950). 194, 1, p. 463-474 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased immunopotency of monocyte derived dendritic cells from patients with optic neuritis is inhibited in vitro by simvastatin
Tsakiri, A., Tsiantoulas, D., Fredriksen, Jette Lautrup & Svane, Inge Marie, 1 Feb 2010, In: Experimental Neurology. 221, 2, p. 320-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effector and regulatory T cells in patients with acute optic neuritis
Tsakiri, A., Kjærsgaard, E., Grigoriadis, N., Svane, Inge Marie & Frederiksen, J. L., 2012, In: Neuroimmunomodulation. 19, 2, p. 111-20 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuroprotective and anti-inflammatory mechanisms are activated early in optic neuritis
Tsakiri, A., Ravanidis, S., Lagoudaki, R., Poulatsidou, K., Svane, Inge Marie, Fredriksen, Jette Lautrup & Grigoriadis, N., May 2015, In: Acta Neurologica Scandinavica. 131, 5, p. 305-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Addition of interferon-alpha to a standard maturation cocktail induces CD38 up-regulation and increases dendritic cell function
Trepiakas, R., Pedersen, Anders Elm, Met, Özcan & Svane, Inge Marie, 2009, In: Vaccine. 27, 16, p. 2213-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a phase I/II trial
Trepiakas, R., Berntsen, A., Hadrup, S. R., Bjørn, J., Geertsen, P. F., Straten, P. T., Andersen, Mads Hald, Pedersen, Anders Elm, Soleimani, A., Lorentzen, T., Johansen, Julia Sidenius & Svane, Inge Marie, 1 Oct 2010, In: Cytotherapy. 12, 6, p. 721-34 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2
Sørensen, R. B., Køllgaard, T., Andersen, R. S., van den Berg, J. H., Svane, Inge Marie, Straten, P. T. & Andersen, Mads Hald, 15 Mar 2011, In: Cancer Research. 71, 6, p. 2038-44 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The immune system strikes back: cellular immune responses against indoleamine 2,3-dioxygenase
Sørensen, R. B., Berge-Hansen, L., Junker, N., Hansen, C. A., Hadrup, S. R., Schumacher, T. N. M., Svane, Inge Marie, Becker, J. C., thor Straten, P. & Andersen, Mads Hald, 2009, In: PLoS ONE. 4, 9, p. e6910Research output: Contribution to journal › Journal article › Research › peer-review
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CD8 T-cell responses against cyclin B1 in breast cancer patients with tumors overexpressing p53
Sørensen, R. B., Andersen, R. S., Svane, Inge Marie, Engell-Noerregaard, L., Hadrup, S. R., Balslev, E., Andersen, Mads Hald & thor Straten, P., 2009, In: Clinical Cancer Research. 15, 5, p. 1543-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators
Sørensen, R. B., Hadrup, S. R., Svane, Inge Marie, Hjortsø, M. C., Thor Straten, P., Andersen, Mads Hald, Hjortsø, M. C. & Andersen, Mads Hald, 17 Feb 2011, In: Blood. 117, 7, p. 2200-10 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The immunodominant HLA-A2-restricted MART-1 epitope is not presented on the surface of many melanoma cell lines
Sørensen, R. B., Junker, N., Kirkin, A., Voigt, H., Svane, Inge Marie, Becker, J. C., thor Straten, P. & Andersen, Mads Hald, 2009, In: Cancer Immunology, Immunotherapy. 58, 5, p. 665-75 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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B-cell frequencies and immunoregulatory phenotypes in myeloproliferative neoplasms: influence of ruxolitinib, interferon-α2, or combination treatment
Sørensen, A. L., Bjørn, M. E., Riley, C. H., Holmstrøm, M., Andersen, Mads Hald, Svane, Inge Marie, Mikkelsen, S. U., Skov, V., Kjær, L., Hasselbalch, H. C. & Nielsen, C. H., 2019, In: European Journal of Haematology. 103, 4, p. 351-361 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Achievements and challenges of adoptive T cell therapy with tumor-infiltrating or blood-derived lymphocytes for metastatic melanoma: what is needed to achieve standard of care?
