Helena Safavi

Helena Safavi

Associate Professor, Guest Researcher

Member of:

    ORCID: 0000-0002-1984-2721

    Publication year:
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    1 - 42 out of 42Page size: 50
    1. 2023
    2. Published

      A toxin-based approach to neuropeptide and peptide hormone discovery

      Koch, Thomas Lund, Torres, Joshua, Baskin, R. P., Salcedo, P. F., Chase, K., Olivera, B. M. & Safavi, Helena, 2023, In: Frontiers in Molecular Neuroscience. 16, 14 p., 1176662.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2022
    4. Published

      Integrating Venom Peptide Libraries Into a Phylogenetic and Broader Biological Framework

      Chase, K., Watkins, M., Safavi, Helena & Olivera, B. M., 2022, In: Frontiers in Molecular Biosciences. 9, 16 p., 784419.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Symmetric and asymmetric receptor conformation continuum induced by a new insulin

      Xiong, X., Blakely, A., Kim, J. H., Menting, J. G., Schäfer, I. B., Schubert, H. L., Agrawal, R., Gutmann, T., Delaine, C., Zhang, Y. W., Artik, G. O., Merriman, A., Eckert, D., Lawrence, M. C., Coskun, Ü., Fisher, S. J., Forbes, B. E., Safavi, Helena, Hill, C. P. & Chou, D. H. C., 2022, In: Nature Chemical Biology. 18, 5, p. 511-519

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Unconventional insulins from predators and pathogens

      Laugesen, S. H., Chou, D. H. C. & Safavi, Helena, 2022, In: Nature Chemical Biology. 18, 7, p. 688-697

      Research output: Contribution to journal › Review › Research › peer-review

    7. 2021
    8. Published

      DisCoTune: versatile auxiliary plasmids for the production of disulphide-containing proteins and peptides in the E. coli T7 system

      Bertelsen, A. B., Hackney, Celeste Menuet, Bayer, C. N., Kjelgaard, L. D., Rennig, M., Christensen, B., Sørensen, E. S., Safavi, Helena, Wulff, T., Ellgaard, Lars & Nørholm, M. H. H., 2021, In: Microbial Biotechnology. 14, 6, p. 2566-2580 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 2020
    10. Published

      A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

      Xiong, X., Menting, J. G., Disotuar, M. M., Smith, N. A., Delaine, C. A., Ghabash, G., Agrawal, R., Wang, X., He, X., Fisher, S. J., MacRaild, C. A., Norton, R. S., Gajewiak, J., Forbes, B. E., Smith, B. J., Safavi, Helena, Olivera, B., Lawrence, M. C. & Chou, D. H. C., 2020, In: Nature Structural and Molecular Biology. 27, p. 615-624

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research

      Bjørn-Yoshimoto, Walden, Ramiro, Iris Bea L. , Yandell, M., McIntosh, J. M., Olivera, B. M., Ellgaard, Lars & Safavi, Helena, 2020, In: Biomedicines. 8, 8, 22 p., 235.

      Research output: Contribution to journal › Review › Research › peer-review

    12. Published

      Transcriptomic Profiling Reveals Extraordinary Diversity of Venom Peptides in Unexplored Predatory Gastropods of the Genus Clavus

      Lu, A., Watkins, M., Li, Q., Robinson, S. D., Concepcion, G. P., Yandell, M., Weng, Z., Olivera, B. M., Safavi, Helena & Fedosov, A. E., 2020, In: Genome Biology and Evolution. 12, 5, p. 684-700 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. 2019

    14. Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

      Ahorukomeye, P., Disotuar, M. M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S. D., Flórez Salcedo, P., Smith, N. A., Smith, B. J., Schlegel, A., Forbes, B. E., Olivera, B., Hung-Chieh Chou, D. & Safavi, Helena, 2019, In: eLife. 8, 28 p., e41574.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways

      Safavi, Helena, Brogan, S. E. & Olivera, B. M., 2019, In: Journal of Proteomics. 190, p. 12-20 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

      Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi, Helena, Teilum, Kaare & Ellgaard, Lars, 2019, In: The Journal of Biological Chemistry. 294, 22, p. 8745-8759

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. 2018

    18. Conopeptides promote itch through human itch receptor hMgprX1

      Espino, S. S., Robinson, S. D., Safavi, Helena, Gajewiak, J., Yang, W., Olivera, B. M. & Liu, Q., 2018, In: Toxicon. 154, p. 28-34 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Discovery of Novel Conotoxin Candidates Using Machine Learning

      Li, Q., Watkins, M., Robinson, S. D., Safavi, Helena & Yandell, M., 2018, In: Toxins. 10, 12, 503.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins

