Helena Safavi
Associate Professor, Guest Researcher
- 2023
- Published
A toxin-based approach to neuropeptide and peptide hormone discovery
Koch, Thomas Lund, Torres, Joshua, Baskin, R. P., Salcedo, P. F., Chase, K., Olivera, B. M. & Safavi, Helena, 2023, In: Frontiers in Molecular Neuroscience. 16, 14 p., 1176662.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Integrating Venom Peptide Libraries Into a Phylogenetic and Broader Biological Framework
Chase, K., Watkins, M., Safavi, Helena & Olivera, B. M., 2022, In: Frontiers in Molecular Biosciences. 9, 16 p., 784419.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Symmetric and asymmetric receptor conformation continuum induced by a new insulin
Xiong, X., Blakely, A., Kim, J. H., Menting, J. G., Schäfer, I. B., Schubert, H. L., Agrawal, R., Gutmann, T., Delaine, C., Zhang, Y. W., Artik, G. O., Merriman, A., Eckert, D., Lawrence, M. C., Coskun, Ü., Fisher, S. J., Forbes, B. E., Safavi, Helena, Hill, C. P. & Chou, D. H. C., 2022, In: Nature Chemical Biology. 18, 5, p. 511-519Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unconventional insulins from predators and pathogens
Laugesen, Sophie Heiden, Chou, D. H. C. & Safavi, Helena, 2022, In: Nature Chemical Biology. 18, 7, p. 688-697Research output: Contribution to journal › Review › Research › peer-review
- 2021
- Published
DisCoTune: versatile auxiliary plasmids for the production of disulphide-containing proteins and peptides in the E. coli T7 system
Bertelsen, A. B., Hackney, Celeste Menuet, Bayer, C. N., Kjelgaard, L. D., Rennig, M., Christensen, B., Sørensen, E. S., Safavi, Helena, Wulff, T., Ellgaard, Lars & Nørholm, M. H. H., 2021, In: Microbial Biotechnology. 14, 6, p. 2566-2580 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
A structurally minimized yet fully active insulin based on cone-snail venom insulin principles
Xiong, X., Menting, J. G., Disotuar, M. M., Smith, N. A., Delaine, C. A., Ghabash, G., Agrawal, R., Wang, X., He, X., Fisher, S. J., MacRaild, C. A., Norton, R. S., Gajewiak, J., Forbes, B. E., Smith, B. J., Safavi, Helena, Olivera, B., Lawrence, M. C. & Chou, D. H. C., 2020, In: Nature Structural and Molecular Biology. 27, p. 615-624Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research
Bjørn-Yoshimoto, Walden, Ramiro, Iris Bea L. , Yandell, M., McIntosh, J. M., Olivera, B. M., Ellgaard, Lars & Safavi, Helena, 2020, In: Biomedicines. 8, 8, 22 p., 235.Research output: Contribution to journal › Review › Research › peer-review
- Published
Transcriptomic Profiling Reveals Extraordinary Diversity of Venom Peptides in Unexplored Predatory Gastropods of the Genus Clavus
Lu, A., Watkins, M., Li, Q., Robinson, S. D., Concepcion, G. P., Yandell, M., Weng, Z., Olivera, B. M., Safavi, Helena & Fedosov, A. E., 2020, In: Genome Biology and Evolution. 12, 5, p. 684-700 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor
Ahorukomeye, P., Disotuar, M. M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S. D., Flórez Salcedo, P., Smith, N. A., Smith, B. J., Schlegel, A., Forbes, B. E., Olivera, B., Hung-Chieh Chou, D. & Safavi, Helena, 2019, In: eLife. 8, 28 p., e41574.Research output: Contribution to journal › Journal article › Research › peer-review
Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways
Safavi, Helena, Brogan, S. E. & Olivera, B. M., 2019, In: Journal of Proteomics. 190, p. 12-20 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework
Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi, Helena, Teilum, Kaare & Ellgaard, Lars, 2019, In: The Journal of Biological Chemistry. 294, 22, p. 8745-8759Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
Conopeptides promote itch through human itch receptor hMgprX1
Espino, S. S., Robinson, S. D., Safavi, Helena, Gajewiak, J., Yang, W., Olivera, B. M. & Liu, Q., 2018, In: Toxicon. 154, p. 28-34 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Discovery of Novel Conotoxin Candidates Using Machine Learning
Li, Q., Watkins, M., Robinson, S. D., Safavi, Helena & Yandell, M., 2018, In: Toxins. 10, 12, 503.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins
O'Brien, H., Kanemura, S., Okumura, M., Baskin, R. P., Bandyopadhyay, P. K., Olivera, B. M., Ellgaard, Lars, Inaba, K. & Safavi, Helena, 2018, In: International Journal of Molecular Sciences . 19, 11, 15 p., 3418.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evolutionary Adaptations to Cysteine-rich Peptide Folding