Svane, Inge Marie & Verdegaal, E. M., 2014, In: Cancer immunology, immunotherapy : CII. 63, 10, p. 1081-1091 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comment on "Adoptive T-cell therapy for malignant melanoma patients with TILs obtained by ultrasound-guided needle biopsy" by Gustav J. Ullenhag et al
Svane, Inge Marie, 2012, In: Cancer Immunology, Immunotherapy. 61, 5, p. 747; author reply 749Research output: Contribution to journal › Journal article › Research › peer-review
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Clinical application of dendritic cells in cancer vaccination therapy
Svane, Inge Marie, Soot, M. L., Buus, Søren & Johnsen, H. E., 2003, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 111, 7-8, p. 818-34 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of Spontaneous Immune Responses against Long Peptides Derived from Bcl-X(L) in Cancer Patients Using Elispot
Svane, Inge Marie, Straten, P. T., Andersen, M. H., Larsen, S. K. & Hansen, M., 2012, In: Cells. 1, 2, p. 51-60 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neurologiske bivirkninger af cancerimmunterapi med checkpointinhibitorer
Stenör, C., Ellebæk, E., El Mahdaoui, S. & Svane, Inge Marie, 11 Jan 2021, In: Ugeskrift for Laeger. 183, 2, 9 p., V05200406.Research output: Contribution to journal › Journal article › Research › peer-review
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PD-L1 expression and survival among melanoma patients treated with standard immunotherapy or chemotherapy
Steiniche, T., Vestergaard Danielsen, A., Wang, Z., Feng, Y., Switten Nielsen, P., Bastholt, L., Schmidt, H., Svane, Inge Marie, Dolled-Filhart, M., Emancipator, K., Weiner, R., Busch-Sørensen, M. & Zhou, W., 2017, In: Journal of the European Academy of Dermatology and Venereology. 31, 7, p. e319-e321Research output: Contribution to journal › Comment/debate › Research
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Randomised phase II trial of stereotactic body radiotherapy in combination with checkpoint inhibitors in metastatic castration-resistant prostate cancer (CheckPRO): a study protocol
Spindler, N. J., Persson, Gitte F., Theile, S., Nielsen, D. L., Høgdall, Estrid Vilma Solyom, Al-Farra, G., Hendel, Helle Westergren, Lorentzen, T., Svane, Inge Marie, Lindberg, H. & Eefsen, R. L., 2023, In: BMJ Open. 13, 1, 8 p., e063500.Research output: Contribution to journal › Journal article › Research › peer-review
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Immune responses in patients with metastatic renal cell carcinoma treated with dendritic cells pulsed with tumor lysate
Soleimani, A., Berntsen, A., Svane, Inge Marie & Pedersen, Anders Elm, 2009, In: Scandinavian Journal of Immunology. 70, 5, p. 481-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Improved progression-free long-term survival of a nation-wide patient population with metastatic melanoma
Soerensen, A. V., Ellebaek, E., Bastholt, L., Schmidt, H., dqp123, dqp123 & Svane, Inge Marie, 2020, In: Cancers. 12, 9, p. 1-11 11 p., 2591.Research output: Contribution to journal › Journal article › Research › peer-review
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Immunterapi til patienter med malignt melanom og hjernemetastaser
Simonsen, L. T., Schmidt, A. M. S., Øllegaard, T. H., Svane, Inge Marie, Bastholt, L., Luczak, A. A. & Schmidt, H., 2019, In: Ugeskrift for Laeger. 181, 24, 5 p., V01190057.Research output: Contribution to journal › Journal article › Research › peer-review
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Cutaneous adverse reactions to anti–PD-1 treatment—A systematic review
Simonsen, Anne Birgitte Nørremark, Kaae, Jeanette, Ellebaek, E., Svane, Inge Marie & Zachariae, Claus, 1 Nov 2020, In: Journal of the American Academy of Dermatology. 83, 5, p. 1415-1424 10 p.Research output: Contribution to journal › Review › Research › peer-review
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Large-scale mRNA transfection of dendritic cells by electroporation in continuous flow systems
Selmeczi, D., Hansen, T. S., Met, Özcan, Svane, Inge Marie & Larsen, N. B., 2016, Methods in Molecular Biology. Humana Press, Vol. 1428. p. 151-161 11 p. (Methods in Molecular Biology, Vol. 1428).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Efficient large volume electroporation of dendritic cells through micrometer scale manipulation of flow in a disposable polymer chip
Selmeczi, D., Hansen, T., Met, Ö., Svane, Inge Marie & Larsen, N., 2011, In: Biomedical Microdevices. 13, 2, p. 383-92 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficient large volume electroporation of dendritic cells through micrometer scale manipulation of flow in a disposable polymer chip