      O'Brien, H., Kanemura, S., Okumura, M., Baskin, R. P., Bandyopadhyay, P. K., Olivera, B. M., Ellgaard, Lars, Inaba, K. & Safavi, Helena, 2018, In: International Journal of Molecular Sciences . 19, 11, 15 p., 3418.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Evolutionary Adaptations to Cysteine-rich Peptide Folding

      Safavi, Helena, Foged, M. M. & Ellgaard, Lars, 2018, Oxidative Folding of Proteins: Basic Principles, Cellular Regulation and Engineering . Feige, M. J. (ed.). Royal Society of Chemistry, p. 99-128 30 p. (Chemical Biology, Vol. 9).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    22. 2017
    23. Published

      Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study

      Olivera, B. M., Raghuraman, S., Schmidt, E. W. & Safavi, Helena, Oct 2017, In: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 203, 9, p. 717-735 19 p.

      Research output: Contribution to journal › Review › Research › peer-review

    24. Published

      Hormone-like peptides in the venoms of marine cone snails

      Robinson, S. D., Li, Q., Bandyopadhyay, P. K., Gajewiak, J., Yandell, M., Papenfuss, A. T., Purcell, A. W., Norton, R. S. & Safavi, Helena, 1 Apr 2017, In: General and Comparative Endocrinology. 244, p. 11-18 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus

      Li, Q., Barghi, N., Lu, A., Fedosov, A. E., Bandyopadhyay, P. K., Lluisma, A. O., Concepcion, G. P., Yandell, M., Olivera, B. M. & Safavi, Helena, 2017, In: Genome Biology and Evolution. 9, 9, p. 2211-2225 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Isolation and characterization of Conohyal-P1, a hyaluronidase from the injected venom of Conus purpurascens

      Möller, C., Clark, E., Safavi, Helena, DeCaprio, A. & Marí, F., 2017, In: Journal of Proteomics. 164, p. 73-84 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea

      Robinson, S. D., Li, Q., Lu, A., Bandyopadhyay, P. K., Yandell, M., Olivera, B. M. & Safavi, Helena, 2017, In: Marine Drugs. 15, 5, 145.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Venom peptides as pharmacological tools and therapeutics for diabetes

      Robinson, S. D. & Safavi, Helena, 2017, In: Neuropharmacology. 127, p. 79-86 8 p.

      Research output: Contribution to journal › Review › Research › peer-review

    29. 2016

    30. A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold

      Robinson, S. D., Chhabra, S., Belgi, A., Chittoor, B., Safavi, Helena, Robinson, A. J., Papenfuss, A. T., Purcell, A. W. & Norton, R. S., 2016, In: Structure. 24, 2, p. 293-299 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

      Menting, J. G., Gajewiak, J., MacRaild, C. A., Chou, D. H., Disotuar, M. M., Smith, N. A., Miller, C., Erchegyi, J., Rivier, J. E., Olivera, B. M., Forbes, B. E., Smith, B. J., Norton, R. S., Safavi, Helena & Lawrence, M. C., 2016, In: Nature Structural and Molecular Biology. 23, 10, p. 916-920 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. A prominent role of PDIA6 in processing of misfolded proinsulin

      Gorasia, D. G., Dudek, N. L., Safavi, Helena, Perez, R. A., Schittenhelm, R. B., Saunders, P. M., Wee, S., Mangum, J. E., Hubbard, M. J. & Purcell, A. W., 2016, In: B B A - Reviews on Cancer. 1864, 6, p. 715-723 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Insulin as a weapon

      Robinson, S. D. & Safavi, Helena, 2016, In: Toxicon. 123, p. 56-61 6 p.

      Research output: Contribution to journal › Review › Research › peer-review

    34. Published

      Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

      Safavi, Helena, Li, Q., Jackson, R. L., Song, A. S., Boomsma, Wouter, Bandyopadhyay, P. K., Gruber, C. W., Purcell, A. W., Yandell, M., Olivera, B. M. & Ellgaard, Lars, 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. 3227-3232 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Venom insulins of cone snails diversify rapidly and track prey taxa

      Safavi, Helena, Lu, A., Li, Q., Fedosov, A. E., Biggs, J., Corneli, P. S., Seger, J., Yandell, M. & Olivera, B. M., 2016, In: Molecular Biology and Evolution. 33, 11, p. 2924-2934 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. 2015

    37. Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom

      Robinson, S. D., Safavi, Helena, Raghuraman, S., Imperial, J. S., Papenfuss, A. T., Teichert, R. W., Purcell, A. W., Olivera, B. M. & Norton, R. S., 2015, In: Journal of Proteomics. 114, p. 38-47 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus

      Aman, J. W., Imperial, J. S., Ueberheide, B., Zhang, M., Aguilar, M., Taylor, D., Watkins, M., Yoshikami, D., Showers-Corneli, P., Safavi, Helena, Biggs, J., Teichert, R. W. & Olivera, B. M., 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 16, p. 5087-5092 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Pancreatic beta cells are highly susceptible to oxidative and ER stresses during the development of diabetes

      Gorasia, D. G., Dudek, N. L., Veith, P. D., Shankar, R., Safavi, Helena, Williamson, N. A., Reynolds, E. C., Hubbard, M. J. & Purcell, A. W., 2015, In: Journal of Proteome Research. 14, 2, p. 688-99 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Specialized insulin is used for chemical warfare by fish-hunting cone snails

      Safavi, Helena, Gajewiak, J., Karanth, S., Robinson, S. D., Ueberheide, B., Douglass, A. D., Schlegel, A., Imperial, J. S., Watkins, M., Bandyopadhyay, P. K., Yandell, M., Li, Q., Purcell, A. W., Norton, R. S., Ellgaard, Lars & Olivera, B. M., 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1743-1748 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. 2014

    42. Combined proteomic and transcriptomic interrogation of the venom gland of Conus geographus uncovers novel components and functional compartmentalization

      Safavi, Helena, Hu, H., Gorasia, D. G., Bandyopadhyay, P. K., Veith, P. D., Young, N. D., Reynolds, E. C., Yandell, M., Olivera, B. M. & Purcell, A. W., 2014, In: Molecular and Cellular Proteomics. 13, 4, p. 938-53 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae

      Robinson, S. D., Safavi, Helena, McIntosh, L. D., Purcell, A. W., Norton, R. S. & Papenfuss, A. T., 2014, In: PLoS ONE. 9, 2, e87648.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Giftsnegle som medicinskabe

      Safavi, Helena, Andersen, K. M. & Ellgaard, Lars, 2014, In: Aktuel Naturvidenskab. 2014, 2, p. 12-16 5 p.

      Research output: Contribution to journal › Journal article › Research

    45. Published

      The Opisthorchis viverrini genome provides insights into life in the bile duct

      Young, N. D., Nagarajan, N., Lin, S. J., Korhonen, P. K., Jex, A. R., Hall, R. S., Safavi-Hemami, H., Kaewkong, W., Bertrand, D., Gao, S., Seet, Q., Wongkham, S., Teh, B. T., Wongkham, C., Intapan, P. M., Maleewong, W., Yang, X., Hu, M., Wang, Z., Hofmann, A. & 4 others, Sternberg, P. W., Tan, P., Wang, J. & Gasser, R. B., 2014, In: Nature Communications. 5, 11 p., 4378.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. 2013

    47. High molecular weight components of the injected venom of fish-hunting cone snails target the vascular system

      Safavi, Helena, Möller, C., Marí, F. & Purcell, A. W., 8 Oct 2013, In: Journal of Proteomics. 91, p. 97-105 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. 2012

    49. Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails

      Safavi, Helena, Gorasia, D. G., Steiner, A. M., Williamson, N. A., Karas, J. A., Gajewiak, J., Olivera, B. M., Bulaj, G. & Purcell, A. W., 5 Oct 2012, In: The Journal of Biological Chemistry. 287, 41, p. 34288-303 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. 2011

    51. Specialisation of the venom gland proteome in predatory cone snails reveals functional diversification of the conotoxin biosynthetic pathway

      Safavi, Helena, Siero, W. A., Gorasia, D. G., Young, N. D., Macmillan, D., Williamson, N. A. & Purcell, A. W., 2 Sep 2011, In: Journal of Proteome Research. 10, 9, p. 3904-19 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function?

      Safavi, Helena, Siero, W. A., Kuang, Z., Williamson, N. A., Karas, J. A., Page, L. R., MacMillan, D., Callaghan, B., Kompella, S. N., Adams, D. J., Norton, R. S. & Purcell, A. W., 24 Jun 2011, In: The Journal of Biological Chemistry. 286, 25, p. 22546-57 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. 2010

    54. Proteomic interrogation of venom delivery in marine cone snails: novel insights into the role of the venom bulb

      Safavi, Helena, Young, N. D., Williamson, N. A. & Purcell, A. W., 5 Nov 2010, In: Journal of Proteome Research. 9, 11, p. 5610-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Characterisation of nitric oxide synthase in three cnidarian-dinoflagellate symbioses

      Safavi, Helena, Young, N. D., Doyle, J., Llewellyn, L. & Klueter, A., 28 Apr 2010, In: PLoS ONE. 5, 4, p. e10379

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins

      Safavi, Helena, Bulaj, G., Olivera, B. M., Williamson, N. A. & Purcell, A. W., 23 Apr 2010, In: The Journal of Biological Chemistry. 285, 17, p. 12735-46 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    ID: 45133101