Safavi, Helena, Foged, M. M. & Ellgaard, Lars, 2018, Oxidative Folding of Proteins: Basic Principles, Cellular Regulation and Engineering . Feige, M. J. (ed.). Royal Society of Chemistry, p. 99-128 30 p. (Chemical Biology, Vol. 9).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2017
- Published
Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study
Olivera, B. M., Raghuraman, S., Schmidt, E. W. & Safavi, Helena, Oct 2017, In: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 203, 9, p. 717-735 19 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Hormone-like peptides in the venoms of marine cone snails
Robinson, S. D., Li, Q., Bandyopadhyay, P. K., Gajewiak, J., Yandell, M., Papenfuss, A. T., Purcell, A. W., Norton, R. S. & Safavi, Helena, 1 Apr 2017, In: General and Comparative Endocrinology. 244, p. 11-18 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus
Li, Q., Barghi, N., Lu, A., Fedosov, A. E., Bandyopadhyay, P. K., Lluisma, A. O., Concepcion, G. P., Yandell, M., Olivera, B. M. & Safavi, Helena, 2017, In: Genome Biology and Evolution. 9, 9, p. 2211-2225 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Isolation and characterization of Conohyal-P1, a hyaluronidase from the injected venom of Conus purpurascens
Möller, C., Clark, E., Safavi, Helena, DeCaprio, A. & Marí, F., 2017, In: Journal of Proteomics. 164, p. 73-84 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea
Robinson, S. D., Li, Q., Lu, A., Bandyopadhyay, P. K., Yandell, M., Olivera, B. M. & Safavi, Helena, 2017, In: Marine Drugs. 15, 5, 145.Research output: Contribution to journal › Journal article › Research › peer-review
Venom peptides as pharmacological tools and therapeutics for diabetes
Robinson, S. D. & Safavi, Helena, 2017, In: Neuropharmacology. 127, p. 79-86 8 p.Research output: Contribution to journal › Review › Research › peer-review
- 2016
A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold
Robinson, S. D., Chhabra, S., Belgi, A., Chittoor, B., Safavi, Helena, Robinson, A. J., Papenfuss, A. T., Purcell, A. W. & Norton, R. S., 2016, In: Structure. 24, 2, p. 293-299 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin
Menting, J. G., Gajewiak, J., MacRaild, C. A., Chou, D. H., Disotuar, M. M., Smith, N. A., Miller, C., Erchegyi, J., Rivier, J. E., Olivera, B. M., Forbes, B. E., Smith, B. J., Norton, R. S., Safavi, Helena & Lawrence, M. C., 2016, In: Nature Structural and Molecular Biology. 23, 10, p. 916-920 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
A prominent role of PDIA6 in processing of misfolded proinsulin
Gorasia, D. G., Dudek, N. L., Safavi, Helena, Perez, R. A., Schittenhelm, R. B., Saunders, P. M., Wee, S., Mangum, J. E., Hubbard, M. J. & Purcell, A. W., 2016, In: B B A - Reviews on Cancer. 1864, 6, p. 715-723 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin as a weapon
Robinson, S. D. & Safavi, Helena, 2016, In: Toxicon. 123, p. 56-61 6 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides
Safavi, Helena, Li, Q., Jackson, R. L., Song, A. S., Boomsma, Wouter, Bandyopadhyay, P. K., Gruber, C. W., Purcell, A. W., Yandell, M., Olivera, B. M. & Ellgaard, Lars, 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. 3227-3232 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Venom insulins of cone snails diversify rapidly and track prey taxa
Safavi, Helena, Lu, A., Li, Q., Fedosov, A. E., Biggs, J., Corneli, P. S., Seger, J., Yandell, M. & Olivera, B. M., 2016, In: Molecular Biology and Evolution. 33, 11, p. 2924-2934 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom
Robinson, S. D., Safavi, Helena, Raghuraman, S., Imperial, J. S., Papenfuss, A. T., Teichert, R. W., Purcell, A. W., Olivera, B. M. & Norton, R. S., 2015, In: Journal of Proteomics. 114, p. 38-47 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus
Aman, J. W., Imperial, J. S., Ueberheide, B., Zhang, M., Aguilar, M., Taylor, D., Watkins, M., Yoshikami, D., Showers-Corneli, P., Safavi, Helena, Biggs, J., Teichert, R. W. & Olivera, B. M., 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 16, p. 5087-5092 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pancreatic beta cells are highly susceptible to oxidative and ER stresses during the development of diabetes
Gorasia, D. G., Dudek, N. L., Veith, P. D., Shankar, R., Safavi, Helena, Williamson, N. A., Reynolds, E. C., Hubbard, M. J. & Purcell, A. W., 2015, In: Journal of Proteome Research. 14, 2, p. 688-99 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Specialized insulin is used for chemical warfare by fish-hunting cone snails