Selmeczi, D., Hansen, T. S., Met, Özcan, Svane, Inge Marie & Larsen, N. B., Apr 2011, In: Biomedical Microdevices. 13, 2, p. 383-92 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Safety and clinical effect of subcutaneous human interleukin-21 in patients with metastatic melanoma or renal cell carcinoma: a phase I trial
Schmidt, H., Brown, J., Mouritzen, U., Selby, P., Fode, K., Svane, Inge Marie, Cook, G. P., Mollerup, D. H. & Geertsen, P. F., 1 Nov 2010, In: Clinical Cancer Research. 16, 21, p. 5312-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intratumoral T-cell and B-cell receptor architecture associates with distinct immune tumor microenvironment features and clinical outcomes of anti-PD-1/L1 immunotherapy
Schina, A., Sztupinszki, Z., Svane, Inge Marie, Szallasi, Z., Jönsson, G. & Donia, M., 2023, In: Journal for ImmunoTherapy of Cancer. 11, 8, 12 p., 006941.Research output: Contribution to journal › Journal article › Research › peer-review
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Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells
Saini, S. K., Tamhane, T., Anjanappa, R., Saikia, A., Ramskov, S., dqp123, dqp123, Svane, Inge Marie, Jakobsen, S. N., Garcia-Alai, M., Zacharias, M., Meijers, R., Springer, S. & Hadrup, S. R., 2019, In: Science immunology. 4, 37, eaau9039.Research output: Contribution to journal › Journal article › Research › peer-review
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Manufacture of adoptive cell therapies at academic cancer centers: scientific, safety and regulatory challenges
Saini, K. S., Svane, Inge Marie, Juan, M., Barlesi, F. & André, F., 2022, In: Annals of Oncology. 33, 1, p. 6-12 7 p.Research output: Contribution to journal › Editorial › Research › peer-review
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Characterization of risk factors and efficacy of medical management of immune-related hepatotoxicity in real-world patients with metastatic melanoma treated with immune checkpoint inhibitors
Romanski, N. A., Holmstroem, R. B., Ellebaek, E. & Svane, Inge Marie, 2020, In: European Journal of Cancer. 130, p. 211-218Research output: Contribution to journal › Journal article › Research › peer-review
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Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma.
Rohaan, M. W., Borch, T. H., Van Den Berg, J. H., Met, Ö., Kessels, R., Geukes Foppen, M. H., Stoltenborg Granhøj, J., Nuijen, B., Nijenhuis, C., Jedema, I., Van Zon, M., Scheij, S., Beijnen, J. H., Hansen, M., Voermans, C., Noringriis, I. M., Monberg, T. J., Holmstroem, R. B., Wever, L. D. V., Van Dijk, M. & 37 others, , 2022, In: New England Journal of Medicine. 387, 23, p. 2113-2125 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations
Rius, C., Attaf, M., Tungatt, K., Bianchi, V., Legut, M., Bovay, A., dqp123, dqp123, Thor Straten, P., Peakman, M., Svane, Inge Marie, Ott, S., Connor, T., Szomolay, B., Dolton, G. & Sewell, A. K., 2018, In: The Journal of Immunology. 200, 7, p. 2263-2279Research output: Contribution to journal › Journal article › Research › peer-review
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Increase in circulating CD4⁺CD25⁺Foxp3⁺ T cells in patients with Philadelphia-negative chronic myeloproliferative neoplasms during treatment with IFN-α
Riley, C. H., Jensen, M. K., Brimnes, M. K., Hasselbalch, H. C., Bjerrum, O. W., Straten, P. T. & Svane, Inge Marie, 2011, In: Blood. 118, 8, p. 2170-3 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Expansion of circulating CD56bright natural killer cells in patients with JAK2-positive chronic myeloproliferative neoplasms during treatment with interferon-α
Riley, C. H., Hansen, M., Brimnes, M. K., Hasselbalch, H. C., Bjerrum, O. W., Straten, P. T., Svane, Inge Marie & Jensen, M. K., Mar 2015, In: European Journal of Haematology. 94, 3, p. 227–234 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4054758
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Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma
Research output: Contribution to journal › Journal article › Research › peer-review
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257
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T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients
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189
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Survival of metastatic melanoma patients after dendritic cell vaccination correlates with expression of leukocyte phosphatidylethanolamine-binding protein 1/Raf kinase inhibitory protein
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