Safavi, Helena, Gajewiak, J., Karanth, S., Robinson, S. D., Ueberheide, B., Douglass, A. D., Schlegel, A., Imperial, J. S., Watkins, M., Bandyopadhyay, P. K., Yandell, M., Li, Q., Purcell, A. W., Norton, R. S., Ellgaard, Lars & Olivera, B. M., 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1743-1748 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
Combined proteomic and transcriptomic interrogation of the venom gland of Conus geographus uncovers novel components and functional compartmentalization
Safavi, Helena, Hu, H., Gorasia, D. G., Bandyopadhyay, P. K., Veith, P. D., Young, N. D., Reynolds, E. C., Yandell, M., Olivera, B. M. & Purcell, A. W., 2014, In: Molecular and Cellular Proteomics. 13, 4, p. 938-53 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae
Robinson, S. D., Safavi, Helena, McIntosh, L. D., Purcell, A. W., Norton, R. S. & Papenfuss, A. T., 2014, In: PLoS ONE. 9, 2, e87648.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Giftsnegle som medicinskabe
Safavi, Helena, Andersen, K. M. & Ellgaard, Lars, 2014, In: Aktuel Naturvidenskab. 2014, 2, p. 12-16 5 p.Research output: Contribution to journal › Journal article › Research
- Published
The Opisthorchis viverrini genome provides insights into life in the bile duct
Young, N. D., Nagarajan, N., Lin, S. J., Korhonen, P. K., Jex, A. R., Hall, R. S., Safavi-Hemami, H., Kaewkong, W., Bertrand, D., Gao, S., Seet, Q., Wongkham, S., Teh, B. T., Wongkham, C., Intapan, P. M., Maleewong, W., Yang, X., Hu, M., Wang, Z., Hofmann, A. & 4 others, , 2014, In: Nature Communications. 5, 11 p., 4378.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
High molecular weight components of the injected venom of fish-hunting cone snails target the vascular system
Safavi, Helena, Möller, C., Marí, F. & Purcell, A. W., 8 Oct 2013, In: Journal of Proteomics. 91, p. 97-105 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails
Safavi, Helena, Gorasia, D. G., Steiner, A. M., Williamson, N. A., Karas, J. A., Gajewiak, J., Olivera, B. M., Bulaj, G. & Purcell, A. W., 5 Oct 2012, In: The Journal of Biological Chemistry. 287, 41, p. 34288-303 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
Specialisation of the venom gland proteome in predatory cone snails reveals functional diversification of the conotoxin biosynthetic pathway
Safavi, Helena, Siero, W. A., Gorasia, D. G., Young, N. D., Macmillan, D., Williamson, N. A. & Purcell, A. W., 2 Sep 2011, In: Journal of Proteome Research. 10, 9, p. 3904-19 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function?
Safavi, Helena, Siero, W. A., Kuang, Z., Williamson, N. A., Karas, J. A., Page, L. R., MacMillan, D., Callaghan, B., Kompella, S. N., Adams, D. J., Norton, R. S. & Purcell, A. W., 24 Jun 2011, In: The Journal of Biological Chemistry. 286, 25, p. 22546-57 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
Proteomic interrogation of venom delivery in marine cone snails: novel insights into the role of the venom bulb
Safavi, Helena, Young, N. D., Williamson, N. A. & Purcell, A. W., 5 Nov 2010, In: Journal of Proteome Research. 9, 11, p. 5610-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Characterisation of nitric oxide synthase in three cnidarian-dinoflagellate symbioses
Safavi, Helena, Young, N. D., Doyle, J., Llewellyn, L. & Klueter, A., 28 Apr 2010, In: PLoS ONE. 5, 4, p. e10379Research output: Contribution to journal › Journal article › Research › peer-review
Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins
Safavi, Helena, Bulaj, G., Olivera, B. M., Williamson, N. A. & Purcell, A. W., 23 Apr 2010, In: The Journal of Biological Chemistry. 285, 17, p. 12735-46 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 45133101
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The Opisthorchis viverrini genome provides insights into life in the bile duct
Research output: Contribution to journal › Journal article › Research › peer-review
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216
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Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways
Research output: Contribution to journal › Journal article › Research › peer-review
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143
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Venom insulins of cone snails diversify rapidly and track prey taxa
Research output: Contribution to journal › Journal article › Research › peer-review
Published